Why do symptoms linger in #Crohnsdisease in remission❓ Recent findings from @IBDimmunology, @umfoodoc & colleagues found clues: ✅ Patients with quiescent Crohn's and persistent symptoms were enriched in sulfur-containing amino acid pathways ✅ Downstream mitochondrial function was also perturbed ✅ Patients with quiescent Crohn's and persistent symptoms shared similar microbial diversity, community structure, and metabolites with active Crohn's ✅ A dietary pattern that reduces the growth of sulfur-metabolizing gut microorganisms has shown potential benefits in adults with mild–moderately active ulcerative colitis by @Alice_APD et al. and might be considered also in some patients with Crohn's in remission: 🔸 Prioritize intake of fruits, vegetables and fiber (> 30g fiber/day) 🔸 Gluten is allowed 🔸 Moderate animal protein intake (1 g/kg) 🔸 ⬇️ meat intake 🔸 ⬇️ additives 💡 Despite normalization of inflammation, gut microbiome structure and functions can be altered in patients with Crohn's with persistent symptoms 👉 diet can help by preventing the bloom of microbes that feed on dietary sulfur 📚 Read the full research in @IBDJournals : academic.oup.com/ibdjournal/…