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CarboKeele (@CarboKeele) profile picture

CarboKeele

@CarboKeele

Glycoscience and carbohydrate research laboratories based at Keele University, UK.

 Keele
keele.ac.uk/glycoscienceresearch/
Joined January 2015
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  • Following317
  • Followers198
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Photo by CarboKeele (@CarboKeele)Photo by CarboKeele (@CarboKeele)
UK Proteoglycan Meeting 2024 @ Keele University - 15th January, 2024. Registration is free - come along, or join us online if you can. Please register interest here - forms.office.com/e/YXAGvBPp1… #glycotime #PGpeeps @2022Pg #Glycosaminoglycans @KeeleLifeSci
Image from CarboKeele (@CarboKeele)
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Latest output by @MycroftWest and colleagues on GAG-based, BACE-1 inhibition in Alzheimer's disease. #Alzheimers #Alzheimer #glycotime #Glycosaminoglycans @CarboKeele @KeeleUniversity @LivUni @KeeleLifeSci
CarbohydrateResearch (@CarbohydrateRes) profile pictureCarbohydrateResearch@CarbohydrateRes27 Jan 2023
A sulphated glycosaminoglycan extract from Placopecten magellanicus inhibits the Alzheimer's disease β-Site amyloid precursor protein cleaving enzyme 1 (BACE-1) dlvr.it/ShXMbC
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CarboKeele retweeted
Tim Rudd (@drtimmy78) profile picture
Tim Rudd@drtimmy7822 Sep 2022
'Evidence for multiple binding modes in the initial contact between SARS-CoV-2 spike S1 protein and cell surface glycans' doi.org/10.1002/chem.2022025… #RonzoniInstitute @CarboKeele @VitoFerro8 @dr_nehagandhi @DaveFernig @NIBSC_MHRA @ChemEurope
Evidence for Multiple Binding Modes in the Initial Contact Between SARS‐CoV‐2 Spike S1 Protein and...

Evidence for Multiple Binding Modes in the Initial Contact Between SARS‐CoV‐2 Spike S1 Protein and...

More than one way to get in: A hexasaccharide bound to site I of the spike protein in two binding modes (orange and green tubes) shows that multiple binding modes between heparan sulfate (HS) and S1...

chemistry-europe.onlinelibrary.wiley.com
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Latest press release from @KeeleUniversity @CarboKeele on #pixatimod: keele.ac.uk/about/news/2022/… #COVIDー19 #coronavirus #glycotime #COVID19 #COVID #COVID__19 #Covid19UK
Keele researchers discover a synthetic sugar to target Covid-19

Keele researchers discover a synthetic sugar to target Covid-19

An international team of researchers led by Keele University have discovered a potential new drug that could be used to reduce infection spread of Covid-19 and other emerging viruses.

keele.ac.uk
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CarboKeele retweeted
Tim Rudd (@drtimmy78) profile picture
Tim Rudd@drtimmy788 Jul 2022
Very happy to publish new research with colleagues from @CarboKeele (Drs Lima & Miller) and @LivUni (Dr Yates). pubs.acs.org/doi/10.1021/acs… #heparin #NMR – at Islington, London

Using NMR to Dissect the Chemical Space and O‑Sulfation Effects within the O- and S‑Glycoside...

Abstract. Heparan sulfate (HS), a sulfated linear carbohydrate that decorates the cell surface and extracellular matrix, is ubiquitously distributed throug

pubs.acs.org
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#ICYMI #glycotime Research by Jerry Turnbull & team @CarboKeele @LivUni Synthetic Heparan Sulfate Mimetic Pixatimod (PG545) Potently Inhibits SARS-CoV-2 by Disrupting the Spike–ACE2 Interaction go.acs.org/1fo
Image from ACS Central Science (@ACSCentSci)
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Our NEW issue is now live! Read it here: go.acs.org/1fn Cover story by Jerry Turnbull & team @CarboKeele @LivUni go.acs.org/1fm
Image from ACS Central Science (@ACSCentSci)
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PhD Studentship available in my lab. Plants Vs Mosquitos. 🌿v🦟 keele.ac.uk/study/postgradua… findaphd.com/phds/project/th…
Image from Thomas Torode (@TorodeTA)
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#mdpiMarineDrugs New Article 🗞️#Glycosaminoglycans from Litopenaeus vannamei Inhibit the #Alzheimer’s Disease β Secretase, BACE1 🔗mdpi.com/1660-3397/19/4/203
Image from Marine Drugs MDPI (@Marine_Drugs)
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Common anticoagulant drug targets coronavirus spike protein and could be repurposed for Covid-19 treatment keele.ac.uk/discover/news/20…
Common anticoagulant drug targets coronavirus spike protein and could be repurposed for Covid-19...

Common anticoagulant drug targets coronavirus spike protein and could be repurposed for Covid-19...

An international research team including Keele scientists has found that the common anticoagulant drug heparin inhibits the spike protein of the coronavirus, reducing the virus’ ability to attach to...

keele.ac.uk
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CarboKeele retweeted
Molly (@Mollydotpither) profile picture
Molly@Mollydotpither14 Oct 2020
My first author publication! On characterisation of the Lipid A from the chronic strain of the cystic fibrosis pathogen: Pandoraea pulmonicola. Huge thanks to the great team I work within @di_flaviana @MolinaroTony @AlbaSilipo @sweetcrosstalk #glycotime link.springer.com/article/10…
A chronic strain of the cystic fibrosis pathogen Pandoraea pulmonicola expresses a heterogenous...

A chronic strain of the cystic fibrosis pathogen Pandoraea pulmonicola expresses a heterogenous...

Glycoconjugate Journal - Pandoraea sp. is an emerging Gram-negative pathogen in cystic fibrosis causing severe and persistent inflammation and damage of the lungs. The molecular mechanisms...

link.springer.com
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Pixatimod (PG545), a clinical-stage heparan sulfate mimetic, is a potent inhibitor of the SARS-CoV-2 virus biorxiv.org/content/10.1101/… @CarboKeele #COVIDー19 #coronavirus #glycotime #COVID19 #COVID #COVID__19 #Covid19UK
Pixatimod (PG545), a clinical-stage heparan sulfate mimetic, is a potent inhibitor of the SARS-Co...

Pixatimod (PG545), a clinical-stage heparan sulfate mimetic, is a potent inhibitor of the SARS-Co...

A major global effort is currently ongoing to search for therapeutics and vaccines to treat or prevent infection by the SARS-CoV-2 virus. Repurposing existing entities is one attractive approach. The...

biorxiv.org
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We have an exciting 3-yr PDRA position available in the group: oligosaccharide synthesis & chemoenzymatic modification strategies. See advert below and pls RT or message me if interested. jobs.ac.uk/job/CAC843/resear…
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BBC News @RgalpinBBC article this morning raises awareness of thrombotic issues and anticoagulants. A third of patients have clotting issues. Time for heparin #coronavirus #COVID19 #COVIDー19 #COVID #glycotime @KeeleUniversity @LivUniISMIB bbc.co.uk/news/health-526620…

Coronavirus: A third of hospital patients develop dangerous blood clots

The virus appears to be making people's blood much more sticky, medical experts say.

bbc.co.uk
CarboKeele (@CarboKeele) profile pictureCarboKeele@CarboKeele4 May 2020
CHARTER trial protocol for nebulised heparin, as indicated by heparin's inhibition of SARS-CoV-2 biorxiv.org/content/10.1101/… is now out medrxiv.org/content/10.1101/… Now to get this trial off the ground around the world. #glycotime #COVIDー19 #coronavirus @KeeleUniversity @LivUniISMIB
Heparin inhibits cellular invasion by SARS-CoV-2: structural dependence of the interaction of the...

Heparin inhibits cellular invasion by SARS-CoV-2: structural dependence of the interaction of the...

The dependence of the host on the interaction of hundreds of extracellular proteins with the cell surface glycosaminoglycan heparan sulphate (HS) for the regulation of homeostasis is exploited by...

biorxiv.org
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Heparin inhibits coronavirus invasion at concentrations within the therapeutic range. Manuscript updated - now includes a dose response for live virus assays. #COVID19 #glycotime #coronavirus #COVID #Covid_19 @KeeleUniversity @KeeleLifeSci
CarboKeele (@CarboKeele) profile pictureCarboKeele@CarboKeele29 Apr 2020
COVID-19: The pharmaceutical heparin inhibits invasion of SARS-CoV-S2 in live viral assays. #COVID19 #coronavirus #glycotime @KeeleUniversity @KeeleLifeSci @Glycobiology @GlycobiologyUK biorxiv.org/content/10.1101/…
Heparin inhibits cellular invasion by SARS-CoV-2: structural dependence of the interaction of the...

Heparin inhibits cellular invasion by SARS-CoV-2: structural dependence of the interaction of the...

The dependence of the host on the interaction of hundreds of extracellular proteins with the cell surface glycosaminoglycan heparan sulphate (HS) for the regulation of homeostasis is exploited by...

biorxiv.org
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CHARTER trial protocol for nebulised heparin, as indicated by heparin's inhibition of SARS-CoV-2 biorxiv.org/content/10.1101/… is now out medrxiv.org/content/10.1101/… Now to get this trial off the ground around the world. #glycotime #COVIDー19 #coronavirus @KeeleUniversity @LivUniISMIB
Heparin inhibits cellular invasion by SARS-CoV-2: structural dependence of the interaction of the...

Heparin inhibits cellular invasion by SARS-CoV-2: structural dependence of the interaction of the...

The dependence of the host on the interaction of hundreds of extracellular proteins with the cell surface glycosaminoglycan heparan sulphate (HS) for the regulation of homeostasis is exploited by...

biorxiv.org
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Low Mw heparins also interact with the RBD... biorxiv.org/content/10.1101/… #glycotime #COVID19 #coronavirus @KeeleUniversity @KeeleLifeSci @Glycobiology @GlycobiologyUK
SARS-CoV-2 Spike S1 Receptor Binding Domain undergoes Conformational Change upon Interaction with...

SARS-CoV-2 Spike S1 Receptor Binding Domain undergoes Conformational Change upon Interaction with...

The dependence of the host on the interaction of hundreds of extracellular proteins with the cell surface glycosaminoglycan heparan sulphate (HS) for the regulation of homeostasis is exploited by...

biorxiv.org
CarboKeele (@CarboKeele) profile pictureCarboKeele@CarboKeele29 Apr 2020
COVID-19: The pharmaceutical heparin inhibits invasion of SARS-CoV-S2 in live viral assays. #COVID19 #coronavirus #glycotime @KeeleUniversity @KeeleLifeSci @Glycobiology @GlycobiologyUK biorxiv.org/content/10.1101/…
Heparin inhibits cellular invasion by SARS-CoV-2: structural dependence of the interaction of the...

Heparin inhibits cellular invasion by SARS-CoV-2: structural dependence of the interaction of the...

The dependence of the host on the interaction of hundreds of extracellular proteins with the cell surface glycosaminoglycan heparan sulphate (HS) for the regulation of homeostasis is exploited by...

biorxiv.org
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COVID-19: Latest preprint demonstrates the SARS-CoV-2 Spike RBD undergoes conformational change upon interaction with low molecular weight heparins. #glycotime #coronavirus #COVID19 @KeeleUniversity @KeeleLifeSci @GlycobiologyUK @glycopreprint @Glycobiology
bioRxiv (@biorxivpreprint) profile picturebioRxiv@biorxivpreprint30 Apr 2020
SARS-CoV-2 Spike S1 Receptor Binding Domain undergoes Conformational Change upon Interaction with Low Molecular Weight Heparins. biorxiv.org/cgi/content/shor… #bioRxiv
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Huge congratulations Gavin Miller @keelechem @KeeleUniversity on his outstanding success securing highly prestigious @UKRI_tweets Future Leaders Fellowship #UKRIFLF great success for Keele Chemistry Keele chemist awarded prestigious £1.2million fellowship keele.ac.uk/discover/news/20…

Keele chemist awarded prestigious £1.2million fellowship

A Keele scientist has received a £1.2million UK Research and Innovation (UKRI) Future Leaders Fellowship to develop a flagship program in carbohydrate chemical biology.

keele.ac.uk
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COVID-19: The pharmaceutical heparin inhibits invasion of SARS-CoV-S2 in live viral assays. #COVID19 #coronavirus #glycotime @KeeleUniversity @KeeleLifeSci @Glycobiology @GlycobiologyUK biorxiv.org/content/10.1101/…
Heparin inhibits cellular invasion by SARS-CoV-2: structural dependence of the interaction of the...

Heparin inhibits cellular invasion by SARS-CoV-2: structural dependence of the interaction of the...

The dependence of the host on the interaction of hundreds of extracellular proteins with the cell surface glycosaminoglycan heparan sulphate (HS) for the regulation of homeostasis is exploited by...

biorxiv.org
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