@TataMemorial @UVA @IISERPune | Curious about Cells, Art, Music & More | All opinions are personal | bnraj at bluesky | Pune KNoT

Pune, India
Joined July 2018
It is special for the authors of these related AXL-Golgi studies to have their work featured on the cover for both. Congrats @ArnavSaha19, Prachi, @Tush96rkhane ! Thanks @BiologyOpen and @J_Cell_Sci Thanks @ANRFIndia and @IISERPune
The AXL-Golgi story... has two parts, both of which are now published. 1) AXL receptor tyrosine kinase regulates Golgi organization and function via an adhesion-Arf1 signaling axis in breast and lung cancer cell lines tinyurl.com/AXLGolgi1 @BiologyOpen 2) Differential AXL expression and Arf1 regulation control stiffness-dependent Golgi organization in breast cancer cells tinyurl.com/AXLGolgi2 @J_Cell_Sci Together, they make for a comprehensive story identifying the role of AXL in controlling Golgi organization and its regulation by mechanosensory cues (matrix stiffness). Work started as a simple screen by Prachi to pick AXL as a gene of interest, taken forward by @ArnavSaha19 and @Tush96rkhane. Supported ably by many others. It's also nice to be able to use data from Vibhas's @SVibha1 studies in this paper, as she identified the adhesion-Golgi connection many years ago. Congratulations to all involved in this study, which was challenging and exciting in equal measure.
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The joy of discovery! 😊
Amul’s marketing mantra is ‘make cool products and tell no one about it’
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Nagaraj Balasubramanian retweeted
Delighted to announce the appointment of Dr CS Pramesh as President-elect @UICC for 2026-2028. He takes office as President UICC in Oct 2028. Recognized globally for advancing access, quality, and equity in cancer care particularly in LMIC's, his leadership will strengthen systems worldwide. @cspramesh @TataMemorial
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Well said indeed.
#WATCH | Berlin, Germany | Union Minister Piyush Goyal says, "Who's responsible for this mess in the first place? Where did the ozone layer get damaged? Who sent all that carbon into the atmosphere?... I represent 17% of the world's population, but my contribution to global carbon emissions is less than 3%. You (Europe) represent probably 3% or 4% of the world's population, yet your contribution to those carbon emissions—or this mess—is humongous...The problem was caused by you...Even today, as we sit here, my per capita contribution to carbon emissions is probably less than 10% or 15% of yours. Even today, Europe's per capita contribution to carbon emissions—and its per capita environmental impact—is probably seven or eight times that of India...I'm representing 17% of the world's population, and I am more conscious of waste and the circular economy. I also have to meet the needs of 1.4 billion people. I have to meet their energy needs, their food needs, and ensure that my nation remains secure. Despite all of that, we have one of the world's fastest-growing clean energy programmes..." (Source: Piyush Goyal Social Media Page)
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Nagaraj Balasubramanian retweeted
I think there's a lot of misunderstanding about AI causing dangerous runaway biorisk. Here's what I said to a worried colleague: I think there are three aspects of this that are important. Firstly, there's lots of things in biology that are just unknown and for which we don't have the data, and the attrition rate is so high that neither humans nor AI can do very well. Drug discovery is a spectacular example - most things just don't work, and we are always swimming in a sea of ignorance. Secondly, lab work is extremely messy and prone to false positives and negatives and things just not working. AI can help accelerate some of this work - I have been part of such projects myself - but we are very far from AI being able to autonomously orchestrate any kind of risky work in a way that poses unknown dangers, except those that would arise from accidents (glassware and robotic arms breaking, chemicals being mixed unintentionally). Thirdly, all the autonomous biological discovery that I am seeing is almost exclusively computational and falls into two categories: discovery with a human strongly in the loop, and discoveries where AI has sped up an already well-understood process. That being said, I agree that it's a good idea to sandbox or gate AI for biology or chemistry experiments with a strong human-in-the-loop component, but more so in my mind because it could spend valuable capital chasing minor goals or cause dumb accidents rather than design a supervirus autonomously or anything like that. I am also in favor of pausing new model development for, say, a year while we discuss future potential biorisk and agree on international safeguards, the way it was done at Asilomar with recombinant DNA technology in the 70s. I think the bigger issue in some sense for me from an optics standpoint is that if tomorrow a bad actor designs a gain-of-function mutation "using AI", even if it just means speeding up an existing process or doing literature searches faster or better - basically stuff they could have done without AI - the alarmists are going to yell, "We told you so!"
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Nagaraj Balasubramanian retweeted
Congratulations to @cspramesh on his successful election to the Presidentship of the International Union for Cancer Control. He takes office in 2028 and serves on the Board as President-elect. Pramesh is Director of Tata Memorial Hospital, Mumbai, and Professor and Head of Thoracic Surgery at Tata Memorial Centre. He is also Convener of the National Cancer Grid, a network of over 400 cancer centres, research institutions and patient advocacy groups. He already sits on the boards of UICC and ASCO. Pramesh is accessible and proactively helpful in his official role as well ass outside. A well-deserved recognition, which comes with many tough demands: Which he will surely meet
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Do check out and spread the word !
Announcing the fourth edition of the SURGE workshop. This all expenses paid 7-day long workshop is for SC/ST/OBC/EWS/Women students studying in a Master's course in institutes located in non-metro cities. sites.google.com/acads.iiser… Kindly help in spreading the word.
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Nagaraj Balasubramanian retweeted
My dear friends, please, I hope to demand your absolute attention to this matter: In 2018, my junior from St. John’s Medical College, Bengaluru, Dr. Randall Sequeira (middle in the pic), trekked up a steep, bauxite-rich plateau in Odisha to hold a monsoon health camp in the indigenous Kutiya Kondh village of Kutrumali. In a piece he wrote then titled "Kutrumali’s Demons," Randall described sleeping under a dripping school roof in freezing fog, borrowing utensils from a local health worker to cook khichdi, and waking up at 6 AM to a line of tribal mothers. He wrote with heartbreak about treating malnourished toddlers with protruding bellies and visible ribs, listening to stories of stillbirths and chronic fevers, while noticing the shiny new solar lights installed by a mining conglomerate eyeing the aluminium ore beneath the villagers' feet. Comparing his small medical team to hobbits sheltering in the night, Randall worried about the outside forces coming for that fragile village. Randall stayed with the tribal/ adivasi community to serve them. After St. John’s and an MD in Internal Medicine from SMS Jaipur, he gave up every comfort of urban medicine to live in Kalahandi, recognizing that clinical prescriptions are meaningless when indigenous communities are stripped of their forests, water, and dignity. On the night of October 16, Odisha police picked up Dr. Randall Sequeira and Dalit activist Laxman Naik at 11 PM from his home in Bhawanipatna. A gentle physician who has spent years trekking up hills to save tribal children is now locked in Rayagada sub-jail under frivolous but draconian charges (attempt to murder, dacoity), simply for standing with Adivasis peaceful protesting the mining of their sacred hills in Sijimali and Kutrumali. thewire.in/rights/randall-se… Odisha Govt. said it will cut down forests to connect tribal villages. But it was a way to bypass green laws and fast track London based Vedanta’s, and Adani's mining plans. Local organisations estimate that around 45 villages depend on these hills and would be affected. reporters-collective.in/trc/… The state has answered with repression rather than dialogue. In the last three years, at least 43 police cases have been filed and over a hundred Adivasis and Dalits, both women and men, have been incarcerated in Odisha jails. For example, from In March and april 2026, 8, 2026, to April 8, 2026, within one month, 24 people were sent to jail, 217 were made accused, and the number of “others” total 1,140. An activist who was not named in the original FIRs, but has since been implicated in about 12 cases, so that bail in one case is followed by arrest in another. This pattern of capture and releases have been used to crush rational dissent. Dr. Randall understood that being a good doctor means understanding that prescriptions cannot compensate for the denial of land rights, that surgery cannot undo displacement and that no medical can substitute for the basic infrastructure a government has failed to provide. thehindu.com/sci-tech/health… To my fellow medical fraternity, and every citizen with a conscience: a kind physician who embodies the highest ethics of our profession is being criminalized to clear the way for bauxite mining. Please do not let his voice be buried in a sub-jail. Amplify this, demand due process, and demand the immediate release. Please sign in this form to show solidarity: forms.gle/o2Rj2Uu3tXaoWu9dA If anyone can help out in this situation please reach out to Medico Friend Circle - mfcindia.org/
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50 years ago The Selfish Gene became an instant bestseller, bringing evolutionary biology back into cultural conversation and catapulting its author, Richard Dawkins, to global fame. Yet today scientists are still debating its core message. sciam.com/article/the-selfis…
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Nagaraj Balasubramanian retweeted
almost two weeks to go, please consider donating to my dana farber boston half marathon fund raiser. danafarber.jimmyfund.org/sit…
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Nagaraj Balasubramanian retweeted
Walker Vickers and Maitreyi Das discover that memory of growth promotes early Ras #GTPase activation to establish dominance of inherited cell ends in S. #pombe. journals.biologists.com/jcs/…
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Nagaraj Balasubramanian retweeted
What does it take to reinvent bone healing for millions of patients? Hear it from the team behind SERIOSS®, the world’s first silk protein-based bone void filler, now CDSCO-approved for manufacturing & sale in India. Order here: [email protected] (1/2)
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Nagaraj Balasubramanian retweeted
Harper Lee, To Kill a Mockingbird.
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In their Tools & Resources article, Bruno Saraiva, Guillaume Jacquemet, Ricardo Henriques @HenriquesLab and team introduce Rxiv-Maker, their automated template engine for streamlined scientific publications. journals.biologists.com/jcs/…
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Nagaraj Balasubramanian retweeted
My book will be available in stores from this week. Meanwhile, happy to see that it is the Number 1 bestseller in the economic policy section of Amazon.
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The Ghosh Lab at NCBS-TIFR invites applications for a postdoctoral fellow and PhD student to investigate the mechanisms of brain resilience. Apply by 30 Oct 2026. @hiyaa_ghosh
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Thought provoking read in today’s time. Milligrams experiments and more. “Those who obeyed tended to give the main responsibility to the experimenter. Those who refused tended to say that the main responsibility lay with themselves.” “If the experimenter had said, "why don't you take 10 minutes to think about what to do?", there would probably have been more disobedience, Burger believes. A pause would have given volunteers the chance to ask themselves: "Is this right or wrong, am I the kind of person who does this?" bbc.com/future/article/20261…
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