Differential regulation of histamine H1 receptor-mediated ERK phosphorylation by Gq proteins and arrestins pubmed.ncbi.nlm.nih.gov/3720… #GPCR #signaling #pharmacology

Correction to "Cannabinoid Tolerance in S426A/S430A x β -Arrestin 2 Knockout Double-Mutant Mice" pubmed.ncbi.nlm.nih.gov/3719… #GPCR #signaling #pharmacology

Detection, chemical analysis, and pharmacological characterization of dipyanone and other new synthetic opioids related to prescription drugs pubmed.ncbi.nlm.nih.gov/3717… #GPCR #signaling #pharmacology

Distinct Profiles of Desensitization of µ-Opioid Receptors Caused by Remifentanil or Fentanyl: In Vitro Assay with Cells and Three-Dimensional Structural Analyses pubmed.ncbi.nlm.nih.gov/3717… #GPCR #signaling #pharmacology

Conformational dynamics of the μ-opioid receptor determine ligand intrinsic efficacy pubmed.ncbi.nlm.nih.gov/3716… #GPCR #signaling #pharmacology

Plasma membrane preassociation drives β-arrestin coupling to receptors and activation pubmed.ncbi.nlm.nih.gov/3714… #GPCR #signaling #pharmacology

A novel CCR6 antagonist (PF-07054894) that distinguishes between homologous chemokine receptors, increases basal circulating CCR6+ T cells, and ameliorates interleukin-23-induced skin inflammation pubmed.ncbi.nlm.nih.gov/3714… #GPCR #signaling #pharmacology

Divergent acute versus prolonged pharmacological GLP-1R responses in adult β cell-specific β-arrestin 2 knockout mice pubmed.ncbi.nlm.nih.gov/3713… #GPCR #signaling #pharmacology

Dual-Acting Small Molecules: Subtype-Selective Cannabinoid Receptor 2 Agonist/Butyrylcholinesterase Inhibitor Hybrids Show Neuroprotection in an Alzheimer's Disease Mouse Model pubmed.ncbi.nlm.nih.gov/3712… #GPCR #signaling #pharmacology

Sex-dependent effects of acute stress on amyloid-β in male and female mice pubmed.ncbi.nlm.nih.gov/3712… #GPCR #signaling #pharmacology

Direct Selection of DNA-Encoded Libraries for Biased Agonists of GPCRs on Live Cells pubmed.ncbi.nlm.nih.gov/3712… #GPCR #signaling #pharmacology

Carteolol triggers senescence via activation of β-arrestin-ERK-NOX4-ROS pathway in human corneal endothelial cells in vitro pubmed.ncbi.nlm.nih.gov/3712… #GPCR #signaling #pharmacology

A 5-year-old Syrian female was born with Oguchi disease: a rare case report pubmed.ncbi.nlm.nih.gov/3711… #GPCR #signaling #pharmacology

Structural Insights into M1 Muscarinic Acetylcholine Receptor Signaling Bias between Gαq and β-Arrestin through BRET Assays and Molecular Docking pubmed.ncbi.nlm.nih.gov/3710… #GPCR #signaling #pharmacology

Identification of biomarkers, pathways, and potential therapeutic targets for heart failure using next-generation sequencing data and bioinformatics analysis pubmed.ncbi.nlm.nih.gov/3709… #GPCR #signaling #pharmacology

Regulation of the pro-inflammatory G protein-coupled receptor GPR84 pubmed.ncbi.nlm.nih.gov/3708… #GPCR #signaling #pharmacology

Characterization of serotonin-5-HTR1E signaling pathways and its role in cell survival pubmed.ncbi.nlm.nih.gov/3707… #GPCR #signaling #pharmacology

Subcellular location defines GPCR signal transduction pubmed.ncbi.nlm.nih.gov/3707… #GPCR #signaling #pharmacology

ARRDC5 expression is conserved in mammalian testes and required for normal sperm morphogenesis pubmed.ncbi.nlm.nih.gov/3706… #GPCR #signaling #pharmacology

Computational insights into ligand-induced G protein and β-arrestin signaling of the dopamine D1 receptor pubmed.ncbi.nlm.nih.gov/3706… #GPCR #signaling #pharmacology