@CenikLab
 Austin, TX
ceniklab.github.io/
Joined October 2019
  • Tweets155
  • Following196
  • Followers436
11Media
Replying to @arjunrajlab
Earlier this summer I came across this and recommended to a new student in the lab: courses.ibiology.org/catalog…

Planning Your Scientific Journey

Plan your science career with our FREE course on strategic planning, crafting research questions, and mentorship for students and postdocs.

sciencecommunicationlab.org
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We are happy to unveil our latest published work where we describe how the metabolic enzyme, Pyruvate Kinase (PKM), regulates global mRNA translation in human cells. Here's a short 🧵... academic.oup.com/nar/advance…

Pyruvate Kinase M (PKM) binds ribosomes in a poly-ADP ribosylation dependent manner to induce...

Abstract. In light of the numerous studies identifying post-transcriptional regulators on the surface of the endoplasmic reticulum (ER), we asked whether t

academic.oup.com
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Cenik Lab retweeted
Vokes_Lab@LabVokes18 Nov 2022
Our study showing that Hedgehog signaling is essential for maintaining the early foregut and larynx by preventing EMT was published: doi.org/10.7554/eLife.77055 @eLife. This was led by recent @UTexasILS graduate Janani Ramachandran with help from Hongkai Ji @jihk99 and @ZornLab.

Hedgehog regulation of epithelial cell state and morphogenesis in the larynx

HH signaling prevents precocious EMT and cell death to maintain epithelial cell states during early stages of larynx development.

elifesciences.org
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Congratulations to the 2022 @UT_iGEM team for winning the the Best Foundational Advance award at the iGEM Grand Jamboree! They were also a top 10 overall undergraduate team, finalists for Best Presentation and Best Part Collection, and awarded a Gold Medal. @ut_mbs @TexasScience
iGEM@iGEM28 Oct 2022
Replying to @iGEM
Congrats to the teams from Freiburg and Austin!
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Our 1st effort into dissecting the crosstalk between #autophagy & other vacuolar trafficking pathways, now out in @JCellBiol Thx to everyone involved!
GMI Vienna gmivienna.bsky.social@gmivienna19 Oct 2022
‼️ #JustPublished in @JCellBiol New work from the Dagdas Lab at GMI @PlantoPhagy sheds light on the mechanism of #autophagosome maturation in #plants 🌱🌿 Read more: ➡️ bit.ly/PlantAmphisome #autophagy #plantautophagy #plantorganelle #organelletrafficking #amphisome 1/3
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🌮BioTACOS tomorrow, Mon Oct 17, 2022 9:30 am- 🌮 "RiboBase: A comprehensive databse of ribosome profiling data" by Hakan Ozadam in @CenikLab Please join in!
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It was our pleasure to host @SarinayElif for a virtual seminar today. Thanks a lot Elif for showing us the wonders of C.elegans and sharing your most recent findings with us.
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The MEF boss himself, @LabVokes , demonstrates the secrets and arts of MEF derivation!
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AGBT Abstract: @CenikLab from @UTAustin discusses single cell quantification of ribosome occupancy in early mouse development at the 2022 @AGBT General Meeting in Orlando. #AGBT22
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Our latest work on HIV-1 translation: Extensive uORF translation from HIV-1 transcripts conditions DDX3 dependency for expression of main ORFs and elicits specific T cell immune responses in infected individuals biorxiv.org/content/10.1101/…

Extensive uORF translation from HIV-1 transcripts conditions DDX3 dependency for expression of main...

Human immunodeficiency virus type-1 (HIV-1) is a complex retrovirus which relies on alternative splicing, translational and post-translational mechanisms to produce more than 15 functional proteins...

biorxiv.org
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Cell autonomous and non-autonomous consequences of deviations in translation machinery on organism growth and the connecting signalling pathways dlvr.it/SPK6Cl

Cell autonomous and non-autonomous consequences of deviations in translation machinery on organism...

Translation machinery is responsible for the production of cellular proteins; thus, cells devote the majority of their resources to ribosome biogenesis and protein synthesis. Single-copy loss of...

pubmed.ncbi.nlm.nih.gov
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MBS Seminar tomorrow! Noon- Prof. Andrew Fire (Stanford) "Opportunistic RNAs and aquisitive genomes" @ut_mbs @TexasScience
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Pubmed: Viral and cellular translation during SARS-CoV-2 infection dlvr.it/SNjBHP

Viral and cellular translation during SARS-CoV-2 infection - PubMed

SARS-CoV-2 is a betacoronavirus that emerged in China in December 2019 and which is the causative agent of the Covid-19 pandemic. This enveloped virus contains a large positive-sense single-stranded...

pubmed.ncbi.nlm.nih.gov
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Congrats @CenikLab @SarinayElif for the @RNAJournal Prize🏆🧬 "Genes with 5′ terminal oligopyrimidine tracts preferentially escape global suppression of translation by the SARS-CoV-2 Nsp1 protein" rnajournal.cshlp.org/content…
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Congrats to Can Cenik (@CenikLab) and colleagues on winning the @RNAJournal Prize for a paper on SARS-CoV-2’s Nsp1 protein. rnajournal.cshlp.org/content… @ut_mbs
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We have a postdoc position open for someone who wants to work on ribosome assembly! For some of our recent work, check out our preprint biorxiv.org/content/10.1101/… by @jamie_yelland. Contact me at [email protected] if you're interested.

A single 2’-O-methylation of ribosomal RNA gates assembly of a functional ribosome

RNA modifications are widespread in biology, and particularly abundant in ribosomal RNA. However, the significance of these modifications is not well understood. We show that methylation of a single...

biorxiv.org
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Check out our new manuscript demonstrating that conserved uORFs regulate HOX mRNA translation. A fun collaboration with Tom Dever’s lab at the NIH. Spicier than Frank’s red HOX sauce 😉 pnas.org/doi/10.1073/pnas.21…

Evolutionarily conserved inhibitory uORFs sensitize Hox mRNA translation to start codon selection...

Translation start site selection in eukaryotes is influenced by context nucleotides flanking the AUG codon and by levels of the eukaryotic translat...

pnas.org
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Jamie's manuscript is now on BioRxiv. Check it out! A single 2'-O-methylation of ribosomal RNA gates assembly of a functional ribosome biorxiv.org/content/10.1101/…

A single 2’-O-methylation of ribosomal RNA gates assembly of a functional ribosome

RNA modifications are widespread in biology, and particularly abundant in ribosomal RNA. However, the significance of these modifications is not well understood. We show that methylation of a single...

biorxiv.org
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Cenik Lab retweeted
Vokes_Lab@LabVokes10 Feb 2022
Excited that our paper “GLI transcriptional repression is inert prior to Hedgehog pathway activation” led by @ut_mbs graduate Rachel Lex was just published @NatureComms. rdcu.be/cGKez. Our findings in the limb bud challenge current GLI pre-patterning models. #hedgehog
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Whah!?!? Actually sitting in a lecture hall listening to awesome work from ⁦@SarinayElif⁩ at the in person ⁦⁦@ut_mbs⁩ graduate student retreat! I’m in heaven!
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