Aiming to understand RNA regulation
Boston University
Joined March 2020
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Congratulations!! Well deserved and long due!
BREAKING NEWS
The 2024 #NobelPrize in Physiology or Medicine has been awarded to Victor Ambros and Gary Ruvkun for the discovery of microRNA and its role in post-transcriptional gene regulation.
Cifuentes Lab retweeted
Victor Ambros and Daniel Cifuentes have made clear the importance of research in model organisms, like C.elegans 🪱 or zebrafish 🐟, to understand human disease 👏👏
Cifuentes Lab retweeted
Davor Lessel briefing us on the progress on human Ago mutations. A lot has happened, but there’s still a lot to be done. We need both, brilliant minds and financial resources, to fully understand Ago syndromes and thereby help patients
Cifuentes Lab retweeted
Our new preprint is Biorxiv! CRISPR-RfxCas13d screening uncovers Bckdk as a post-translational regulator of the maternal-to-zygotic transition in teleosts @CABD_UPO_CSIC. Another fantastic collaboration with @BazziniLab @ScienceStowers. biorxiv.org/content/10.1101/… A thread(1/10):
Cifuentes Lab retweeted
Dr. @dmitrykretov1 led this research showing that miR-144 single-handedly regulates multiple chromatin factors to force #erythrocyte progenitors into the differentiation pathway.
Congratulations to everyone involved! 🎊 @CifuentesLab @DrGJMurphy
go.nature.com/3UzT9yM
Wondering how microRNAs can have mighty impacts on the transcriptome?
Here (rdcu.be/dHdub) we show how miR-144 effects expand beyond its direct targets by targeting a chromatin regulator during hematopoiesis. Congratulations, team!
Cifuentes Lab retweeted
Re: the history of the DNA structure, see this blistering 1967 letter from Crick to Watson objecting to the draft of Watson’s book on their work. “...it shows such a naive and egotistical view of the subject as to be scarcely credible.” profiles.nlm.nih.gov/spotlig…
Cifuentes Lab retweeted
I am excited to present this work led by Frederick Rehfeld (not on Twitter). We performed genome-wide CRISPR screens to identify host factors required for programmed ribosomal frameshifting by SARS-CoV-2. 1/4
cell.com/cell-reports/fullte…
Cifuentes Lab retweeted
@galloway_lab @NorthTrista and I are organizing a Boston Area ZebrAfish Researchers (BAZaR) meeting at Boston College on March 18! Please get the word out and let us know if you plan to come!
sites.google.com/bc.edu/baza…
Cifuentes Lab retweeted
More thoughts on the demise of disruptive science.
Take Fred Sanger, 2x Nobel Prize winner. Sydney Brenner wrote about him in an obituary that multiple times in Fred's career, he went 10+ years without publishing as he was working on 'disruptive' science.
science.org/doi/full/10.1126…
We are looking for an #RNA wizard to unlock the mysteries of RNA regulation by RNA-binding proteins in viral and vertebrate systems. If you are the One, apply for a postdoc position in the Cifuentes Lab! cifulab.com/
; rnasociety.org/postdoctoral-…
Cifuentes Lab retweeted
How do Dicer-1 and Loqs-PB make miRNA?
We captured 6 cryo-EM structures showing stages of pre-miRNA cleavage. Dicer•Loqs bend pre-miRNA to cleave the right targets:
cell.com/molecular-cell/full…
Fun collab. with @zamore_lab and Traci Hall (NIEHS). Congrats,@KarinaJouravl and Dima!
Not an NGG available in that target that you must edit? What about just NGN? Yes? Then check the latest pre-print from @crisprscan for new Cas9 variants with minimal PAM sequence requirements
biorxiv.org/content/10.1101/…
Wondering how to uncover the RNA-binding proteins bound specifically to the viral RNAs? Check the new work from the @castello_lab #SARS_CoV_2 sciencedirect.com/science/ar…
Cifuentes Lab retweeted
Congrats to Marlies Rossmann on our recent paper in Science. We found that mitochondrial metabolism and coenzyme Q synthesis directed by the cell-specific transcription factor TIF1g is required for blood cell development. science.sciencemag.org/conte…
Cifuentes Lab retweeted
Want to optimize or deoptimize gene expression in vertebrates? Check out our new tool: iCodon 😎
@BazziniLab @ScienceStowers @GSSIMR
iCodon: ideal codon design for customized gene expression biorxiv.org/cgi/content/shor… #bioRxiv
Cifuentes Lab retweeted
In zebrafish embryos, cytoplasmic streaming leads to the segregation of embryo from yolk granules. Credit to @HeisenbergCPLab. #ZebrafishZunday