physician-scientist, author of SUPER AGERS https://xitter.gq/t.co/ZEdooyyJpP and Ground Truths: https://xitter.gq/t.co/YhatcBT0hA
La Jolla, CA
Joined November 2009
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A new cover for SUPER AGERS after making the NYT bestseller list. Thanks to you for making it the #1 ranked new non-fiction book on Amazon.
amazon.com/gp/new-releases/b…
Will life science and medicine go through the "bitter lesson" (AI innovation, brute force power) as we've recently seen with mathematics?
53%Yes
28%No
20%Maybe
384 votes • 22 hoursIn people with a new diagnosis of coronary artery disease, no prior statin Rx (N=104), getting the LDL down to ~40 vs 70 mg/dL (via the 2 regimens, randomized, shown below) led to 20% more regression of atherosclerotic plaque in just 18 months @JAMACardio The lower the LDL, the more regression
jamanetwork.com/journals/jam…
Discovery of 48 new, common genomic loci (a ~60% jump) associated with Alzheimer's disease. A high proportion of the new loci are tagged to brain immune cell (microglia) function @Nature
nature.com/articles/s41586-0…
Hallf of people with obesity are considered metabolically healthy (MHO), from a new review on obesity @NatureMedicine nature.com/articles/s41591-0…
Seeing a potential benefit of high blood sugar is unusual, to say the least.
High blood glucose improved T cell (CD8+) function to take on cancer, in experimental models and in vitro with human cells, with a mechanistic explanation
academic.oup.com/jimmunol/ar…
Caloric restriction (CR), in many species, extends lifespan. In a new study, CR reduced the accumulation of somatic mutations, but that was not enough to account for change in lifespan. Work in the experimental model.
cell.com/cell/abstract/S0092…
cell.com/cell/abstract/S0092…
Eric Topol retweeted
As #ArtificialIntelligence becomes increasingly embedded in clinical care, many systems rely on a "human-in-the-loop" model in which clinicians review and approve AI-generated recommendations. A new commentary suggests that this approach may be less effective than intended when clinicians face high workloads and limited time to review AI-generated outputs. The authors call for stronger oversight, testing, and monitoring of these technologies as their role in health care continues to expand. bit.ly/47O9R4l @EricTopol @pranavrajpurkar
Current status of the jagged frontier of AI in medicine
Interview @AnnalsofIM
acpjournals.org/doi/10.7326/…
Th distinct features of colon cancer in the young at single-nucleus resolution, both unfavorable and potentially helpful for understanding why this is on the rise @NatureMedicine
nature.com/articles/s41591-0…
When a chatbot for health advice led to tragedy
Front page NYT today @teddyrosenbluth
gift link
nytimes.com/2026/10/27/well/…
video nytimes.com/video/well/10000…
Agentic AI detected adverse events of cancer immunotherapy, which are frequently missed, in real world medicine
nature.com/articles/s43018-0…
Eric Topol retweeted
We're unable to measure our immune system status in the clinic. But that is about to change.
Our @nature piece today, w/ @HugoAerts @nbirkbak @TsangLab
nature.com/articles/d41586-0…
Just published @TheLancet
Declaring climate change as a global health emergency
And what needs to be done about it
thelancet.com/journals/lance…
From today's "Is There Anything BPC-157 Can't Cure?" @TheAtlantic by @tebartl
A rodent panacea
theatlantic.com/magazine/202…
We're unable to measure our immune system status in the clinic. But that is about to change.
Our @nature piece today, w/ @HugoAerts @nbirkbak @TsangLab
nature.com/articles/d41586-0…
The science of aging with one of its top researchers, Vadim Gladyshev @gladyshev_lab, and optimism for slowing biological aging
with transcript, open-access, w/ links to his many recent papers
erictopol.substack.com/p/vad…
