Greek/British| Developmental Biology PhD Student @MZG_Lab @Cambridge_Uni @CTR_Cambridge | @UniofNottingham alumna
Joined April 2013
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Charlotte Handford retweeted
Postdoc position available in @Vicensella lab (Spain)
Project:Endometrial and Trophoblast organoids to better understand feto-maternal crosstalk
Valencia: 🌞 🥘 🏖️
Link:fundanet.cipf.es/Convocatori…
Two days left to apply for it! Please RT
@SRF_Repro @IFPA_Official @CTR_Cambridge – at Madrid, Spain
Charlotte Handford retweeted
Tired of battling with noisy single-cell datasets? spinDrop to the rescue! We implement a sensitive droplet microfluidic system that discards empty droplets, cell multiplets and damaged cells from the sequenced dataset using droplet sorting. A 🧵(1/11) biorxiv.org/content/10.1101/…
Charlotte Handford retweeted
Our work on the self organization principles of stem cell derived embryos is finally published in Nature Cell Biology @NatureCellBio, special thanks to my supervisor @ZernickaGoetz, and wonderful collaborators @jake_cs_, Matt Thomson, @JoachimDeJonghe
rdcu.be/cVvDl
Charlotte Handford retweeted
Mouse embryos grown without eggs or sperm: why and what’s next? go.nature.com/3wuFQEr
Charlotte Handford retweeted
Congratulations to all these wonderful people with whom this very long journey was most special @GianlucaAmadei1 @CEHandford @JShendure @hollfelderlab @JoachimDeJonghe @ElowitzLab @CXchengxiangQIU @tranmartink @d_y_chen @Cambridge_Uni @Caltech and more ..
Our paper is finally out! After 10 years of model building we generate complete embryoids from three types of stem cells - they develop heart, brain structures and more. We show the first proof of concept knocking out a gene required for neurodevelopment nature.com/articles/s41586-0…
Charlotte Handford retweeted
Our paper is finally out! After 10 years of model building we generate complete embryoids from three types of stem cells - they develop heart, brain structures and more. We show the first proof of concept knocking out a gene required for neurodevelopment nature.com/articles/s41586-0… – at Los Angeles, CA
Charlotte Handford retweeted
A tour de force in synthetic embryology. Truly mesmerising pieces of work! Was extremely lucky to witness the development and execution of this project over years in the skilful hands of @GianlucaAmadei1 @CEHandford Kasey and collaborations of @MZG_Lab. Congrats all 👏🏽
After building embryoids for 10 years, we succeeded in generating structures with brains, hearts, neural tubes, somites with a yolk sac. Both original submissions using two different approaches are on BioRxiv, to be published soon. eur03.safelinks.protection.o…
Charlotte Handford retweeted
Congratulations @ZernickaGoetz @GianlucaAmadei1 @CEHandford and everyone else in the team!!!! It’s amazing to see how these embryo-like structures have improved throughout the years. This new achievement is just wow!!
After building embryoids for 10 years, we succeeded in generating structures with brains, hearts, neural tubes, somites with a yolk sac. Both original submissions using two different approaches are on BioRxiv, to be published soon. eur03.safelinks.protection.o…
Charlotte Handford retweeted
@GianlucaAmadei1, @CEHandford @ZernickaGoetz and collaborators with the lab put forth amazing effort to expand Gian's 2018 work over the past few years! These advanced cultured embryoids incredible. The first time Char called me over to see the heart beating I almost fell over!!
Stem cell-derived mouse embryos develop within an extra-embryonic yolk sac to form anterior brain regions and a beating heart biorxiv.org/cgi/content/shor… #bioRxiv
Charlotte Handford retweeted
.I also remember the first time Kasey's ESC-only derived embryoids were successful in 2020! You all were over the moon. Such a joy to have you as friends and colleagues ❤️
biorxiv.org/content/10.1101/…
Charlotte Handford retweeted
Excited to see the new gastrulating ETiX system as an extension of @GianlucaAmadei1's induceable model on biorxiv today, where early stages of organogenesis are recapitulated in vitro. Special thanks to @ZernickaGoetz @CEHandford and @GianlucaAmadei1 for the collaboration.
After building embryoids for 10 years, we succeeded in generating structures with brains, hearts, neural tubes, somites with a yolk sac. Both original submissions using two different approaches are on BioRxiv, to be published soon. eur03.safelinks.protection.o…
Charlotte Handford retweeted
Thanks to my most amazing lab @MZG_Lab and remarkable collaborators
ALT Brain
ALT Heart
ALT Primordial germ cells
Charlotte Handford retweeted
After building embryoids for 10 years, we succeeded in generating structures with brains, hearts, neural tubes, somites with a yolk sac. Both original submissions using two different approaches are on BioRxiv, to be published soon. eur03.safelinks.protection.o…
Charlotte Handford retweeted
New paper from the lab!
We developed a novel human organoid that periodically forms somite-like structures. The spheroid of human iPS cells elongates and starts forming pairs of somites according to the segmentation clock.
nature.com/articles/s41467-0…
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Charlotte Handford retweeted
Hot of the new home-built macroscope. 3 minutes of retinal waves imaged over entire retina. (5x speed). Scope designed and built by incomparable Ben Smith, biology provided by @atiriac1 and @MiahPitcher. So much more to come!
Charlotte Handford retweeted
Very happy to share with you our latest publication: elifesciences.org/articles/6… We have generated human yolk sac-like cells, and use them to model the yolk sac-epiblast interaction in vitro
Charlotte Handford retweeted
Extended culture of mouse embryos in vitro until day 11! Massive congratulations @jacob_hanna 👏👏👏 nature.com/articles/s41586-0…
Charlotte Handford retweeted
Everyone needs to see the birth of a baby octopus at least once in their life, right? xitter.gq/Oceandiversity2/status… – at Derby, England