@CharlieDowell4

Postdoctoral associate at The Rockefeller University: https://xitter.cf/t.co/NqXY7Yi70g PhD Neuroscience from UCL: https://xitter.cf/t.co/U0ysLflyLE

Joined May 2019
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I am delighted to share the main work from my PhD with @ibianco3. We used the saccadic eye movements of larval zebrafish to investigate fundamental mechanisms of motor control. biorxiv.org/content/10.1101/…

Subsets of extraocular motoneurons produce kinematically distinct saccades during hunting and...

Animals construct diverse behavioural repertoires by moving a limited number of body parts with varied kinematics and patterns of coordination. There is evidence that distinct movements can be...

biorxiv.org
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Charlie Dowell retweeted
ibianco@ibianco35 Nov 2024
🚨🚨🚨Calling aspiring group leaders! We've just opened a new round of applications for group leader fellowship sponsorship to start a lab in UCL NPP. Deadline 5 Jan #sciencejobs @uclnpp tinyurl.com/yfvsa8a7
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nature.com/articles/s41586-0…

Glucose-sensitive insulin with attenuation of hypoglycaemia

Nature - NNC2215 is an insulin conjugate that can reversibly adjust its bioactivity in response to a diabetes-relevant glucose range in vivo.

nature.com
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Charlie Dowell retweeted
David Rowland@DavidCRowland9 Oct 2024
One of my favorite papers of the year is out today! The Ruta group very elegantly show how modular neural circuits can enable rapid evolution of mate recognition. Cool time for evolution of circuits and behavior! nature.com/articles/s41586-0…

A modular circuit coordinates the diversification of courtship strategies

Nature - Peripheral and central circuit adaptations can be flexibly coordinated in Drosophila, and such a modular circuit organization may facilitate the evolution of mate recognition systems by...

nature.com
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Kinematically distinct saccades are used in a context-dependent manner by larval zebrafish: Current Biology cell.com/current-biology/ful…

Kinematically distinct saccades are used in a context-dependent manner by larval zebrafish

Dowell et al. characterize the repertoire of saccadic eye movements of larval zebrafish and examine their coordination with swims during visuomotor behaviors. Differences in timing, kinematics, and...

cell.com
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My work charactising the saccadic repertoire of larval zebrafish with @ibianco3 is now at @CurrentBiology: cell.com/current-biology/ful…

Kinematically distinct saccades are used in a context-dependent manner by larval zebrafish

Dowell et al. characterize the repertoire of saccadic eye movements of larval zebrafish and examine their coordination with swims during visuomotor behaviors. Differences in timing, kinematics, and...

cell.com
Charlie Dowell@CharlieDowell411 Nov 2023
I am very pleased to share the first preprint from my PhD. biorxiv.org/content/10.1101/…

The saccadic repertoire of larval zebrafish reveals kinematically distinct saccades that are used...

Saccades are rapid eye movements that are used by all species with good vision. They have been extensively studied, especially in vertebrates, and are understood to be controlled by a conserved...

biorxiv.org
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The type Y motoneurons by contrast overlapped topographically with motoneurons especially active for convergent saccades, receiving input from diverse sources on their Y shaped dendrites.
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Combined we identify a mechanism by which kinematically and ethologically distinct movements are made by the recruitment of different motoneuron subpopulations, in turn differentially controlled by parallel action-specific and generalist premotor pathways.
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Personally, this work has shown me the beauty and complexity of neural circuits underpinning even the simplest movements, making our day-to-day feats of boiling the kettle or scrolling Twitter seem all the more remarkable - let alone what Simone Biles can do.
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