Alis Olea (@AlisOlea) header
Alis Olea (@AlisOlea) profile picture

Alis Olea

@AlisOlea

🔬PhD student @n4nlab #superresolutionmicroscopy & #nanoparticles @IbecBarcelona

 Barcelona, Spain
Joined March 2017
  • Tweets42
  • Following109
  • Followers66
Happy to share that our long-awaited micelle article is finally published, proposing a simple 3D chip setup for assessing the mobility of polymeric micelles through the tumor ECM. Thank you so much @Fluo_renzo and @RoeyJAmir for the continuous support! doi.org/10.1021/acsami.3c127…
Reaching the Tumor: Mobility of Polymeric Micelles Inside an In Vitro Tumor-on-a-Chip Model with...

Reaching the Tumor: Mobility of Polymeric Micelles Inside an In Vitro Tumor-on-a-Chip Model with...

Abstract. Degradable polymeric micelles are promising drug delivery systems due to their hydrophobic core and responsive design. When applying micellar nan

pubs.acs.org
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Unlike books, together with @n4nlab (@Fluo_renzo) and @Hoogenboomgroup, we used Dendritic Amphiphiles with Different Hydrophilic Blocks for Judging Micelles by Their Covers pubs.acs.org/doi/10.1021/acs…. Great Job @GadiSlor and @AlisOlea (@theracatEU)
Judging Enzyme-Responsive Micelles by Their Covers: Direct Comparison of Dendritic Amphiphiles with...

Judging Enzyme-Responsive Micelles by Their Covers: Direct Comparison of Dendritic Amphiphiles with...

Abstract. Enzymatically degradable polymeric micelles have great potential as drug delivery systems, allowing the selective release of their active cargo a

pubs.acs.org
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🚨2021 came with an exciting publication from our lab: ‘Real-Time Ratiometric Imaging of Micelles Assembly State in a Microfluidic Cancer-on-a-Chip’ from @FgrNats & @a_mareska 👏🏼@AIMBiotech @RoeyJAmir @shirubianomono @Fluo_renzo @TUeindhoven @IBECBarcelona pubs.acs.org/doi/10.1021/acs…
Real-Time Ratiometric Imaging of Micelles Assembly State in a Microfluidic Cancer-on-a-Chip

Real-Time Ratiometric Imaging of Micelles Assembly State in a Microfluidic Cancer-on-a-Chip

Abstract. The performance of supramolecular nanocarriers as drug delivery systems depends on their stability in the complex and dynamic biological media. A

pubs.acs.org
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The first paper of @theracatEU project is out!👏👏👏 It’s about micellar disassembly and enzymatic degradation of amphiphiles. Check this nice piece of work lead by @RoeyJAmir with the participation of @shreyaswagle93 👇👇 pubs.acs.org/doi/abs/10.1021…
Image from THERACAT project (@theracatEU)
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At @BOOMchemistry we use TMCs to release #prodrugs 💊 Preliminary, TMC activity can be measured over time with #fluorophores!! Today our #chemistree has been decorated with catalytically turned-on #prodye "cleavaBalls" 🎄 #Transition #Metal #Catalysis #bioorthogonal #chemistry
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Our preprint on Quantitative nanomedicine is out! 💊🎯 great collaboration with Nick Tito to understand targeted nanomedicines using quantitative theoretical and experimental methods sciencedirect.com/science/ar… @ADDReditors @wth_laura #nanomedicine #drugdelivery #multivalency
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Sprouting of mCherry EMT6 cells tumor spheroids shows the aggressiveness of BRCA mutated breast cancers. #3D #Biology #breastcancer #CancerResearch ⁦@RSFLab⁩ ⁦@AjamilR⁩
Image from THERACAT project (@theracatEU)
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Using super-resolution microscopy on nanoassemblies, we can unravel unprecedented details, showing the heterogeneity in molecule number and architecture on a single-particle level. Here an image from previous research on polyplexes (scale bar 2 µm) 🔬 @AlisOlea @n4nlab
Image from THERACAT project (@theracatEU)
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Funny how images of faraway galaxies look very similar to those of nanoparticles on a glass slide in widefield TIRF microscopy (the brighter ones are usually aggregates)✨🔬 @AlisOlea @n4nlab #stargazing at the #nanoscale
Image from THERACAT project (@theracatEU)
Space Telescope Live (@spacetelelive) profile pictureSpace Telescope Live@spacetelelive13 Nov 2020
I am looking at the Star AV-343 with Space Telescope Imaging Spectrograph for Dr. Derck L. Massa. spacetelescopelive.org/2020-…
Image from Space Telescope Live (@spacetelelive)
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Amazing image of @biogelx gels structure 🤩 @AlisOlea @n4nlab #confocalmicroscopy
Image from THERACAT project (@theracatEU)
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My PhD is part of the #THERACAT consortium, developing bioorthogonal catalysis for cancer therapy. In particular, my project is about #imaging the delivery of #nanocatalysts and prodrugs to the tumor site.
THERACAT project (@theracatEU) profile pictureTHERACAT project@theracatEU23 Oct 2020
Replying to @theracatEU
@theracatEU is based on innovative THERApeutic CATalysts science (1/2): materials bearing a catalytic unit are delivered to the #tumor and afterwards non-active prodrugs are administered to the patient and become active only in the sites where the catalytic units are functional
Image from THERACAT project (@theracatEU)
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Interested in #medical and industrial applications of #microfluidic-based cell/tissue culture and #organs-on-a-chip? Read and download this article collection here: fro.ntiers.in/BxbC Lead by researchers from A*STAR, @DTUtweet and Academia Sinica #toxicology #cellculture
Image from Frontiers - Bioengineering and Biotechnology (@FrontBioeng)
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🚨🎬Take a look at @a_mareska ‘s video describing her work on microfluidic technology facilitating drug screening that will be presented the 13th #IBECSymposium ‘Bioengineering for Future Medicine’ 27-28th OCT. Vote with a like to support! @IBECBarcelona youtube.com/playlist?list=PL…
IBEC Symposium 2020 - Poster Videos

IBEC Symposium 2020 - Poster Videos

Vote for the best video of this year's IBEC symposium! The winning video will be the one with more likes!

youtube.com
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An important problem that's way too often overlooked in single molecule or super-res studies is the potential influence of membrane topology. Another contribution from Ingela Parmryd on this essential point: frontiersin.org/articles/10.…
Frontiers | Variations in Plasma Membrane Topography Can Explain Heterogenous Diffusion Coefficie...

Frontiers | Variations in Plasma Membrane Topography Can Explain Heterogenous Diffusion Coefficie...

Fluorescence correlation spectroscopy (FCS) is frequently used to study diffusion in cell membranes, primarily the plasma membrane. The diffusion coefficient...

frontiersin.org
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🚨🚀We proudly present our new website! n4nlab.eu 🥳🖥️ A platform to unify our group efforts delocalized between @IBECBarcelona and @TUeindhoven 📌 A special thanks to @AlisOlea for her beautiful design 😍
Image from Nanoscopy for Nanomedicine lab (@n4nlab)
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Our latest paper is out on BioRxiv! Great work of @FgrNats and @a_mareska that combined spectral imaging with organ-on-a-chip to track nanoparticles along their path towards cancer cells. Does your NP survive this voyage? Microscopy will tell you! @n4nlab biorxiv.org/content/10.1101/…
Real-time Ratiometric Imaging of Micelles Assembly State in a Microfluidic Cancer-on-a-chip

Real-time Ratiometric Imaging of Micelles Assembly State in a Microfluidic Cancer-on-a-chip

The performance of supramolecular nanocarriers as drug delivery systems depends on their stability in the complex and dynamic biological media. After administration, nanocarriers are challenged by...

biorxiv.org
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❕❗️Be our new colleague! N4N is looking for a new PhD in Eindhoven that will work on superesolution microscopy to characterise nanoparticles 🧪🔬 RT please jobs.tue.nl/en/vacancy/-phd-…
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My illustration was for the first time on the big screen today! showing the focus of our group @n4nlab on the different steps in the journey of nanoparticles through the body, presented by dr. Silvia Pujals in the @NanoBioMedConf Thank you @shirubianomono
Nanoscopy for Nanomedicine lab (@n4nlab) profile pictureNanoscopy for Nanomedicine lab@n4nlab19 Nov 2019
Live at the @NanoBioMedConf! Dr Silvia Pujals is sharing her work and knowledge on how Super-Resolution Microscopy can be used as a tool to tackle challenges in nanomedicine 🔬👩🏻‍🔬 All eyes on you Silvia! 🤓😎 @shirubianomono @n4nlab @IBECBarcelona @Fluo_renzo #NanoBioMedConf 🥳🥳
Image from Nanoscopy for Nanomedicine lab (@n4nlab)
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An interesting use for "junk DNA" - making new genes
Nature Portfolio (@NaturePortfolio) profile pictureNature Portfolio
@NaturePortfolio19 Oct 2019
Conventional wisdom on evolution was that new genes tended to arise when existing ones are accidentally duplicated, blended with others or broken up. Some researchers, however, now think that de novo genes could be quite common. go.nature.com/35HOBvL
The Illuminating Geometry of Viruses quantamagazine.org/the-illum… via @QuantaMagazine
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