Neuroscientist | Scientific Director #Neurodegeneration #Alzheimers #Dementia #Memory #Cognition #Behavior #Aging #RareDisorders #NeuroDevelopmental
New York | Stockholm
Joined June 2011
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Groundbreaking discovery, if accurate: Parkinson’s disease may begin either in the brain or in the intestines, which suggest two different subtypes. The discovery could explain the wide variety of symptoms and guide future treatments academic.oup.com/brain/advan…
Dan Famer, PhD retweeted
Older People Have Become Younger:
The #physical and cognitive health of people aged 75 to 80 is significantly better than those of that age range thirty years ago.
neurosciencenews.com/aging-c…
A matter of language! Bilingual vs monolingual:: developmental basis suggested for structural differences in adult brains
Bilingualism produces experience-dependent gray and white matter changes in brain structures of adults, study shows mentaldaily.com/article/2020… #bilingualism #science #neuroscience
Interesting article, for those who have full access to the journal #OpenAccessNow
'Dickens and Neurology'. Andrew Larner looks back 150 years at neurological signs and symptoms that featured in Dickens’ novels
bit.ly/3f3N9I7
Many elderly have symptoms of dementia w/o telltale signs. Recently recognized brain disorder mimics clinical features of #Alzheimers. @NIH recommended diagnostic criteria and guidelines: Limbic-predominant Age-related TDP-43 Encephalopathy (aka, LATE) nih.gov/news-events/news-rel…
Looking forward to further studies on the neuroanatomical structure of the semantic network @Brain1878
By studying patients with semantic dementia, Chen et al. refine the neuroanatomical structure of the semantic network and highlight the critical role of the left fusiform gyrus and its connections. bit.ly/2xuNl2z
While some interethnic differences are expected, the subsequently increased susceptibility to dementia-related brain changes and cognitive dysfunction may have significant implications
This paper looks relevant, about interethnic differences in cerebrovascular and neurodegenerative markers in Asian ethnicities. I haven't came across as many studies on Asian compared to non-Asian populations related to CVD and AD...
nature.com/articles/s41598-0…
Seeking treatment options is a noble cause, but the reality may be that early #prevention is the only viable option for #dementia and #Alzheimers disease
Dan Famer, PhD retweeted
Interesting pre-clinical evidence of age-related changes in protein homeostasis that may lead to⬆️susceptibility to peripheral α-Syn pathology and support the role of gut-brain axis in central neurodegeneration. Of relevance to a range of human synucleinopathies incl #Parkinsons.
More evidence for role of gut-brain axis in neurodegeneration. -Gut-seeded α-synuclein fibrils promote gut dysfunction and brain pathology specifically in aged mice | @NatureNeuro nature.com/articles/s41593-0…
During adult hippocampal neurogenesis, microglial phagocytosis of apoptotic cells may be the link btw proliferation of newborn cells and apoptosis, suggested to be necessary for learning and memory: mechanisms promoting regeneration in aging and neurodegenerative diseases
Microglia Actively Remodel Adult Hippocampal Neurogenesis through the Phagocytosis Secretome
jneurosci.org/lookup/DOI/10.…
There is compelling evidence suggesting #inflammation events behind many #neurodevelopmental and #neurodegenerative conditions. This is yet another find @Nature
#NeuroDevelopmental_Disorders & #Inflammation | IL-17a promotes sociability in mouse models | Gloria Choi @MIT @Nature buff.ly/36BB740 | #2020_Jan_ReCap
The p Factor: can one general #psychopathology factor influence psychiatric symptoms and unite all psychiatric disorders through their neurological roots? #OpenAccess #mentalhealth #mentalillness ncbi.nlm.nih.gov/pmc/article…
If validated in intact human brain, this discovery could be key in helping us understand our intelligence: "Newly identified dendritic action potentials give humans unique brain power" @aaas #brain #intelligence #dendrites eurekalert.org/pub_releases/…
Kicking off the new year on the right path: Our mouth normally hosts a diverse and relatively stable community of bacteria. Dental plaque under the gum can form inflamed pockets of P. gingivalis which release toxins associated w #Alzheimers disease newscientist.com/article/219…
Dan Famer, PhD retweeted
It’s the time of the year when families come together and show their appreciation for one another. Don’t forget the special #caregivers in your lives. #CaregiversMonth Retweet with a story of appreciation for a caregiver you know. #BeCareCurious
Dan Famer, PhD retweeted
This animation shows the ligand-gated ion channel GABA_A. GABA binds to the extracellular portion of the GABA_A receptor. This causes a conformational change of the GABA_A receptor which leads to the opening of the channel. Chloride ions (green) can then rush into the cell.
Intriguing
Story time! Single neurons in the brain can’t be depended on for reliable information. Here are some neurons from our recent study, recorded twice in response to the same visual stimuli. Different neurons are active at different times!
biorxiv.org/content/10.1101/…
For all of us that have never believed in the "amyloid hypothesis": New study demonstrate assoc btw P gingivalis bacteria (gum disease), neuroinflammation, amyloid production, Tau tangles, and neural damage normally seen in #Alzheimers disease #dementia advances.sciencemag.org/cont…
February 28 is #RareDiseaseDay. What can we do today to improve the Quality of Life for the patients and their families
Today is #RareDiseaseDay! We're proud to be a part of the #rare community and continue to support those living with rare disorders. Get involved! #ShowYourRare bit.ly/2DML0hE #ShowYourStripes
Today, we recognize Angelman Syndrome families, patients, and the whole rare disease community: #Angelmansyndrome a rare #neurodevelopmental disorder
Today is International Angelman Day, where the world comes together to raise awareness for #Angelmansyndrome. Find out more about the day here: bit.ly/2f632Ag