Cell Cycle & Signaling Lab @kocuniversity
Koç University, Istanbul
Joined August 2019
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Caydasi Lab - Cell Cycle & Signaling retweeted
Just published: Community Spirit: Plasmids for All
How a decade of plasmid-wrangling at @TheSainsburyLab grew into a movement — and the unexpected friends now helping us open the doors wider.
@Addgene @GetGenome @fullcirclelabs @NickDesnoyer @plasmidsaurus @genewizeu
medium.com/p/community-spiri…
Our new review chapter is out! We summarize current knowledge on PI(3,5)P₂, its regulation, emerging cellular functions, and links to human disease - while highlighting key tools and unanswered questions that will shape future research.
authors.elsevier.com/a/1nQIg…
#Phosphoinositides
Excited to share our collaborative paper! We show that the conserved yeast YPEL protein Moh1 links gene expression, metabolism, cell envelope remodeling, and selective stress resistance. Congrats to the team! @KocSciences @METU_ODTU #Yeast #OpenAccess
microbialcell.com/researchar…
Wonderful visit from Gabriel Neurohr from @ETH to our department this week! Great science and inspiring discussions with faculty and students! Thanks @GabrielNeurohr, for the fantastic @EMBO_YIP Lecture at @kocuniversity @KocSciences. Thanks to @EMBO_YIP for making this possible!
Gautam Dey (@Dey_Gautam, @embl) delivered a fantastic @EMBO_YIP Lecture today as part of the MBGE Seminar Series at @KocSciences @kocuniversity.
Thank you for the energy, enthusiasm, and inspiration you shared with us and our students!
Caydasi Lab - Cell Cycle & Signaling retweeted
Cargo adaptors use a handhold mechanism to engage with #myosin V for #organelle transport, say Hye Jee Hahn, Natalya Pashkova, Michael Cianfrocco, & Lois Weisman @umlifesciences
hubs.ly/Q03mXFwQ0
#Microbiology #Organelles #Trafficking
Caydasi Lab - Cell Cycle & Signaling retweeted
Excited to share our new preprint on @biorxivpreprint!
We show that USP28 mutations found in cancer block its interaction with 53BP1, disrupting p53 stabilization. Check out the full story...
biorxiv.org/content/10.1101/…
Caydasi Lab - Cell Cycle & Signaling retweeted
Preprint: IntAct-U-ExM enables robust, isoform-specific expansion microscopy of actin networks in yeast and mammalian cells. A cool study led by @anubhav_dhar in collab with @Sudiya14 @deepak_iisc #actin biorxiv.org/content/10.1101/…
Caydasi Lab - Cell Cycle & Signaling retweeted
Department of Molecular Biology and Genetics at the Koç University College of Sciences is hiring tenure-track faculty!
Grateful to Patricia M. Kane and @JCellBiol for highlighting our work.
Spotlight: Kane @UpstateNews discusses new work from @MaryHuda97 et al. @CaydasiLab (hubs.la/Q030lBmY0) showing that in S. cerevisiae transient cell cycle–dependent asymmetry in PI(3,5)P2 levels promotes vacuolar acidification in daughter cells. hubs.la/Q030lzJS0
Caydasi Lab - Cell Cycle & Signaling retweeted
Spotlight: Kane @UpstateNews discusses new work from @MaryHuda97 et al. @CaydasiLab (hubs.la/Q030lBmY0) showing that in S. cerevisiae transient cell cycle–dependent asymmetry in PI(3,5)P2 levels promotes vacuolar acidification in daughter cells. hubs.la/Q030lzJS0
Caydasi Lab - Cell Cycle & Signaling retweeted
🚨 Attention PhD students & postdocs! Last chance to apply for the FEBS Young Scientists’ Forum in Sapanca, Türkiye (2–5 July 2025). Present your research, network with peers, and learn from top scientists.
🗓 Apply by Dec 12, 23:59 (UTC+01:00). 2025.febscongress.org/ysf-ap…
#youngFEBS
Caydasi Lab - Cell Cycle & Signaling retweeted
How do organelles fit together inside a crowded cell? Answering this question requires a way to image many organelles in a whole cell at high resolution with high throughput. Our new preprint shows how to do this in yeast using soft x-ray tomography
biorxiv.org/content/10.1101/…
Caydasi Lab - Cell Cycle & Signaling retweeted
@MaryHuda97 et al. @CaydasiLab @kocuniversity show that asymmetric PI(3,5)P2 synthesis is crucial for vacuolar-pH asymmetry and provide insights into how the mother cell ages while the daughter cell is rejuvenated in budding yeast hubs.la/Q02Xx8N70
#Mitosis #CellSignaling
Job Alert! Our department, Department of Molecular Biology and Genetics at Koç University in Istanbul, has an open faculty position! Apply at academicjobsonline.org/ajo/j…
@kocuniversity @KocSciences
🚨Job Alert 🚨 @KocSciences Department of Molecular Biology and Genetics is hiring tenure track faculty. The call is broad and many different fields of biology will be considered. Join an incredible Department with great colleagues here in beautiful Istanbul!
I am excited to announce that our latest work is now published @JCellBiol! Huge congratulations to the co-authors @MaryHuda97 @KoyuncuMukadder @cansudilege. Big thanks to our funding bodies @Tubitak and @EMBO_YIP, @KocSciences, and to many labs who shared plasmid/strains with us.
@MaryHuda97 et al. @CaydasiLab @Kocuniversity reveal the dynamics of the vacuolar signaling lipid PI(3,5)P2 in budding yeast. PI(3,5)P2 synthesis is asymmetric during #mitosis and plays a key role in establishing vacuolar pH asymmetry. hubs.la/Q02Xx8N00
#Lipids
Employing a ratiometric in vivo vacuolar-pH sensor, we observed a pH drop in the daughter vacuole, while a pH increase in the mother vacuole, concomitant with changes in PI(3,5)P2 distribution during mitosis.