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As we age, our cells accumulate somatic mutations, a feature of aging that touches everyone. At @artan_bio we're building therapies + cosmetics to address it. Today we announced a $1M seed, and I'm stepping in as CEO. Advancing toward NHP studies now. prnewswire.com/news-releases…
Brian Bodemann retweeted
No success so far in using fusion to turn mercury into Bitcoin, thankfully.
Last month, we demonstrated high-rate alchemy: turning mercury into real, stable gold, beating CERN’s record by a factor of 10.
Last week, we enriched isotopes in the world’s most powerful plasma centrifuge, beating the Soviet record that stood for 40 years.
Now, we’re building a fusion reactor in San Francisco to achieve record power density.
Waving goodbye 👋 to offshore dollar creation….
The GENIUS Act marks a watershed moment in American finance, further cementing the United States as the crypto capital of the world. Just as President Abraham Lincoln’s National Currency Act of 1863 established a national framework for bank-issued currency, the GENIUS Act establishes a federal framework for payment stablecoins in the digital age.
The @USOCC's final rule carries that landmark legislation forward, providing a clear, practical foundation for private-sector innovation, competition, and American leadership in digital assets.
🚨But nic missed an important point, the supermajority legislature can change the eligibility line on the tax. Say hello to the mid-millionaire tax.
California politics of the last decade specialized in first order thinking and second order decline. 🥇 for meaning well.
this California wealth tax thing is just incredible.
so in October 2025, a California healthcare union proposed a "one time" 5% tax on any billionaire's wealth. the ballot measure will be voted on next month. In early December 2025, California announced that it would be a retroactive tax if passed, applying to anyone with CA residency as of Jan 1, 2026. The objective is to pay for Medi-Cal, California's incredibly dysfunctional healthcare system. (which also functions as a glorified welfare apparatus, but that's a discussion for another time).
polls reveal that the CA electorate is split around 50/50 on the tax, but prediction markets only give Prop 40 a ~23% chance of passing (there are competing measures on the ballet that would nullify it).
there are 200 billionaires in CA, worth collectively somewhere between $2.3 and $2.6 trillion. 5% of that is around $100b, accounting for a small amount of attrition. proponents of the tax forecasted a significant windfall, assuming only a 10% departure rate.
supporters thought they were being clever with the retroactive concept. no billionares would leave CA in the few short months between the tax being proposed and the residency cutoff date, without the tax even having passed yet, right?
well as it turns out, they did.
a new paper [1] from two academics at Stanford called "The Net Present Value of the California Billionaire Tax Act", argues that not only did more billionaires leave due to the proposed tax than its proponents expected, but that the value of the tax, if it does pass, is actually negative.
proponents of the tax only assumed 10% avoidance, that is, only 10% of the taxable base of targeted billionaires would leave CA within the very short Oct-Dec 2025 window. Jaros and Rauh, the Stanford academics, find that a lower bound of 28.6% of the taxable base managed to leave.
just based on known departures, those departures total $577b in net worth, or $28.8b in potential tax lost. this of course does not capture everyone (many left without announcing their departure), so the authors normalize to departure rates estimated from other wealth tax events, and apply other discounts for litigation, arriving arrive at a figure of only $28-$36b in forecasted tax revenues.
but this isn't all! all of the income taxes paid by the departed billionaires are also forsaken. the authors estimate that CA billionaires pay $3.3- 5.8b in annual income taxes. they assume a midpoint of $2b lost in annual collections from departed billionaires. the net present value of that lost income stream is -$68.9 billion.
so when you add it all up you get:
+ $30b one-time tax windfall (estimated)
- $69b in present value of lost future income taxes
= - 38.9b overall net present value of the tax
of course, this analysis is highly estimate driven. the authors simulate the parameters 100k times and find a negative NPV of the implemented tax 85 percent of the time.
and if the tax doesn't pass, which it's not looking like it will, California still ended up losing at least $577b in departed net worth, and they have permanently poisoned the well with entrepreneurs who will now worry about future wealth taxes.
[1]: nber.org/system/files/workin…
Brian Bodemann retweeted
Excited to receive this award! Hope to see some friends attend! Let’s keep building!
Brian Bodemann retweeted
Looking forward to representing @artan_bio at the @spARKbyARK Innovation Showcase here in St Pete. ARTAN, with the help of @vitarnabio $vitarna token holders is going after unique biology that addresses all 12 Hallmarks of Aging versus the more singular approaches of others!
X mobile 🔥
We announced an agreement to acquire a nationwide low-band spectrum license portfolio that will pave the way for @Starlink to become a major mobile carrier in the US.
With this new spectrum and our Gen2 constellation, Starlink Mobile can ensure Americans have access to high-speed mobile broadband no matter where they are → spacex.com/updates#starlink-…
Remember when open-source clones of popular apps were basically crap? Oh dear, thanks Adobe, It was a good run. I am here for the AI-coded rust-ification of great software. I wouldn't hold too tight to those $ADBE shares.
getartcraft.com/apps/vectorc…
Brian Bodemann retweeted
Arginine…
Can a single transfer RNA drive prostate cancer treatment resistance?
A new @Nature study found that loss of one tRNA, tRNA1-Arg(UCU), pushes prostate cancer cells toward a neuroendocrine-like state and makes them resistant to androgen receptor-targeted therapies. Restoring it reversed this shift and restored drug sensitivity in experimental models.
The mechanism involves SMARCC2, a SWI/SNF subunit important for maintaining AR signaling. Its mRNA is enriched in codons decoded by this tRNA, so when tRNA levels fall, SMARCC2 protein levels also decline.
In patient samples, low tRNA levels were associated with earlier metastasis and shorter survival.
No therapeutic delivery yet, but a striking link between codon biology, cancer cell identity, and treatment resistance.
Brian Bodemann retweeted
See y’all next week in Orlando! #twitter instagr.am/p/DePAQ3xK5hm/
Brian Bodemann retweeted
The cities of San Diego, Las Vegas, and Salt Lake City are all in the cone of Pacific Hurricane Rachel tonight.
Brian Bodemann retweeted
Fam, we building in St Pete, Florida with @spARKbyARK @ARKInvest. Time to put them gains to work @CathieDWood!
It sure looks like Lilly is about to get into the aesthetics business, based on this job listing spotted by @ky_lahucik
Hunting for assets in "cutaneous biology, body contouring, skin aging, hair biology, and adjacent aesthetic indications"
endpoints.news/lilly-signals…
Brian Bodemann retweeted
Interesting talk from @ARTAN_bio!
I was totally unfamiliar with stop codon emergence and possible Tx applications. Bold approach to an under-appreciated problem!
Packed house for the @ARTAN_bio talk tonight @ARDD_Meeting . I assume everyone wants to learn about Longevity Codon Therapy, $VITARNA, and fundraising on @BioProtocol with @vita_dao
























