We are yeast and fly enthusiasts interested in different aspects of cellular aging and organellar connectivity. Account run by lab members.
Stockholm, Sweden
Joined January 2021
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- Following800
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BüttnerLab retweeted
1/ Thrilled to share our new paper in @Nature: “CLCC1 promotes hepatic neutral lipid flux and nuclear pore complex assembly.” From our lab together with @apsarruda, led by co–first authors @alymathiowetz and @EmilyMeymand. 🥳
nature.com/articles/s41586-0…
BüttnerLab retweeted
With so many great reviews on LDs already out, do we need another?
Sarah @cohenlaboratory & I were approached by @NatRevMCB to organize a review on LD heterogeneity and inter-organelle contacts...topics often in reviews, but not a focus. Fun project!
nature.com/articles/s41580-0…
BüttnerLab retweeted
TDP43 aggregation at ER-exit sites impairs ER-to-Golgi transport
nature.com/articles/s41467-0…
BüttnerLab retweeted
Evolutionary origins of the lysosome-related organelle sorting machinery reveal ancient homology in post-endosome trafficking pathways | PNAS pnas.org/doi/10.1073/pnas.24…
BüttnerLab retweeted
So happy to finally see this out! Great work by first authors @A_STEDhammer and @petiaadarska which have shown that cargo flow along post-Golgi routes is driven by a key maturation step where compartments defined by ARF1 nature into recycling endosomes nature.com/articles/s41556-0…
BüttnerLab retweeted
Image summarizes the observations by Smith, Gay, and Babst @UofUBiology proposing a new function for the tricalbins: mediating the fusion of the ER to the plasma membrane at contact sites. hubs.la/Q02QBxc40
#Membrane #lipid #Trafficking #Biochemistry #ER_literature
BüttnerLab retweeted
In a special seminar on Monday, October 07, at 12:00, @Sfb1348 will host Sabrina Büttner @ButtnerLab, who just joined @uni_muenster. Welcome to our scientific community! Don't miss Sabrina's seminar on
Organelle connectivity during cellular aging and metabolic adaptation!
BüttnerLab retweeted
An exciting story from the lab! The balance of ceramide-glycerolipid synthesis in the ER regulates Caveolin1 localization. This is dependent on seipin, organizing #lipiddroplet formation.
#Golgi #Caveolin1 #ER_literature #Diatetes #Metabolicdisorders biorxiv.org/content/10.1101/…
BüttnerLab retweeted
Our new paper: Misfolded proteins activate HSF1 by releasing it from Hsp70. This has been clear in yeast for some time and we find that the mechanism is similar in human cells. sciencedirect.com/science/ar…
BüttnerLab retweeted
Wilson, @Adam_L_Hughes et al. observe that mitochondrial-derived compartments selectively incorporate proteins from only the outer mitochondrial membrane (OMM) and robustly sequester both excess and mistargeted proteins into this OMM-enriched domain. hubs.la/Q02L7pSP0
BüttnerLab retweeted
🥂Thrilled to see my latest #postdoc work out! What began as a quick, fun side project just before the first lockdown led me down a rabbit hole and ended in @NatureCellBio 4.5y later:
nature.com/articles/s41556-0…
#autophagy #polyamines #fasting #caloricrestriction🧵1/11
BüttnerLab retweeted
Posor & Haucke discuss the recent study by @JasonCasler, @LLLackner et al. @LacknerLabNU (hubs.ly/Q02JyKd30) describing how tripartite membrane contacts btwn #mitochondria, ER & plasma membrane regulate mitochondrial division & PI(4)P metabolism. hubs.ly/Q02JyTBm0
BüttnerLab retweeted
#MembraneContactSite community: Do not miss July 23, the earlybird registration deadline for our “Membrane Contact Sites in Cellular Homeostasis” @BiochemSoc meeting in Edinburgh. Submit an abstract by then for being considered for a short talk! bit.ly/Membrane24
BüttnerLab retweeted
Great to see our preprint out. We uncovered a simple likely mechanism to fuse inner+outer nuclear envelopes to precede nuclear pore complex (NPC) insertion.
Our first step was to show that CLCC1 is the long-lost human homologue of Brl1 (previously only known in yeast, protists)
New preprint w/ @apsarruda! Tour de force from grad student extraordinaire @alymathiowetz! >20 CRISPR screens enabled the discovery of a key role for CLCC1 in hepatic neutral lipid flux and nuclear pore complex assembly. Many surprises! #LipidDroplets 1/3 biorxiv.org/content/10.1101/…
BüttnerLab retweeted
Finally out! Unsaturated lipids regulate the growth of the apoptotic pore 🍩 @ShashankDadsena @CECAD_ link.springer.com/10.1038/s4…
BüttnerLab retweeted
We are proud and excited to share the new study from our lab, led by the amazing @RanenAviner. It uncovers an important pathogenic mechanism causing cellular dysfunction in Huntington's Disease. We hope this work will inspire new and effective therapies
nature.com/articles/s41556-0…
BüttnerLab retweeted
A breakthrough from the lab! A game-changer and the dawn of a new era in membrane and organelle biophysics and biology. We've generated giant organelle vesicles #GOVs with conserved biochemical activity. @AgenceRecherche @LP_ENS_ @ENS_ULM @NatureComms
nature.com/articles/s41467-0…
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BüttnerLab retweeted
Attention #LipidDroplet community. @MariaBohnert, Robin Klemm and I are thrilled to announce that the second edition of the #EMBOlipidDroplets workshop will take place September 21-26, 2025, again at beautiful Costa Brava. Mark your calendars already!
BüttnerLab retweeted
📢NEW #Preprint, Brainchild of @J_ATPase with Alessia, Peng & our amazing collaborators. Topics covered #ATG8ylation, #cell_wall_damage, #vacuolar_quality_control, #mechanostasis. biorxiv.org/content/10.1101/… Intrigued? See the 🧵for a summary:
BüttnerLab retweeted
Happy to share the preprint of my second postdoc project from the Schuldiner lab where we explored mitochondrial matrix proteome with a unique mtDNA-encoded reporter developed by Roza Kucharczyk and Hubert Becker. biorxiv.org/content/10.1101/…
