ALT Understanding consciousness is one of the greatest challenges of neuroscience. Is it possible to develop brain-based measures of consciousness? Why does it fade and recover during transitions across brain states? Researchers at the Human Brain Project (HBP) are addressing this challenge by merging new clinical methods and advanced brain modelling on the EBRAINS research infrastructure. Over the past years, they used a novel approach to investigate brain activity in conscious and unconscious states from the micro-level to the whole brain. The live-stream will feature: Alain Destexhe, Research Director at CNRS and Director of the European Institute for Theoretical Neuroscience. Marcello Massimini, Professor in the Department of Biomedical and Clinical Sciences at the University of Milan. Steven Laureys, clinical neurologist and Research Director at FNRS and Director of the GIGA Consciousness Research Unit at the University Hospital of Liège. He will host the discussion.