Good advice. It’s like going though all the questions one did wrong after an exam
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yeah, in ChatGPT either nonexistent DOIs are provided or DOIs are completely disconnected from the content. like you ask show me a citation on planetary physics and it shows you a DOI that refers to medicine. same goes for PMID numbers
This time some DOIs were real, resolving to the correct journal, year and volume, but on a completely different topic.
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how to submit a grant on time
In keeping with New Year's aerial traditions.
The flight that takes off in 2023 and lands in 2022.
Via: @flightradar24
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just stop - get your facts straight about the infrastructure of NIH. Unfounded statements create hate.
Fauci is at the NIAID which has its own ethics office:
niaid.nih.gov/about/ethics-c…
Grady is at the Bioethics department which does training, and consulting and is part of NIH CC.
Almost no one seems to realize that the head of bioethics at NIH – the person who is supposed to make sure that Fauci behaves ethically – is his wife 🧐
en.m.wikipedia.org/wiki/Chri…
Readers added context they thought people might want to know
This is a common misunderstanding of the purpose of the NIH bioethics department. It is the department of the agency that conducts research into bioethical issues. It is not an internal oversight department for monitoring or policing ethics of NIH employees, and never has been.
bioethics.nih.gov/about/index.sh…
what an excellent overview of "how to interpret VAFs of mutations", or how variants with low VAF can be germline, and variants with VAF ~50% or higher can be somatic. Skin biopsy would be great in many cases but a systematic step-by-step analysis can solve the case as shown here
I love cases that make me think.. Never a dull day at #hemepathMDA
Tune in: a #hemepath #MDSSM case for your learning pleasure.. Enjoy!
This is the bone marrow of an elderly woman (>65 yr) with marked pancytopenia and progressive transfusion dependency. 🧵 1/
outstanding summary. Know your spleen! Also extremely helpful during workup of pancytopenia patient (leukemic process - spleen can be big, aplastic anemia/MDS - no big spleen).
Patients with myelofibrosis (MF) often present with a large spleen.
👉significant burden for patients
👉challenge for clinical management
👉esp for many colleagues in BMT, which is still the only curative treatment for MF
So, let's talk about the spleen 🧵
#MedTwitter #mpnsm
This is a great group and a great place to be - highly recommended for top notch science
We are announcing a full professorship (W3) in Experimental Hematology here at @UniklinikAachen @RWTH . The focus will be on hematopoietic stem cell disorders. Those who are interested, please contact myself, @rschneiderlab or @KoschmiederS
Congrats to @MassimoFederic0 and the Ukrainian colleagues on doing incredible work despite the horrendous situation in #Ukraine like with the #SAFERUkraine network for kids with cancer and blood diseases, international collaborations are key. @ASH_hematology
Thank you @NicoGagelmann for a quick tutorial on what is adult MPN and how to cure it (allo HSCT is the answer but that is obvious when you know his tweets)
Reduced intensity conditioning is the norm for HSCT in telomeropathies. Androgens can be used as a bridge to transplant but we still don't know how they work. Great talk by @SharonSavageMD on therapy standards in these rare devastating syndromes:
Lets get back to basics of hematology at #ASH22: what is classic dyskeratosis congenita? @SharonSavageMD
Critical to intercept the momentum in Fanconi Anemia. Once patients develop MDS/AML, it is difficult to treat. However, FLAG followed by sequential HSCT has OS of 50%:
Haplo HSCT in Fanconi anemia (Carlo Dufour at #ASH22: two platforms gain advantage and can be successfully used:
alphabeta CD19 depleted:
Carlo Dufour at #ASH2022 @ASH_hematology - did you know that Moya-Moya syndrome can occur in Fanconi Anemia? Also pay special attention to oral cavity in Fanconi Anemia.
Inhibition of CXCR4 rescues phenotype in WHIM syndrome - international trial ongoing - great potential for new drugs developed for old concepts (Jean Doneadieu at #ASH22).
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Dapaglifozin (SGLT2 inhibitor) for treatment of neutropenia due to Glycogen storage disease type Ib and G6PC3 congenital neutropenia - it works! as presented by Jean Donadieau at #ASH22 Novel and exciting.
What is new in classical bone marrow failure syndromes (focus on therapies)? Come see the educational session in Room 260 at #ASH22 2:45pm
@SharonSavageMD Jean Donadieu and Carlo Dufour give their expert insights on how to treat inherited BMF
