A clinician scientist at LTRI @sinaihealth studying GLP-1, diabetes, obesity and the gut endocrine system Proud 🇨🇦Not going anywhere Am 🇮🇱Chai
Toronto
Joined May 2011
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How do GLP-1 meds improve liver health through #weightloss independent mechanisms? Here @ChusaGzlzRellan & colleagues identify Liver Sinusoidal Endothelial Cells as direct targets of semaglutide, linking LSECs to reduction of #inflammation #Fibrosis #MASH cell.com/cell-metabolism/abs…
Retatrutide and the improvement of obstructive sleep apnea nejm.org/doi/full/10.1056/NE…
Daniel J Drucker retweeted
GLP-1 peptides protect the gut from immune injury.
Essential role of endogenous GLP-1 family peptides to reduce inflammation and restore mucosal integrity in the experimental model @DanielJDrucker @CellRepMed
cell.com/cell-reports-medici…
Will GLP-1 medicines be useful in the clinic for substance use disorders? We will soon find out @marilenharo nature.com/articles/d41586-0…
This Friday 8 am @SinaiHealth @uoftmedicine in Toronto, the 2026 Burrow Lecture, 8 am, Professor @cevansmo #Diabetes #islets
Over 6 weeks in people with MASLD inhibition of fructose metabolism has beneficial metabolic effects that extend beyond the organs that metabolize fructose @NatMetabolism
nature.com/articles/s42255-0…
Here the authors propose that a gut microbial aldehyde-alcohol dehydrogenase, AdhE, converts metformin to pharmacologically inactive products, lowering intestinal and systemic drug exposure cell.com/cell-metabolism/ful… @Cell_Metabolism
New P3 data for the oral small-molecule GLP-1 receptor agonist safiglipron in early type 2 diabetes in China @NatureMedicine
nature.com/articles/s41591-0…
Genetic variation and type 2 #diabetes New perspectives @MolMetab sciencedirect.com/science/ar… @DiabetologiaJnl
Daniel J Drucker retweeted
SCOOP: Top researchers at Columbia, Stanford, and others thought they were elected to elite scientific societies alongside Nobel laureates. The catch? The organizations are a sham.
I spent the last month investigating a massive academic scam, for @Nature
nature.com/articles/d41586-0…
A childhood window into genetic variation linked to childhood adiposity @NatureGenet nature.com/articles/s41588-0…
Cohort studies across the lifespan for type 2 #diabetes Progress, clinical implementation and future directions @DiabetologiaJnl link.springer.com/article/10…
Here the authors identify the glucagon-PKA-PDE2A-NCLX signaling axis as a key metabolic rheostat integrating mitochondrial calcium dynamics with lipid homeostasis, providing a promising therapeutic target for MASLD @MolMetab sciencedirect.com/science/ar…
The weight loss proteome in mice nature.com/articles/s42255-0… @NatMetabolism
In an open label study for up to 26 weeks, dulaglutide was associated with greater improvements in glycaemic control and variability compared with insulin among adolescents with transfusion-dependent β-thalassaemia (TDT)-induced diabetes @DiabetologiaJnl link.springer.com/article/10…
From TMAO to DNICs the expanding concepts linking microbiota metabolism to cardiovascular and metabolic pathways. Modulating DNIC formation by the gut microbiota could be a strategy to support cardiometabolic health @CellCellPress cell.com/cell/fulltext/S0092…
New studies in Drosophila and mice redefine the intestinal muscle as a responder to specific signals that adjust adult organ (intestine) features and sustain reproductive demands.
cell.com/cell/fulltext/S0092…
A framework identifying ten priorities in #T2D prevention, toward context-specific, actionable interventions capable of altering the natural history of disease early in the life course and restoring metabolic health. nature.com/articles/s41591-0…
The decades long quest for reprogramming islet cell phenotypes #diabetes continues here using a metabolic pathway approach nature.com/articles/s41589-0…
Daniel J Drucker retweeted
The GLP-1 drugs have evidence for beneficial impact— heart, kidney, liver, joints, immune system, and brain—that are independent of weight loss
@Cell_Metabolism @DanielJDrucker
cell.com/cell-metabolism/abs…
How does GLP-1 work? Gustav Hållén the producer of Zero Order has figured it out. Have a listen
youtube.com/watch?v=VCIWc2TX…