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BliskaLab (@BliskaLab) profile picture

BliskaLab

@BliskaLab

A group of scientists studying how bacterial effectors interact with the host immune system, at the Geisel School of Medicine at Dartmouth

 Hanover, NH
geiselmed.dartmouth.edu/bliska/
Joined December 2013
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  • Following176
  • Followers206
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Photo by BliskaLab (@BliskaLab)Photo by BliskaLab (@BliskaLab)Photo by BliskaLab (@BliskaLab)Photo by BliskaLab (@BliskaLab)
🚨Thesis Seminar Alert! MCB @DartGRAD student Haleema Sadia Malik from the @BliskaLab @DMS_MicroImmuno will be presenting her thesis tomorrow (Thurs. April 18) at 9am in Chilcott Auditorium! 👩‍🔬🦠
Image from Dartmouth MCB Graduate Program (@MCBDartmouth)
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Our paper is out @eLife!! elifesciences.org/articles/8… Huge congrats to co-1st authors @DanielAkuma5 @RonitSchwartz99 @KAWodzanowski & thanks to co-senior authors @taabaman @SunnyShinLab & other collaborators for this amazing effort! For more info see thread: xitter.gq/BrodskyIgor/status/157…
Catalytic activity and autoprocessing of murine caspase-11 mediate noncanonical inflammasome...

Catalytic activity and autoprocessing of murine caspase-11 mediate noncanonical inflammasome...

Caspase-11 catalytic activity and autoprocessing play key roles upstream rather than downstream of its assembly into higher-order inflammasome complexes in response to cytosolic bacterial lipopolys...

elifesciences.org
Igor Brodsky (@BrodskyIgor) profile pictureIgor Brodsky@BrodskyIgor23 Sep 2022
Excited to share our story on noncanonical inflammasome assembly biorxiv.org/content/10.1101/…. This is the fruition of a lot of hard work by outstanding @CAMBUpenn MSTP student @DanielAkuma5, collab w new friend/colleague @taabaman & long-term collaborator/partner @SunnyShinLab🥰🧵
Noncanonical inflammasome assembly requires caspase-11 catalytic activity and intra-molecular...

Noncanonical inflammasome assembly requires caspase-11 catalytic activity and intra-molecular...

Inflammatory caspases are cysteine protease zymogens whose activation following infection or cellular damage occurs within supramolecular organizing centers (SMOCs) known as inflammsasomes. Inflamm...

biorxiv.org
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BliskaLab retweeted
mBio (@mbiojournal) profile picture
mBio@mbiojournal16 Jan 2024
Evidence for Bacteroides (and the propionate it produces) as a probiotic in CF. @GeiselBiofilm @DartCF @BliskaLab #mBio journals.asm.org/doi/10.1128…
Image from mBio (@mbiojournal)
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Excite by our new paper in mBio lead by former student Courtney Price and current student Rebecca Valls with help from colleagues @DartCF. Proof of concept for probiotic use in CF and a role for propionate in the gut-lung axis. journals.asm.org/doi/10.1128… @m2p2_dartmouth
Image from George O'Toole (he/him/his) (@GeiselBiofilm)
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Very happy to share the culmination of a very fun 6+ year (!) collaboration with @VN2Mteam investigating the T6SS membrane complex of Bacteroidota. Thanks to all co-authors @epcrocha nature.com/articles/s41467-0…
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Thrilled to share the latest paper @mbiojournal from our & @BrodskyIgor’s labs on how Yersinia deploys T3SS effectors to evade the caspase-4 inflammsome in human IECs & macrophages! Congrats to 1st author @CAMBUpenn MD/PhD student @JennaJZhang!🧵1/n journals.asm.org/doi/10.1128…
Yersinia deploys type III-secreted effectors to evade caspase-4 inflammasome activation in human...

Yersinia deploys type III-secreted effectors to evade caspase-4 inflammasome activation in human...

Yersinia are responsible for significant disease burden in humans, ranging from recurrent disease outbreaks (yersiniosis) to pandemics (Yersinia pestis plague). Together with rising antibiotic...

journals.asm.org
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Pls RT: Open postdoc position with @AlanRHauser1 Lab (Northwestern U, Chicago) studying pathogenesis/antibiotic resistance of Pseudomonas and Klebsiella. How do these nasty bugs cause infections and resist treatment? See labs.feinberg.northwestern.e… to apply.
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BliskaLab retweeted
ASM (@ASMicrobiology) profile picture
ASM
@ASMicrobiology18 May 2023
Make a difference in an outstanding microbiologist's career & submit a nomination for #ASMAwards! From early career to lifetime achievement, clinical to environmental microbiology, ASM honors exceptional contributions at all career levels & in all fields. asm.social/1dj
2024 ASM awards and prize. Recognizing excellence in the microbial sciences. Nominate today.

ALT 2024 ASM awards and prize. Recognizing excellence in the microbial sciences. Nominate today.

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*Very* excited to share our latest paper in which we use metagenomics to understand how microbiome development during early life is altered in infants with cystic fibrosis. Led by @pesalerno and @ajverster biorxiv.org/content/10.1101/… @MCBDartmouth @m2p2_dartmouth @DartCF
Image from Benjamin Ross (@rossbenjamind)
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Co-first authors xitter.gq/buitengebieden/status/…
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When you join a lab that has only one research project. @PhDVoice
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We’re hiring! Searching for postdocs to develop some really exciting, newly-funded Yersinia projects exploring antibiotic persistence mechanisms. Previous experience with mouse models of infection, bacterial genetics, or immunology needed. Contact us for more info, pls retweet!
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Micro & Immuno at Dartmouth is hiring. Join a great crew of microbiologists in a supportive and engaging environment. Learn about our science/environment here: geiselmed.dartmouth.edu/micr…. Apply here: apply.interfolio.com/106872 @DartCF @ASMicrobiology Pls share!!
Image from George O'Toole (he/him/his) (@GeiselBiofilm)
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Data are available upon request : xitter.gq/PloederlM/status/15456…
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Trying to combine research with teaching
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I am excited to share our latest publication showing that inflammatory monocytes promote granuloma-mediated control of persistent Salmonella infection. Many thanks to ⁦@JulsBettke⁩, Jason Tam, ⁦@MontoyaVale8⁩, and Brian Butler! Please RT. journals.asm.org/doi/10.1128…
Inflammatory Monocytes Promote Granuloma-Mediated Control of Persistent Salmonella Infection |...

Inflammatory Monocytes Promote Granuloma-Mediated Control of Persistent Salmonella Infection |...

Persistent infections generally involve a complex balance between protective immunity and immunopathology. We used a murine model to investigate the role of inflammatory monocytes in immunity and...

journals.asm.org
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How your cell culture got contaminated during the weekend xitter.gq/theworldofdog/status/1…
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Very cool article on the history of discoveries of autoinflammatory diseases including FMF and CAPS: This genetic sleuth has uncovered a new category of disease marked by sporadic fevers and inflammation science.org/content/article/…
This genetic sleuth has uncovered a new category of disease marked by sporadic fevers and inflamm...

This genetic sleuth has uncovered a new category of disease marked by sporadic fevers and inflamm...

Daniel Kastner and colleagues have identified more than a dozen genes causing autoinflammatory diseases and helped find treatments for the conditions

science.org
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How FACS feels like xitter.gq/buitengebieden_/status…
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Shigella flexneri IpaH7.8 ubiquitinates and targets Gasdermin B for proteasome degradation, protecting Shigella from the bacteriocidic activity of natural killer cells by suppressing granzyme-A-mediated activation of GSDMB.  cell.com/cell/fulltext/S0092…
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