@DoerrLab

We study how bacteria build and maintain a healthy cell envelope and resist killing by antibiotics.

 Ithaca, NY
doerr.wicmb.cornell.edu/
Joined August 2017
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  • Following632
  • Followers1.6K
65Media
Thrilled to share the first paper of my PhD @DoerrLab is live at PLOS Pathogens! journals.plos.org/plospathog…

Prevalence and mechanisms of high-level carbapenem antibiotic tolerance in clinical isolates of...

Author summary Bacteria can survive exposure to antibiotics by constantly repairing cellular damage induced by the drug. This “antibiotic tolerance” enables diverse bacteria to survive long enough to...

journals.plos.org
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Baskin Lab researchers have uncovered the surprising role played by a “three-tailed” fat molecule in cellular survival during heart attack and stroke: protecting the cells against damage when oxygen runs out. news.cornell.edu/stories/202…

‘Three-tailed’ lipid helps cells survive during heart attack, stroke | Cornell Chronicle

Cornell researchers have uncovered the surprising role played by a “three-tailed” fat molecule in cellular survival during heart attack and stroke: protecting the cells against damage when oxygen...

news.cornell.edu
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Research led by @weillinstitute postdoctoral fellow Megan Keller in @DoerrLab reveals how sugar-phosphate buildup disrupts cell wall synthesis, offering clues to fight drug resistance. news.cornell.edu/stories/202…

Cornell biologists expose bacteria’s hidden Achilles’ heel | Cornell Chronicle

Helping to combat the rising threat of antibiotic resistance, Cornell biologists have identified a surprising mechanism that weakens bacteria from within—an insight that could guide the next genera...

news.cornell.edu
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We’re thrilled to announce our Weill Institute 2025 Emerging Scholars –– eight outstanding grad students & postdocs selected for their innovative research, from institutions across the US and Canada. We'll welcome them to Cornell’s campus Oct 13–14, 2025. bit.ly/45f5GwQ
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Doerr Lab retweeted
mBio@mbiojournal29 Jul 2025
Molecular mechanism revealed for bacterial sugar overload. doi.org/10.1128/mbio.01729-2… @MRKmicrobes @DoerrLab
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Tissue-Like Multicellular Development Triggered by Mechanical Compression in Archaea biorxiv.org/cgi/content/shor… #biorxiv_cellbio
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📢 Attention antibiotic tolerance researchers! Our GIANT review of 50+ years' of clinical antibiotic tolerance data is now available online in Clinical Microbiology Reviews. Check it out here: journals.asm.org/eprint/UUSI… @ASMicrobiology @Hobbs_Lab_Micro @DeventerAshley @microclaire
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Latest preprint from our lab led by grad student @cassidyprints and her undergrad mentee @IsabellaNLin. She examines conservation and features of the programmed ribosomal frameshift in prfB. Presented by Cassidy at #GRC stress! biorxiv.org/content/10.1101/…

The evolution and functional significance of the programmed ribosomal frameshift in prfB

Release Factor 2 (RF2) is one of two peptide release factors that terminate translation in bacteria. In Escherichia coli , the gene encoding RF2, prfB , contains an in-frame premature RF2-specific...

biorxiv.org
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What a phenomenal seminar today at @CornellPathogen by @Hatzios_Lab — a tour de force of using chemical proteomics to discover new mechanisms of redox signaling in gut infection!🤩🤩🤩
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Out now in @NatureComms: Control of bacterial cell wall autolysins by peptidoglycan crosslinking mode @CavaLab_MIMS @FelipecavaM @DoerrLab nature.com/articles/s41467-0…

Control of bacterial cell wall autolysins by peptidoglycan crosslinking mode

Nature Communications - The regulatory mechanisms governing peptidoglycan-degrading autolysins remain poorly understood. In this work, Alvarez et al. show that lytic transglycosylase activity is...

nature.com
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We demonstrated a lowcost device that can detect deadly bacteria in drinking water. It shows, once again, that worldclass research can flourish in Nepal, despite limited resources. Here is news release by @OpticaWorldwide highlighting the important result. optica.org/about/newsroom/ne…
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Announcing the 2025 Bacterial and Archaeal Cell Biology and Development @GordonConf. We have amazing speakers and discussion leaders confirmed and look forward to (again) having our minds blown by all the remarkable science. Applications will start being accepted in the fall.
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What an honor for @cassidyprints and @CornellMicrobio to host Dr. @Nancy_Craig777 for our distinguished Portraits of a Microbiologist series. Thanks for returning to Wing Hall for such a moving and inspiring visit!
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The Cava lab is hiring!! Two new positions are available in our interdisciplinary group located in the north of Sweden @mims_umea @UmeaUniversity If you are passionate about science then it is time to apply! Looking forward to your application! 🙂
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This story involved many hands over many years led by @BertCorrea3 and @SaadleeS. Novel mechanisms of diversity generation in Acinetobacter baumannii resistance islands driven by Tn7-like elements academic.oup.com/nar/article…

Novel mechanisms of diversity generation in Acinetobacter baumannii resistance islands driven by...

Abstract. Mobile genetic elements play an important role in the acquisition of antibiotic and biocide resistance, especially through the formation of resis

academic.oup.com
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Phenotypic heterogeneity is generated by passive mechanisms like noise in gene expression, right? Not always! Check out an ACTIVE mechanism for generating diversity in a clonal bacterial population: biorxiv.org/cgi/content/shor…
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Kumaran and Tobi in the gorge! We love a surprise visit! @CornellMicrobio @RamamurthiLab @DoerrLab
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We are recruiting a postdoc to work on host-pathogen and pathogen-pathogen interactions! Check out the job ad and join us in beautiful Dunedin, New Zealand! :) otago.taleo.net/careersectio…
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Lab’s first pre-print! We found that loss of EF-P and the ABCF-family ATPase YfmR is lethal to B. subtilis due to translation failures during early elongation. Great work Hye-Rim Hong, @cassidyprints and @letian_wu! #ribosomes biorxiv.org/content/10.1101/…

Identification of factors that prevent ribosome stalling during early elongation

Protein synthesis is catalyzed by the ribosome and a host of highly conserved elongation factors. Most elongation factors that are conserved in all domains of life are essential, such as EF-Tu...

biorxiv.org
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Excited to share that I am starting a new chapter in clinical microbiology as a CPEP fellow at @JohnsHopkinsDOM 🧫🦠🔬
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