The other side of ASCO 2026. Used Gen AI to synthesize ASCO 2026 KOL negative commentary into a simple signal map.
Ankit Kalucha retweeted
NEW ASCO Guidelines Assistant tool leverages Google Cloud Vertex AI platform & Gemini models, enabling oncology clinicians to quickly access evidence-based clinical guidelines.
Ankit Kalucha retweeted
Immune cell effector-associated neurotoxicity syndrome (ICANS) is a less well understood entity related to cytokine disruption of BBB and comprising diverse neurological symptoms. ICANS was rare (<10%) and no ICANS 3 or more was observed. (pic from Sands Cancer 2024)
🧵12/15
Do ΔORR and ΔDoR Predict PFS and OS Hazard Ratios Across Cancer RCTs? #CancerTrials #RCTs #MedicalAI
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Deep research cost evaluation of the recent Stage IV NSCLC With Driver Alterations: ASCO Living Guideline v2024.3 #nsclc #ASCO #lungcancer #Oncology
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Generative Reward Models Self-Taught Reasoning (STAR) in AI Training for cancer clinical trials
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Ankit Kalucha retweeted
Biomarkers, Molecular Targets, and Methods of Detection for Precision Medicines in NSCLC
(ESMO guideline)
Ankit Kalucha retweeted
🫁 NCCN guideline updated 🫁
🫁 Part-1, NSCLC 🫁
🌟 Version 9.2024 — September 9, 2024 🌟
📌 Ver. 8 was updated on August 23, 2024, so went to ver. 9 in about 2 weeks, right in the middle of WCLC 2024.
Ankit Kalucha retweeted
🫁 Lung Cancer - ICIs data 🫁
🌟 Summary of 5-year (long follow-up) data
🌟 NSCLC (NSQ & SQ)
#Immunotherapy
#Lungcancer
#longfollowup
#LCSM
Ankit Kalucha retweeted
Seems like Ontologies are back
- 20 years ago, ontologies were gaining traction. W3C OWL became a standard
- 10 years ago it was a red flag. Don’t say the “o word”
- Now w/ LLMs, we have the need to manage knowledge in a structured & governed manner
What comes around, goes around
Ankit Kalucha retweeted
🎯PFS-2 is a better surrogate for OS than PFS in advanced cancer trials 🔥 👉 PFS-2 has a stronger correlation with OS benefit (r = 0.70 vs r = 0.46)
🤔Should PFS-2 be the primary endpoint in future trials???
@ASCO @myESMO @eaonc @SWOG @EORTC @VPrasadMDMPH @VincentRK
#PFS2 #OS #CancerResearch
ascopubs.org/doi/10.1200/PO.…
Ankit Kalucha retweeted
Summary of 5 new drugs/indications in GI malignancies that were @FDAOncology @US_FDA approved in 2023:
- #Tucatinib - Mountaineer
- #TAS102 + #Bevacizumab - Sunlight
- #Pembro + Cis/Gem - KN966
- #Fruquintinib - FRESCO2
- #Pembro + Chemo - KN859
#OncTwitter #gism #crcsm
Summary of the 4 new drugs/indications that were approved for GI malignancies by @FDAOncology in 2022:
- Nivo & Ipi/Nivo
- Durvalumab
- Futibatinib
- Treme + Durva
#GastricCancer #MedEd @OncoAlert @ASCO #GIOncology #CRCSM #MedTwitter #OncTwitter #Oncology #gism
Ankit Kalucha retweeted
🎆🎯2023 FDA approvals.
👉🏼The FDA approved 55 novel therapeutics in 2023, the second highest count in the past 30 years 🙌🏼
👍🏼The FDA’s Center for Drug Evaluation and Research (CDER) approved 55 new drugs in 2023, as the small molecule and biologic pharmacopoeia continues to grow @tmprowell @FDAOncology @US_FDA @OncoAlert @NatRevDrugDisc @statnews
nature.com/articles/d41573-0…































