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Spirochrome

@spirochrome

Our main focus is to offer innovative tools for live cell fluorescence imaging to the scientific community.

 Switzerland
spirochrome.com/
Joined August 2018
  • Tweets1K
  • Following974
  • Followers2.7K
You can't image what you can't see. Spirochrome makes it visible. 📄 4,000+ published articles 🌍 Hundreds of research groups worldwide 📰 High-impact journals Fluorescent probes that push the boundaries of live-cell imaging. → spirochrome.com/
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FYI except for the mtDNA in the 4th clip of the video, all labels are Spirochrome live cell probes!
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Spirochrome retweeted
Spirochrome (@spirochrome) profile picture
Spirochrome@spirochromeOct 29
You can't image what you can't see. Spirochrome makes it visible. 📄 4,000+ published articles 🌍 Hundreds of research groups worldwide 📰 High-impact journals Fluorescent probes that push the boundaries of live-cell imaging. → spirochrome.com/
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Spirochrome is on Bluesky! Don't forget to give us a follow when you make it there, we'll follow you back! 🦋🦋🦋
Image from Spirochrome (@spirochrome)
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Spirochrome probes: the Standard for live-cell imaging. 📊 1700+ publications cite SiR-actin, 📊 1300+ cite SiR-tubulin, 📊 1200+ cite SiR-DNA Trusted by thousands of labs worldwide. Join the community → spirochrome.com/products/?_c… #LiveCellImaging #Microscopy #Fluorescence
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Spirochrome retweeted
Spirochrome (@spirochrome) profile picture
Spirochrome@spirochromeJun 1
And it's not all: For an exceptional new product, an exceptional new casing! We designed new boxes that we will gradually deploy to replace our old metal boxes. 4 designs will be randomly used for each product!
Image from Spirochrome (@spirochrome)
Image from Spirochrome (@spirochrome)
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Today is the Day, CenSpark650 is available! Time to get those centrioles and cilia shining under the 🔬objective! spirochrome.com/product/cens… video: 20h imaging of primary cilium formation in a single RPE-1 cell stained with CenSpark650. movie credits: Cédric Pourroy
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And it's not all: For an exceptional new product, an exceptional new casing! We designed new boxes that we will gradually deploy to replace our old metal boxes. 4 designs will be randomly used for each product!
Image from Spirochrome (@spirochrome)
Image from Spirochrome (@spirochrome)
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📢On June 1st, we will be launching CenSpark650, the very first selective fluorescent probe for imaging centrioles and cilia in live cells.🔬 No transfection, zero genetic manipulation. Just Add & Image 1 hour later. Learn more: spirochrome.com/12-may-2026/ #Bioimaging
Image from Spirochrome (@spirochrome)
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We strongly recommend reading the article by Cedric Pourroy et al. to get to know everything CenSpark650 can do and beyond: nature.com/articles/s41589-0…
Development of the fluorescent probe CenSpark for labeling centrioles and cilia

Development of the fluorescent probe CenSpark for labeling centrioles and cilia

Nature Chemical Biology - CenSpark is a dual-ligand fluorescent probe binding simultaneously inner and outer microtubule sites, a configuration unique to doublet and triplet microtubules, enabling...

nature.com
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Casually posting this one for no particular reason! #MayTheFourth
Image from Spirochrome (@spirochrome)
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Spirochrome retweeted
Spirochrome (@spirochrome) profile picture
Spirochrome@spirochromeMay 1
Overly proud that Katie Holden's image won Evident Microscopy's 6th Annual Image of the Year "Global Winner" award🏆 The image shows live iPSC-derived neurospheres. DNA (magenta) & MT (blue) were stained with our probes SiR-tubulin & SPY555-DNA probes evidentscientific.com/en/lan…
Image from Spirochrome (@spirochrome)
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Overly proud that Katie Holden's image won Evident Microscopy's 6th Annual Image of the Year "Global Winner" award🏆 The image shows live iPSC-derived neurospheres. DNA (magenta) & MT (blue) were stained with our probes SiR-tubulin & SPY555-DNA probes evidentscientific.com/en/lan…
Image from Spirochrome (@spirochrome)
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If you want to know more about IPSC-derived neurospheres, we strongly advise to read Katie Holden's research article which introduces this technology: doi.org/10.1016/j.bbi.2023.1… Congrats Katie!
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Spirochrome retweeted
Spirochrome (@spirochrome) profile picture
Spirochrome@spirochromeApr 23
Mesmerizing light sheet imaging of neutrophils swarming at a yeast target! The neutrophils were labeled with SPY650-DNA (yellow) and a calcium dye (blue). This movie is part of the recent manuscript by Evelyn Strickland that we highly recommend reading! biorxiv.org/content/10.64898…
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CenSpark is a dual-ligand fluorescent probe simultaneously binding inner and outer microtubule sites – a configuration unique to doublet and triplet microtubules, enabling selective live imaging of centrioles and cilia across species nature.com/articles/s41589-0…
Development of the fluorescent probe CenSpark for labeling centrioles and cilia

Development of the fluorescent probe CenSpark for labeling centrioles and cilia

Nature Chemical Biology - CenSpark is a dual-ligand fluorescent probe binding simultaneously inner and outer microtubule sites, a configuration unique to doublet and triplet microtubules, enabling...

nature.com
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Mesmerizing light sheet imaging of neutrophils swarming at a yeast target! The neutrophils were labeled with SPY650-DNA (yellow) and a calcium dye (blue). This movie is part of the recent manuscript by Evelyn Strickland that we highly recommend reading! biorxiv.org/content/10.64898…
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Spirochrome retweeted
CSR Biotech (@CSRBiotech) profile picture
CSR Biotech@CSRBiotechApr 7
Such a great example of what MI-SIM can reveal! #livecell #MISIM
Spirochrome (@spirochrome) profile pictureSpirochrome@spirochromeApr 1
Beware the SPY488-FastAct rollercoaster! We teamed up with @CSRBiotech and their incredible MI-SIM microscope to drive you through the intricate actin network of live COS7 cells stained with SPY488-FastAct. Find out more about SPY488-FastAct: spirochrome.com/product/spy4…
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Beware the SPY488-FastAct rollercoaster! We teamed up with @CSRBiotech and their incredible MI-SIM microscope to drive you through the intricate actin network of live COS7 cells stained with SPY488-FastAct. Find out more about SPY488-FastAct: spirochrome.com/product/spy4…
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🙏 @christlet for the cool "Animated Zooming" & "Animated panning" ImageJ plugins used here! 😎
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