@DoloffLab

Doloff Lab: Immunoengineering & Regen Med @TTECJHU | Ugrad @Penn @PennBioeng | PhD @BU_Tweets | Postdoc @MIT | Assoc. Prof. @JohnsHopkins @JHUBME DEI FLI YNWA!

 Baltimore, MD
bme.jhu.edu/dolofflab/
Joined October 2018
  • Tweets4.2K
  • Following1.2K
  • Followers2.1K
360Media
Joshua C. Doloff retweeted
Nature Biotechnology
@NatureBiotechOct 15
T cell immunity declines with thymic atrophy, but thymic cell grafts rescue T cell function go.nature.com/3Jp6B72 rdcu.be/4C6R4B1ZJaWa

Mesenchymal thymic niche cells enable regeneration of the adult thymus and T cell immunity

Nature Biotechnology - T cell immunity declines with thymic atrophy, but thymic cell grafts rescue T cell function.

nature.com
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Joshua C. Doloff retweeted
Johns Hopkins BME@JHUBMESep 23
The @JohnsHopkins BME undergraduate program is once again ranked No. 1 in the nation by @usnews. Students dive into hands-on research from day one, helping drive innovation in human health. Read more: bme.jhu.edu/news-events/news…
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Joshua C. Doloff retweeted
Anirban Maitra@Aiims1742Sep 23
Proud of our @nyulangone Dean (and prior @Perlmutter_CC Director) Alec Kimmelman for his @Nature paper today: Hepatocytes promote liver metastasis of #PancreaticCancer by providing serine nature.com/articles/s41586-0… With @BarDafna @RichPossemato @KoelinaG @nyugrossman

Hepatocytes promote liver metastasis of pancreatic cancer by providing serine

Nature - Metastatic pancreatic ductal adenocarcinoma (PDAC) in the liver that lack the enzyme necessary to synthesize serine can reprogram hepatocytes to produce this amino acid, thus promoting...

nature.com
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Joshua C. Doloff retweeted
Nathaniel David
@NathanielEDavidSep 22
Cancer patients waste away partly because their own fat starts burning itself. The signal that starts it is not a cytokine. It is iron. Could this insight lead to a drug to prevent cachexia in cancer patients? doi.org/10.1038/s43018-026-0…

An iron-regulated methionine redox axis governs adipose browning and cancer cachexia

Nature Cancer - Chio and colleagues describe an iron-dependent pathway with a role in the induction of cancer cachexia-linked events such as adipose browning and identify methionine sulfoxide...

nature.com
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Joshua C. Doloff retweeted
Atanas G. Atanasov
@_atanas_Sep 20
An experimental blood test detected 87% of early-stage pancreatic ductal cancers in an international study.
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Joshua C. Doloff retweeted
Nature Rev Immunol@NatRevImmunolSep 18
Plasticity of the infant immune system during the perinatal period dlvr.it/TVXqvS

Plasticity of the infant immune system during the perinatal period

Nature Reviews Immunology - Immune plasticity during the perinatal period enables mammalian offspring to successfully navigate the transition from prenatal, intrauterine life to postnatal,...

nature.com
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Joshua C. Doloff retweeted
Dr. Thomas Ichim
@exosomeSep 14
Macrophages eating living cells...NATURE paper ! nature.com/articles/s41586-0…

Submicrometre sampling of living cells by macrophages

Nature - Macrophages can sample antigens from living cells through a trogocytosis-like mechanism that routes ingested material away from degradation, a finding that delineates a previously unknown...

nature.com
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Joshua C. Doloff retweeted
Dr. Thomas Ichim
@exosomeSep 14
Pain producing neurons around #cancer generate immune suppressive molecules... The neuroimmunology of cancer is crazy...and its an area that is highly overlooked.... nature.com/articles/s41586-0…

Nociceptor neurons affect cancer immunosurveillance

Nature - Melanoma cells interact with pain-mediating sensory neurons by increasing their release of the neuropeptide CGRP, which increases the exhaustion of CD8+ T cells and thus promotes the...

nature.com
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Joshua C. Doloff retweeted
John Hickey@johnhickey22Sep 10
We’re hiring! Join the Hickey Lab at Duke as a full-time Research Assistant developing reproducible agent-based models of human tissues. We seek experience in Python, computational modeling, and biology. 1–2 years, Durham, NC. Apply/share: forms.gle/Abfbwb4B8a8WycGF6
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Joshua C. Doloff retweeted
Michael Alexanian@m_alexanianSep 3
Excited to share our new review in @CellCellPress. We propose fibrosis is a reversible state encoded in chromatin circuits shaped by immune-stromal crosstalk, and that rewiring this logic may offer durable therapeutic paths. @GladstoneInst authors.elsevier.com/sd/arti…
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Joshua C. Doloff retweeted
Eric Topol
@EricTopolAug 30
Engineering our immune cells has successfully treated many types of cancer and even led to cure of some autoimmune diseases. But the engineering of cells was done outside the body, is highly complex, takes 3 to 6 weeks, and is not scalable. But now there are many in vivo (inside the body) Phase 1 clinical trials reading out soon. Watch this space. nature.com/articles/d41573-0…
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Joshua C. Doloff retweeted
Cell Press@CellPressNewsAug 29
The longest lived people among us, called "supercentenarians," have an abundance of cancer-killing immune cells, study finds. Learn more in Cell Reports: cell.com/cell-reports/fullte… Kosuke Hashimoto, Nobuyoshi Hirose, Piero Carninci, Yasumichi Arai, & colleagues @cellreports
first page of paper: CD4 CTLs in supercentenarians: Signs of adaptive expansion in healthy aging

ALT first page of paper: CD4 CTLs in supercentenarians: Signs of adaptive expansion in healthy aging

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Using single-cell immune profiling, scientists from the University of Osaka analyzed T cells from #supercentenarians and found that cytotoxic T lymphocytes begin to expand around the age of 100, characterized by sequential CD27/CD28 loss without exhaustion. bit.ly/4y8im5t 📖: @CellReports
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Joshua C. Doloff retweeted
Ran Blekhman@blekhmanAug 9
Huge faculty recruitment effort at the University of Chicago -- a division-wide, open-rank search looking to hire about 20 faculty across 5 research areas in biology. Come be our colleague! Full announcement: uchicago.app.box.com/s/ckih9…
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Joshua C. Doloff retweeted
Science Immunology@SciImmunologyJul 20
#Bcells favor different #memory fates in response to barrier tissue infections, forming plasma cells in the gut and memory B cells in the lungs in mice. Learn more in Science #Immunology: scim.ag/4wae4tK
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Happy to share a recent publication with our collaborators at Wilmer on crystalline drug delivery to the eye to treat wet age-related macular degeneration @JCRnEDITORS! sciencedirect.com/science/ar… & Recent press release: bme.jhu.edu/news-events/news… @JHUBME @TTECJHU @HopkinsMedicine
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Joshua C. Doloff retweeted
Science Immunology@SciImmunologyJun 22
A new Science #Immunology study in mice demonstrates how group B #streptococcus infections in the meninges can trigger dural #macrophage depletion and trigger emergency monocyte production in the skull and peripheral marrow. scim.ag/4aHKtiw
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Joshua C. Doloff retweeted
Johns Hopkins BME@JHUBMEJun 23
Tilak Ratnanather, associate research professor at #HopkinsBME, has received the 2026 OHBM Diversity and Inclusivity Champion Award for advancing accessibility and inclusion in brain mapping and neuroimaging. Congratulations! 👏 👏 👏 bme.jhu.edu/news-events/news…
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Joshua C. Doloff retweeted
Johns Hopkins BME@JHUBMEJun 12
New research by #HopkinsBME engineer @JustusKebschull reveals the brain contains 28 distinct types of dopamine neurons—far more than scientists previously thought. 🧠✨ Read more 👉 bme.jhu.edu/news-events/news…
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Congratulations, Andre! cbsnews.com/baltimore/news/m…

Graduate from Maryland's Johns Hopkins University joins NASA's Artemis III crew

A graduate of Johns Hopkins University in Baltimore is joining NASA's 2027 Artemis III crew as a mission specialist.

cbsnews.com
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