@CTSPeng

Assistant Professor @ChemistryMIT, Core member @broadinstitute. Biophysics. Single molecule microscopy. Physical chemistry.

sampenglab.org
Joined January 2018
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Excited to share our work on ErbB receptors published today @CellCellPress! Using multicolor, photostable UCNPs, we perform long-term (>15 min) single-particle tracking of EGFR, HER2, and HER3, enabling direct visualization of dimerization in live cells. cell.com/cell/fulltext/S0092…
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Honored to receive the NIH Director’s New Innovator Award! Many thanks to my amazing group, collaborators, mentors, and @broadinstitute and @ChemistryMIT.
Broad Institute@broadinstituteOct 6
Congratulations to @yerinchen and @CTSPeng for receiving the @NIH Director’s New Innovator Award, and to JT Neal for his NIH Director’s Transformative Research Award. broad.io/HRHR2026
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Researchers in the Peng lab have recently revealed U-STORM—a revolutionary imaging tech using custom nanoparticles that blink indefinitely without fading, enabling sub-Ångström precision, marking a major leap for biological imaging. chemistry.mit.edu/chemistry-…
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Spontaneous and indefinite blinking in upconverting nanoparticles for ångström-precision multicolour super-resolution imaging Spontaneously blinking UCNPs enable single-source multicolor #superresolution imaging with 0.62 Å localization precision. nature.com/articles/s41565-0…
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Excited to share our work developing U-STORM super-resolution microscopy, now published @NatureNano! We engineered UCNPs that blink spontaneously and indefinitely, enabling two-color U-STORM imaging with sub-ångström localization precision using a simple optical setup without special imaging buffers. nature.com/articles/s41565-0…
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Congrats to the whole team lead by Saptarshi Mandal @sappy_superchem! @broadinstitute @ChemistryMIT Also thanks to the editor and reviewers for a thoughtful peer-review process.
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Here is a working version showing long-term blinking of UCNPs.
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Researchers in the Peng Lab use custom-built microscopy and nanotechnology to tag and follow the activity of individual proteins in real time. chemistry.mit.edu/chemistry-…
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Sam Peng retweeted
Cell@CellCellPressApr 29
Now online! ErbB family receptor dimerization dynamics and dysregulation via long-term single-molecule imaging dlvr.it/TSHgdQ

ErbB family receptor dimerization dynamics and dysregulation via long-term single-molecule imaging

Ma et al. developed long-term single-particle tracking of ErbB family receptors in living cells using upconverting nanoparticles. They discovered constitutive HER2 and HER3 homodimerization and...

cell.com
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Congratulations to Samuel Charney, Cole English, Julianna Lian, Alvin Meng, Kiarra Ning, and Abigail Strausbaugh Hjelmstad, who were all selected to receive 2026 @NSF Graduate Research Fellowships! chemistry.mit.edu/chemistry-…
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We also identified stable, ligand-independent heterodimers among all three receptors. These insights offer a comprehensive ErbB interaction network, elucidating diverse dimerization mechanisms and implications for oncogenic signaling.
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Congrats to the whole team co-lead by Kaibo, Xiaojie, and João! @broadinstitute @ChemistryMIT in collaboration with Matthew Meyerson, Heidi Greulich, Michael Eck! Thanks to the Johnsson lab for help with SNAP/CLIP tags, and the editor/reviewers for a thoughtful review process.
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