@ASThatte2

UT Austin ‘21 to Ph.D. Student at UPenn • @MJMitchell_Lab @NSF Graduate Research Fellow • Lipid Nanoparticles for Immune Engineering • BlueSky: ASThatte

Joined October 2021
  • Tweets88
  • Following246
  • Followers176
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Super excited to share a major part of my dissertation work, now out in Advanced Materials!
Mike Mitchell@MJMitchell_LabAug 6
Check out our latest in Advanced Materials led by recent @MJMitchell_Lab PhD @ASThatte2 in collaboration w @JilianMelamed @WeissmanLab on a steroid LNP platform for mRNA delivery while mitigating inflammation for treating autoimmune disease! Open access: doi.org/10.1002/adma.74301
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Mike Mitchell@MJMitchell_LabJun 4
Excited to announce that @MJMitchell_Lab PhD student @ASThatte2's thesis defense titled “Engineering mRNA lipid nanoparticles to combat inflammatory and autoimmune disease” is tomorrow, June 5th at 2 PM ET! Location: Glandt Forum, @UPennSinghNano Zoom: upenn.zoom.us/j/95017690612
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Alex Hamilton@a_hmltnJan 29
Thrilled to share the final installment from my Ph.D. research @MJMitchell_Lab! Featuring high-throughput screening using molecular barcoding, a cancer vaccine model, and new tools to evaluate LNP protein corona formation! Read it in Advanced Materials: doi.org/10.1002/adma.2025143…

High‐Throughput In Vivo Screening Using Barcoded mRNA Identifies Lipid Nanoparticles With Extrahe...

A high-throughput in vivo mRNA LNP screening platform is developed and employed to screen a large library of 122 mRNA LNPs in vivo for delivery to immune, stromal, and parenchymal cells, identifying...

advanced.onlinelibrary.wiley.com
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Had so much fun writing this Focus Article on next-gen CAR T cell engineering using lipid nanoparticles!
Mike Mitchell@MJMitchell_Lab21 Oct 2025
Check out our latest in Nanoscale Horizons co-led by @MJMitchell_Lab Postdocs and PhD students Melgious Ang, Ann Metzloff, and @ASThatte2 on lipid nanoparticles for engineering next generation CAR T cell immunotherapy! pubs.rsc.org/en/content/arti…

Lipid nanoparticles for engineering next generation CAR T cell immunotherapy

Lipid nanoparticles are a burgeoning technology which has vast potential to improve chimeric antigen receptor (CAR) T cell immunotherapy. This focused revi

pubs.rsc.org
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Thank you to #CRS2025 for the award! Huge thanks to @MJMitchell_Lab for all the support and @WeissmanLab @JilianMelamed for being the best collaborators!
Mike Mitchell@MJMitchell_Lab18 Jul 2025
Huge congrats to @MJMitchell_Lab PhD student @ASThatte2 for winning the @Merck best poster award at #CRS2025 for his work on mRNA LNP autoimmune therapies! @CRSScience
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We will also have two posters by @ASThatte2 on steroid lipid nanoparticles for mRNA autoimmune disease therapeutics and Melgious Ang on photoactivatable lipid nanoparticles! #CRS2025 @CRSScience
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Mitchell Lab is off to #CRS2025 to give 8 talks by @Junchao_online @_emilyhan_ @DongyoonKim5 @HannahGeisler_ @ShiQiangqiang @hannahyamagata @hannahsafford_ on mRNA vaccines, lipid nanoparticles, cancer immunotherapy, fetal and maternal health, CNS targeting and more! @CRSScience
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Breaking News: A baby with a rare disorder made medical history by receiving the first custom gene-editing treatment. The technique used has the potential to help people with thousands of other uncommon genetic diseases. nyti.ms/4j3xGs8

Baby Is Healed With World’s First Personalized Gene-Editing Treatment (Published 2025)

The technique used on a 9½-month-old boy with a rare condition has the potential to help people with thousands of other uncommon genetic diseases.

nytimes.com
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Check out our latest publication in @nanoletters led by @MJMitchell_Lab PhD student and lab softball Coach @hannahsafford_ where we explore tuning LNP elasticity using atomic force microscopy to enhance mRNA LNP delivery to the placenta! Link to article: pubs.acs.org/doi/full/10.102…
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Congrats to star undergrad, Ben Nachod for winning the William C. Hall Scholarship! Great job! 🎉@MJMitchell_Lab @PennEngineers @pennbioeng
SFBiomaterials@SFBiomaterials12 Feb 2025
We are thrilled to announce the Society's 2025 Award Recipients and celebrate their remarkable achievements in the field of biomaterials science. Join us in applauding the exceptional leaders who are shaping the future of biomaterials! Read more here - bit.ly/3CRnWSH
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Standing room only for @SwingleKelsey’s seminar on mRNA LNPs to treat pregnancy disorders at @Penn’s Center for Women’s Health hosted by @Marisa_S_B! What a special opportunity to see one of our own from @MJMitchell_Lab give their faculty interview seminar on campus! #proudPI
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Very excited to share our new work, now on @biorxivpreprint, on specificity of memory in human macrophages biorxiv.org/content/10.1101/… (1/8)

Innate Immune Memory is Stimulus Specific

Innate immune memory (also termed trained immunity) is defined in part by its ability to cross-protect against heterologous pathogens, and can be generated by many different stimuli, suggesting a...

biorxiv.org
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Thrilled to share our recent work out today in @Nature on an mRNA therapeutic to treat pre-eclampsia! This work has been a true passion project from my time @pennbioeng in @MJMitchell_Lab, and I’m excited to continue important research in women’s health! nature.com/articles/s41586-0…

Placenta-tropic VEGF mRNA lipid nanoparticles ameliorate murine pre-eclampsia

Nature - A platform for mRNA lipid nanoparticle delivery to the placenta to treat pre-eclampsia is shown to improve fetal and maternal health in mice and has potential clinical applications in...

nature.com
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Come check out a killer poster by @hannahyamagata on a new class of aromatic lipid nanoparticles that outperform industry standard mRNA vaccines this morning at 10am at #BMES2024! We also have two posters by @MJMitchell_Lab undergrads Ben Nachod and Sridatta Teerdhala!
Mike Mitchell@MJMitchell_Lab23 Oct 2024
Mitchell Lab is off to Baltimore to give 18 presentations at #BMES2024, including 10 talks on mRNA LNP technology for immunotherapy, vaccines, pregnancy, crossing the blood-brain barrier, and more! We are hiring Postdocs and PhD students, come chat with the team if interested!
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Enjoyed highlighting this comprehensive study in @NatChemEng linking biophysical cues to mechanisms of gene delivery!
Mike Mitchell@MJMitchell_Lab11 Sep 2024
Check out our latest in Nature Chemical Engineering @NatChemEng led by @MJMitchell_Lab PhD student @ASThatte2 and Postdoc @DongyoonKim5 on Hai-Quan Mao's work identifying fluid viscosity as a key biophysical parameter governing gene delivery! Free access: rdcu.be/dTD2b
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Emerging strategies for nanomedicine in autoimmunity by @ASThatte2 @MagBillingsley @JilianMelamed @WeissmanLab @MJMitchell_Lab Link: sciencedirect.com/science/ar…
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Thrilled to share our full special issue on drug delivery tech for autoimmunity therapies in @ADDReditors co-edited with @jdweaverBME @RyanMPearson @GormleyLab! Issue: sciencedirect.com/special-is… Editorial led by @ASThatte2: sciencedirect.com/science/ar… Amazing contributions including:
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Excited to contribute to this special issue highlighting drug delivery strategies for next-gen autoimmunity therapies!
Editors of Advanced Drug Delivery Reviews@ADDReditors20 Aug 2024
ADDR 50 days' free access: [Editorial] Drug Delivery Technologies for Autoimmunity Therapies. By Michael J. Mitchell & coworkers @pennbioeng @MJMitchell_Lab #DrugDelivery #AutoimmuneDisease kwnsfk27.r.eu-west-1.awstrac…
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Thankful to @NICHD_NIH for awarding us a new R01 grant on our mRNA lipid nanoparticle pregnancy research led by @SwingleKelsey @hannahsafford_ @HannahGeisler_! We are recruiting postdocs and PhD students in women's health and nanotech, contact us via email or at #BMES2024!
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Had a wonderful time presenting my first conference talk at the Notch GRS/GRC @GordonConf! Excited to now be part of such a scientifically vibrant and close-knit community. Looking forward to organizing the next meeting with Marlene Assfalg, Emma Andersson and @WRgordonlab!
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