@BalazsLab

Using engineered immunity and synthetic immunology to investigate the underlying mechanisms of antibody-mediated treatment and prevention of infectious disease.

 Cambridge, MA
balazslab.partners.org/
Joined January 2017
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Our latest manuscript just came out in @ImmunityCP describing over a decade of work in the lab studying HIV evolution and escape from HIV broadly neutralizing antibodies. authors.elsevier.com/a/1mgR9…
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HIV deciding whether to take the easy way, or the hard way around an antibody.

ALT HIV deciding whether to take the easy way, or the hard way around an antibody.

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Our results suggest that decreasing viral fitness may synergize with bNAbs when treating HIV infection. However,I want to stress that all of this work was done in humanized mice and in vitro, which may not entirely recapitulate results we might see in actual humans.
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For the curious few who may want the raw data and code, please see here: doi.org/10.5281/zenodo.18187… ncbi.nlm.nih.gov/bioproject/…
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“We believe this insight will be crucial for the development of future HIV therapies that employ combinations of antibodies that can exert orthogonal selective pressure on the virus." Read More: ragoninstitute.org/2026/02/b…
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Congratulations to Ragon faculty member Alex Balazs, PhD, on his promotion to Associate Professor of Medicine at Harvard Medical School! #RagonInstitute #Faculty #Immunology #HIVResearch #COVID19 #Harvard
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Proud to share our latest paper on SARS-CoV-2 vaccines and the variants that have emerged (and continue to emerge). Bottom line is the latest versions of the mRNA boosters are doing a pretty good job of keeping up with variants. cell.com/cell-reports-medici…

Ongoing evolution of SARS-CoV-2 drives escape from mRNA vaccine-induced humoral immunity

Roederer et al. examine how the SARS-CoV-2 virus evolves over time and how well updated vaccines protect against variants. Variants of the virus are becoming harder for vaccine-mediated humoral...

cell.com
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We are looking for postdocs interested in working on this project to engineer polyclonal vectored antibody delivery!
Ragon Institute@ragoninstitute28 May 2024
Ragon faculty member Alejandro Balazs, PhD, has been awarded a prestigious Avant-Garde Award for HIV and Substance Use Disorder Research from the National Institute on Drug Abuse (NIDA), part of the National Institutes of Health (NIH). #HIV #Research #NIDA #NIH #Award
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