🧠 Can the 𝑳𝒊𝒐𝒏'𝒔 𝑴𝒂𝒏𝒆 mushroom boost your brain function and memory? A recent study by Martínez-Mármol et al. found that hericerin derivatives from this mushroom activate new neurotrophic pathways. Published in the 𝘑𝘰𝘶𝘳𝘯𝘢𝘭 𝘰𝘧 𝘕𝘦𝘶𝘳𝘰𝘤𝘩𝘦𝘮𝘪𝘴𝘵𝘳𝘺, the study explores the impact of Hericium erinaceus compounds on hippocampal neurons. Using super-resolution structured 𝐢𝐥𝐥𝐮𝐦𝐢𝐧𝐚𝐭𝐢𝐨𝐧 𝐦𝐢𝐜𝐫𝐨𝐬𝐜𝐨𝐩𝐲, the researchers discovered that NDPIH and hericene A help neurons grow and form new connections, showing strong brain-boosting activity. Interestingly, these compounds activate the ERK1/2 signaling pathway without using the usual TrkB receptor. Mice that were given these extracts showed better spatial memory, suggesting potential uses for these compounds in treating memory loss and neurodegenerative diseases. This research highlights the exciting potential of natural compounds in supporting brain health and opens up new possibilities for developing treatments. ☝ #EducationalThursday #Memory #Microscopy

On today's #EducationalThursday, let's get to know more about 𝐬𝐡𝐚𝐫𝐩 𝐰𝐚𝐯𝐞 𝐫𝐢𝐩𝐩𝐥𝐞𝐬, those distinctive patterns of neural activity observed in the brain, particularly during periods of rest and sleep. These high-frequency oscillations, typically occurring in the hippocampus – a region crucial for memory and spatial navigation – are characterized by brief bursts of electrical impulses, followed by a period of relative inactivity. Sharp wave ripples play a vital role in consolidating memories, facilitating information transfer between different brain regions, and regulating neuronal plasticity. Understanding the mechanisms underlying sharp wave ripples sheds light on fundamental processes of 𝐥𝐞𝐚𝐫𝐧𝐢𝐧𝐠 𝐚𝐧𝐝 𝐦𝐞𝐦𝐨𝐫𝐲, offering insights into various neurological disorders and potential therapeutic interventions. The figure is from Judák et al. 2022 (@BVC2021), where they examined the correlation between sharp wave ripples and dendritic spikes. 📚 Read article: t.ly/V1I29 #neuralactivity #brainvisioncenter #dendriticspikes #twophotonimaging #multiphotonmicroscopy

❔ Craving some thought-provoking content for the weekend? Explore our latest preprint on the '𝑪𝒐𝒎𝒑𝒆𝒕𝒊𝒕𝒊𝒐𝒏 𝒐𝒇 𝒄𝒐𝒓𝒕𝒊𝒄𝒂𝒍 𝒄𝒍𝒖𝒔𝒕𝒆𝒓𝒔 𝒅𝒖𝒓𝒊𝒏𝒈 𝒐𝒏-𝒅𝒆𝒎𝒂𝒏𝒅 𝒗𝒊𝒔𝒖𝒂𝒍 𝒍𝒆𝒂𝒓𝒏𝒊𝒏𝒈 𝒊𝒏 𝒊𝒎𝒎𝒆𝒓𝒔𝒊𝒗𝒆 𝒗𝒊𝒓𝒕𝒖𝒂𝒍 𝒓𝒆𝒂𝒍𝒊𝒕𝒚.' 📖 Read preprint here: t.ly/5QUqj What is it about? Introducing the 𝐌𝐎𝐔𝐒𝐄 𝐕𝐈𝐑𝐓𝐔𝐀𝐋 𝐑𝐄𝐀𝐋𝐈𝐓𝐘 𝐒𝐘𝐒𝐓𝐄𝐌 – 𝐕𝐑, a collaborative effort by BrainVisionCenter and FEMTONICS. Designed for complex behavior experiments, this system provides insights into the competition of cortical clusters during on-demand visual learning in immersive virtual reality. 🐭 Key features: ✔ 270° FOV full coverage ✔ 3D articulated positioners ✔ Binocular vision ✔ Open-source software Find more details on this revolutionary product: t.ly/mogT9 #VirtualReality #Moculus #MouseVirtualRealitySystem #Neuroscience #Research #BrainVisionCenter #ScientificInnovation

Capturing moments from 2 impressive conferences! Our colleagues rocked it!👏 Zsolt Mezriczky is still mingling at the International Neuroscience Conference in Pécs, until 6PM today. Catch him for your questions on two-photon imaging! @BVC2021 @4Specialists

Visit our booth at the International Neuroscience Conference in Pécs & connect with the Hungarian neuroscience community!😉 Catch Levente (@BVC2021) at the Poster Session I, P2.19, from 12:00 to 14:00, presenting on 𝘈𝘤𝘰𝘶𝘴𝘵𝘰 𝘝𝘰𝘭𝘵𝘢𝘨𝘦 𝘐𝘮𝘢𝘨𝘪𝘯𝘨. @4Specialists

Always on the move at #SfN2023 #2635! Ongoing booth talks on in vivo 3D motion correction and on SmartX two-photon microscopy! Upcoming poster talk of Zoltán Szadai from 1 PM at #MM10 - "Cortex-wide mechanism of reinforcement signaling via a cholinergic pathway." See you there 😉

Congrats to our colleagues for their new publication on GFP-chromophore-based chemosensors for zinc ions detection using 2P microscopy. These sensors offer high selectivity, easy synthesis, & impressive 2P capabilities. A valuable addition to the field! 📃t.ly/AdQ6Y

Huge congratulations to Katalin Karikó on winning the 2023 Nobel Prize in Physiology or Medicine, alongside Drew Weissman! Her groundbreaking work in mRNA-based medicine played a vital role in the development of COVID-19 vaccines. 👏 #NobelPrize #KarikoKatalin

👀 Don't miss out on the latest breakthroughs in biophotonics research! 📷 Join us on April 26th to see Balázs Chiovini, PhD present at the Optica Biophotonics Congress in Vancouver, Canada! 🇨🇦 Click for the details: bit.ly/3USyNAh #neuroscience #biophotonics

👏Congrats to our colleagues for presenting their research at @AmerChemSociety! Their 4 poster sessions covered topics from microscopy to cancer diagnostics, and we're proud of their hard work! An inspiring talk on our novel fluorophore was also given. More details to come!🤩🧪

☝️Borbála Kertész, @BVC2021 scientist is representing Femtonics at the Neuro-Vascular conference until 29 March. She's showcasing the FEMTOSmart Dual🔬and Femtonics accessories which will revolutionize the way you conduct your research. See our cutting-edge technology in action💪