Dane J Dickson (@DaneJDicksonMD) profile picture

Dane J Dickson

@DaneJDicksonMD
Joined February 2018
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Photo by Dane J Dickson (@DaneJDicksonMD)Photo by Dane J Dickson (@DaneJDicksonMD)Photo by Dane J Dickson (@DaneJDicksonMD)Photo by Dane J Dickson (@DaneJDicksonMD)Photo by Dane J Dickson (@DaneJDicksonMD)Photo by Dane J Dickson (@DaneJDicksonMD)Photo by Dane J Dickson (@DaneJDicksonMD)Photo by Dane J Dickson (@DaneJDicksonMD)
In order for Dr Hahn’s vision to become a reality we need better real world data but not at the expense of the common rule and patient consent. Balance is needed to ensure patient protection and allow the advancements of science.
Vivek Subbiah, MD (@VivekSubbiah) profile pictureVivek Subbiah, MD
@VivekSubbiah31 Jan 2020
Dr. Steve Hahn Stresses Importance of Data, RWE in First All-Hands Meeting | RAPS ⁦@SteveFDA⁩ raps.org/news-and-articles/n…

News & Insights Search

raps.org
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Okay - have you ever seen this on PET scan? Metastatic appearing bright lesions like one to the left in many places - but this acetabellum looks periosteal only - still looking for malignancy source biopsy x 2 negative
Image from Dane J Dickson (@DaneJDicksonMD)
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Great article from Vivek Subbiah MD (@VivekSubbiah) at MD Anderson outlining a blueprint of where "The next generation of evidence-based medicine" will come from. Grateful for his highlighting our pre-competitive effort as part of this future. nature.com/articles/s41591-0…
The next generation of evidence-based medicine

The next generation of evidence-based medicine

Nature Medicine - Technological advances are transforming evidence generation in medicine; for these advances to impact public health, the clinical trial landscape must evolve and adapt to keep pace.

nature.com
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To demonstrate our commitment to improving healthcare outcomes for everyone, Taproot has become a public benefit corporation (PBC). A PBC is a unique type of corporation that balances the pursuit of a public good with fiduciary responsibility. #data #research #cure
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Agree
Bishal Gyawali, MD, PhD, FASCO (@oncology_bg) profile pictureBishal Gyawali, MD, PhD, FASCO
@oncology_bg21 Dec 2021
Don’t know who needs to hear this but NCCN guidelines are just guidelines- not mantra that you should religiously adhere to. You can read the underlying study by yourself. Not following the NCCN guidelines is not a sub-standard practice as long as it’s an informed decision.
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Molecular testing at the center of unlocking personalized cancer care is extremely complex. This is in the testing alone. What about the clinical outcome tied to molecular testing ? Can we ever unlock personalized oncology with tying testing to outcomes? nature.com/articles/s41587-0…
Toward best practice in cancer mutation detection with whole-genome and whole-exome sequencing

Toward best practice in cancer mutation detection with whole-genome and whole-exome sequencing

Nature Biotechnology - Recommendations are given on optimal read coverage and selection of calling algorithm to maximize the reproducibility of cancer mutation detection in whole-genome or...

nature.com
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"Detection of cancer mutations is an integrated process. No individual component can be singled out in isolation as more important than any other, and specific components affect and interact with each other.
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Every component and every combination of components can lead to false discovery (false positives or false negatives). Individual components of cancer mutation calling should never be considered 'plug and play'." Thank you FDA-CDRH for this work! Thank you Wenming Xioa et. al.
Way to go ABIM! “Spreading misinformation or falsehoods during a time of a public health emergency goes against everything our board certified physicians stand for. The evidence that we have safe, effective and widely available vaccines against COVID-19 is overwhelming.”
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Taproot Health is excited to welcome Renee Ubico as Clinical Site Manager. Renee has over a decade of experience in building relationships between medical providers, patients, and research teams. Click here to learn more: taprootco.com/our-team/ #leadership #data #research
Image from Taproot Health Inc (@taproot_health)
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Exciting news in #cancerresearcher A new light activated cancer drug could kill cancer without harming healthy tissues. This drug acts like a Trojan Horse, disguising itself as food and tricking malignant cells to consume it. #endcancer #oncology nature.com/articles/s41467-0…
Photoactivatable metabolic warheads enable precise and safe ablation of target cells in vivo

Photoactivatable metabolic warheads enable precise and safe ablation of target cells in vivo

Nature Communications - Metabolites can distinguish pathogenic from healthy cells, but they are hard to couple to current photosensitizers without altering their biological activity. Here the...

nature.com
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We need continuous data collection in oncology to iteratively improve care of all patients. Old treatments and diagnostic paradigms need to evolve. We need to work together as an oncology community to make this happen. linkedin.com/posts/dane-dick…
#regulatoryrequirements #rwd #rwe | Dane Dickson, M.D.

#regulatoryrequirements #rwd #rwe | Dane Dickson, M.D.

https://lnkd.in/gTDAGFJ This action highlights the need for continual evidence development in oncology. Treatments approved years ago may no longer have relevance due to newer and more targeted...

linkedin.com
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Very strong paper demonstrating why a pre-competitive national prospective oncology registry with standardized outcomes tied to granular molecular data is needed. Taproot's ROOT study was built to answer these questions. nature.com/articles/s41587-0…
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⭐️How do we address real world challenges of #precisionmedicine ? So relevant for @AACR #AACR21 discussion 👉The Master Observational Trial: A New Class of Master Protocol to Advance Precision Medicine @CellPressNews @DaneJDicksonMD @Dr_R_Kurzrock bit.ly/3adaGWS
Image from Vivek Subbiah, MD (@VivekSubbiah)
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#COVID19 has become a catalyst in the medical industry to improve the quality and efficiency of patient care and #ClinicalResearch. Many of these adaptions will be long lasting and positively shape emerging #clinicaltrials. #data #cancer #RWD onclive.com/view/covid-19-ha…
Image from Taproot Health Inc (@taproot_health)
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@taproot_health is spearheading the national observational trial ROOT to fill a gap in cancer research. Click here to learn more: taprootco.com/clinical-trial… #clinicaltrials #rwd #bigdata #cancer #research
Image from Taproot Health Inc (@taproot_health)
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Taproot is excited to announce that Guy Fordham will be joining our executive team as Senior Vice President of Finance. Click here to learn more about Guy: taprootco.com/our-team/ #Data #Cancer #finance #healthcare #BigData #rwd #technology #Leadership
Image from Taproot Health Inc (@taproot_health)
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Today heralds a pivot from a season of gratitude to a season of giving. To me, Intersecting both is gratitude for the quiet sacrifices of so many who have helped along the way. I am grateful for unspeakable gifts given selflessly and completely both seen and unseen. #givethanks
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Grateful for family that can see humor inspire of tough times. Son just sent this. Appreciate @EricTopol @Dr_R_Kurzrock @VivekSubbiah sharing news about family among scientific tweets. Important we keep each other safe mentally and physically.
Image from Dane J Dickson (@DaneJDicksonMD)
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Taproot Health is the only national oncology RWE initiative driven by a high-quality protocol, IRB approval and adheres to all compliance rules. Regulatory grade data requires regulatory grade methods! Find out how Taproot is leading the push in regulatory RWE in oncology! 2 of2
Real-World Evidence: A Reality Check managedhealthcareexecutive.c… "The use of RWE to make clinical assertions. . has a lot of room to grow. .it has to be done the right way, with a high-quality protocol, IRB approval and compliance with patient privacy rules." 1 of 2
Real-World Evidence: A Reality Check | Managed Healthcare Executive

Real-World Evidence: A Reality Check | Managed Healthcare Executive

Can data mined from EHRs match that from the gold standard, randomized clinical trials?

managedhealthcareexecutive.com
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