Systems, scaling and architecture for general biological intelligence
San Francisco & Tokyo
Joined May 2025
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1/ With Omnii Diagnostics, we asked whether a multimodal genome language model could help find cancers whose signals in blood are too faint for current classifiers.
We adapted Omnii-1 to a biomarker never seen in pretraining. In a test cohort, Omnii's features improved early-stage cancer detection
7/ One question is whether Omnii-1 leaned on risk proxies like age or sex.
If so, gains would likely cluster in some groups. Instead, at a fixed threshold, its features raised early-stage sensitivity for women, men, and every age group tested.
8/ With Omnii Diagnostics, we showed that pretraining across biological modalities transfers to a new biomarker, extending the range of Omnii applications.
Further studies are needed to confirm detection gains in larger screening populations.
We continue to work with our partners to build the next generation of diagnostics with Omnii.
radicalnumerics.ai/blog/omni…
1/10 Introducing Omnii Genome, one of eight Advances built on Omnii-1.
A single generalist model now outperforms leading specialized models (AlphaGenome) in linking genetic changes to gene activity and mapping regulatory interactions.
These capabilities help make sense of the 98% of the human genome that doesn’t code for proteins
How Omnii-1 works:
10/ Omnii Genome brings us closer to understanding how changes in DNA affect biological function, and eventually designing changes that produce desired effects.
Explore the results:
radicalnumerics.ai/blog/omni…
Join us: radicalnumerics.ai/join-us
More thoughts from our own @m_m_carter xitter.gq/m_m_carter/status/2113…
Launching Omnii-1, our most powerful genome language model yet.
