Interested in cryoEM, cytoskeleton, and mechanosensation at the molecular level.
New York, USA
Joined October 2017
- Tweets678
- Following665
- Followers1.5K
- Likes1.5K
Alushin_Lab retweeted
1/5 Cryo-EM gives high-resolution RNA structures, but only when high Mg²⁺ freezes out their motion.
At physiological conditions, RNAs are dynamic and 3D reconstruction fails. Can we still learn their folding equilibria?
New preprint: yes, straight from the raw particle images👇
Alushin_Lab retweeted
*Job alert*: Postdoc position at the Flatiron Institute to work on biophysical inference and cryo-EM. ❄️ 🔬Applications are welcome! apply.interfolio.com/193799
Alushin_Lab retweeted
Looking for a faculty position combining research in fundamental cell and molecular biology with therapeutic discovery?
Join our amazing faculty at the @weillinstitute at @Cornell University in Ithaca, New York.
academicjobsonline.org/ajo/j…
Apply by Nov. 15!
Please share!
Alushin_Lab retweeted
We are hiring! 🌟 Dept of Biochemistry and Molecular Biology at the University of Chicago is searching for a tenure-track assistant professor. It's a broad search: we want great colleagues doing serious biological work at the molecular scale. Please share!
apply.interfolio.com/191981
Alushin_Lab retweeted
MCB is hiring Assistant Professors across 3 divisions!:
🧪 BBS: aprecruit.berkeley.edu/JPF05…
🧬GGED: aprecruit.berkeley.edu/JPF05…
🦠IMM: aprecruit.berkeley.edu/JPF05…
🗓️ Application Deadline: October 19, 2026
🔗 Click the links or scan the QR codes to learn more and apply
ALT MCB is hiring 3 Assistant Professor positions across 3 divisions: Biochemistry, Biophysics and Structural Biology (BBS); Genetics, Genomics, Evolution, and Development (GGED); and Immunology and Molecular Medicine (IMM) BBS application link: https://aprecruit.berkeley.edu/JPF05483 GGED application link: https://aprecruit.berkeley.edu/JPF05481 IMM application link: https://aprecruit.berkeley.edu/JPF05486
ALT Assistant Professor of Immunology and Molecular Medicine. IMM application link: https://aprecruit.berkeley.edu/JPF05486
ALT Assistant Professor of Biochemistry, Biophysics and Structural Biology (BBS). BBS application link: https://aprecruit.berkeley.edu/JPF05483
ALT Assistant Professor of Genetics, Genomics, Evolution, and Development (GGED). GGED application link: https://aprecruit.berkeley.edu/JPF05481
Alushin_Lab retweeted
Faculty opening in Basic Sciences @fredhutch! Egalitarian and supportive environment:
🔬 Fred Hutch Cancer Center is hiring an Assistant or Associate Professor in the Basic Sciences Division @HutchBasicSci. Join a world-class research community in Seattle and help advance discoveries in fundamental biology. Apply: apply.interfolio.com/190640
Alushin_Lab retweeted
Characterizing AI-designed proteins requires quantitative biochemistry at massive scale. Enter Amplicon/Protein Bead Display (APB-Display), a fully in vitro platform that quantifies Kd's for >100,000 variants in <3 days (preprint link below!) @Stanford_ChEMH @czbiohub (1/n)
Alushin_Lab retweeted
Amazing work from the Kellogg lab!! I had this kind of project in my very first 2022 professorship proposal and but never actually did it, super glad to see it can work in reality!!!
biorxiv.org/content/10.64898…
Alushin_Lab retweeted
How do cells convert mechanical information into a molecular process? The @Alushin_Lab has captured the first snapshot of a mechanical signaling complex in action, findings in @Nature that have implications for disorders related to myosin dysfunction.
🔗: bit.ly/41Kshjw
Very pleased that after a rigorous (and lengthy) review process, our paper visualizing how myosin generated forces modulate actin filament structure for mechanosensitive recogntion by α-catenin has appeared in @Nature
nature.com/articles/s41586-0…
After additional work, we believe that it is exclusively axial compression which produces supercoils. Compression can occur on a subset of filament segments even under conditions which globally produce tension, due to the stochastic mechanochemical cycles of uncoupled motors.
We thank the reviewers for their insightful comments which clarified many additional aspects of the paper beyond this key point. Congrats to co-first authors Ayala Carl, Matt Reynolds @mattabolic_rate , and Xiaoyu Sun @XiaoyuSun_LIM !
Very excited to share our latest preprint, where we visualize the impact of force on the catch bonding actin crosslinker α-actinin-4. Led by @alfredcchin, a great collaboration with Glen Hocky's lab.
biorxiv.org/content/10.64898…
Cytoskeleton enthusiasts: join us for the Cytoskeletal Motors GRC, July 12-17, 2026, in Portland Maine. Abstracts submitted by April 5 will be considered for short talks. Please apply!
bit.ly/4cWxvzj
Alushin_Lab retweeted
Scientists in the @Alushin_Lab figured out how cells build a structure that lets them migrate. Unpacking these “finger-like” protein bundles that protrude from cells may lead to novel treatments for #metastasis. #RockefellerScience #YearInReview
🔗: bit.ly/3PKErmA
Alushin_Lab retweeted
DNA nanodevice for analysis of force-activated protein extension and interactions.
A tension-modulated #DNAorigami #nanosensor, compatible with bulk biochemical analysis in cell lysates, is used to assess the force-induced interaction of proteins.
nature.com/articles/s41565-0…
Alushin_Lab retweeted
🚨Today in @NatureComms: We resolve an enduring enigma in T cell biology—how TCR binding to p/HLA triggers intracellular signaling. CryoEM in native environment reveals a 'jack-in-the-box' mechanism! Collab btw @RockefellerUniv @MSKCancerCenter @parkerici rdcu.be/eUPPl
Alushin_Lab retweeted
How do cells move, divide, and sense their surroundings? The answer lies in the cytoskeleton--and when it malfunctions, cancer and birth defects follow. @Alushin_Lab at @RockefellerUniv has developed new tools to probe this tiny, dynamic cell scaffolding.
rockefeller.edu/news/38446-h…
Alushin_Lab retweeted
nature.com/articles/s41567-0…
The latest research article from the Ti Lab is finally out today in Nature Physics.
