Physician-scientist & molecular hematopathologist at Weill Cornell Medicine
Manhattan, NY
Joined October 2018
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Pls RT: The Nam Lab at WCM is recruiting post-doctoral fellows to join the growing team!
If you're interested in deciphering blood cancers through advanced single-cell technologies, please DM me and visit our website annanamlab.com to learn more.
Please check out this insightful perspective on our study from the super talent @AlbaRMeira! Many thanks Alba!
Super excited that my News and Views, highlighting the beautiful work from the Nam lab, is now out in @NatureGenet ! Interferon alpha directs hematopoietic stem cells towards competing fates. Check it out here: rdcu.be/RT7N7mmHh8va big thanks @SafiaDanovi for the opportunity
Anna Nam retweeted
Beyond thrilled that the first paper from our lab is out today in @nature! We show that SWI/SNF loss results in gain-of-function for CTCF and cohesin, reshaping the 3D genome, and an unexpected switch between chromatin remodeling complexes.
nature.com/articles/s41586-0…
1/n
Anna Nam retweeted
1/8 Abnormal neurons in the developing brain: ~26% of human fetal cortical neurons carry widespread, multi-chromosome CNVs. Most of these genomically aberrant neurons are eliminated right around birth, not gradually over a lifetime. 🧵doi.org/10.1038/s41586-026-1… @Nature
Anna Nam retweeted
Faculty ad is out,
please help spread the word
Come #DreamBig together, without a doubt,
in the best city in the world!
jobs.sciencecareers.org/job/…
🚨We're recruiting! Calling all bold & original thinkers! Folks with imagination, drive & the (rare) ability to find the thin seam where the fantastical and real meet. Come join a thriving science community, in, beyond a shadow of a doubt, the greatest city in the 🌎 @nyknicks
Anna Nam retweeted
Today in @Nature we present the development and characterisation of the first-in-class catalytic inhibitor of METTL1 as a new therapeutic strategy against solid and blood cancers.
Another flagship collaboration between my lab @SCICambridge @Cambridge_Haem (@Cambridge_Uni) and @storm_tx, co-led by my brilliant colleague @OliverRausch and driven by Eliza Yankova, Alexandra Sapetschnig and Beth Thomas.
A big thank you to the long list of authors who participated in this study and provided their critical input and diverse expertise. I am also very thankful and lucky to have the continuous support of @wellcometrust, @LeukUK and @CR_UK.
nature.com/articles/s41586-0…
Anna Nam retweeted
Excited to share our new preprint! ChromE-seq reads 3D chromatin and gene expression in one cell. Across ~400,000 human primary cells, B lineage has the fewest chromatin loops and is most perturbed in trisomy 21, driving the B-cell block in Down syndrome.
biorxiv.org/content/10.64898…
Anna Nam retweeted
Proud to have contributed to newly published 2026 @ASH_hematology Guidelines for Myelofibrosis!
10 evidence-based recs spanning molecular testing, JAK inhibitors, anemia & transplant.
📄 doi.org/10.1182/bloodadvance…
#Myelofibrosis #MPN #Hematology #ASHGuidelines #BloodAdvances
Anna Nam retweeted
Danielle Isakov, Chhiring Lama, and scientists at @WeillCornell found that interferon-α reshapes hematopoietic stem cell differentiation in #myeloproliferative neoplasms, while disease-causing mutations alter how stem cells respond to treatment. 🩸
🥼 go.nature.com/4AiXtX5
🎧 Join the conversation: bit.ly/4yiewap
Anna Nam retweeted
After many years of effort, deliberation, excitement, angst, joy, and Wednesday afternoon lab lunches, our group's first manuscript on cachexia, led by Venise Jan Castillon, Amy Xie, and really our whole lab nature.com/articles/s41591-0… @NatureMedicine
Anna Nam retweeted
Thrilled to post thread re: new single-cell lineage of mouse embryo reconstructed w/ DNA Typewriter. One animal, zygote to late organogenesis (E13.5). Tree has 1,340,794 transcriptionally profiled, annotated tips (cells), 1,142,588 dated internal nodes, rooted at zygote
1/n
Anna Nam retweeted
Delighted to share RNA fingerprinting, out today in @CellCellPress! Together with @david_a_knowles , we use Perturb-seq experiments—where the causal perturbation is known—to infer what drives cellular responses in new datasets: cell.com/cell/abstract/S0092…
Anna Nam retweeted
Exciting day for DNA Typewriter w/ 2 papers from the lab & SeaHub out today :)
1. Mouse lineage from E0 to E13.5
science.org/doi/10.1126/scie…
2. A fluctuation test for gastruloid heterogeneity
cell.com/cell/fulltext/S0092…
Paper #1 covered in quoted thread. More on paper #2 here. 1/n
Anna Nam retweeted
Benchmarking with Honesty | S1 E1
The Life & Science Podcast 🫶
open.spotify.com/episode/2eO…
Anna Nam retweeted
Ever wonder if tRNAs can regulate the identity of a cancer cell?
@HsiehLab @FredHutch postdoc @yeonsookim_phd did and discovered a single tRNA that can control lineage dependency and drug sensitivity in prostate cancer published today @Nature: nature.com/articles/s41586-0…
Anna Nam retweeted
Big news today: I am deeply honored to receive the NIH Director's Pioneer Award, one of only seven given this year across all fields! We will build an AI engine that generates cancer hypotheses from human data and tests them with robots in tumor organoids news.weill.cornell.edu/news/…
Anna Nam retweeted
🧬 Happy to share our new study in @BloodAdvances! Many inherited cancer predisposition genes only cause disease once a second mutation arrives. We tested that directly, combining CRISPR editing of human primary blood stem cells with xenotransplantation.🧵doi.org/10.1182/bloodadvance…
Anna Nam retweeted
Chemotherapy and ionizing radiation are known to promote clonal hematopoiesis and its progression to leukemia. By inducing temporary quiescence of hematopoietic stem cells during external stress might we mitigate CH expansion? We address this through a collaboration with @AbdelWahablab @PuZhang09980432: nature.com/articles/s41588-0…. Excited to share this and some thoughts from a recent meeting in Hiroshima which puts this work in a broader perspective.
Anna Nam retweeted
🩸🧬 Delighted to share our new @Nature paper! Genetic studies of >28,000 people reveal a BACH2–NRF2 pathway for activating fetal hemoglobin, suggesting new tx avenues for sickle cell disease & β-thalassemia. Led by the amazing @guo_chunjie & co!
nature.com/articles/s41586-0…
Anna Nam retweeted
What happens to the bone marrow niche in #CHIP? We find that CHIP is associated with fibro-inflammatory hubs emerging before the disease.
Co-led by our fantastic @aliciaguilar_ and @gibran_edun
nature.com/articles/s41590-0…
#ClonalHematopoiesis #PreTumorMicroenvironment #Hematopoiesis
Anna Nam retweeted
Congratulations to Sweta and the rest of the team on our new publication in @BCD_AACR exploring the dependence and therapeutic targeting of NAMPT in high-risk MDS stem cells. Thanks to @BloodCancerUtd and Evans Foundation for support! aacrjournals.org/bloodcancer…
