University of Virginia/Tumor Microenvironment & Angiogenesis Lab; co-EIC @ Angiogenesis
Charlottesville, VA
Joined September 2016
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Nice work from our recent MD/PhD student who shows how melanoma cells travel along blood vessels within the brain microenvironment. Congrats to Sarah! nature.com/articles/s41416-0…
In vivo fluorescent labeling and tracking of extracellular matrix | Nature Protocolsm nature.com/articles/s41596-0…
Congrats to our graduate student who made the cover of Cancer Research! Follow the link to find out how specialized fibroblasts "help" cancer cells enter lymphatic vessels and spread to lymph nodes.
pubmed.ncbi.nlm.nih.gov/3720…
Pathological angiogenesis: mechanisms and therapeutic strategies link.springer.com/article/10…
Happy to share our latest collaborative work with @kamm_lab and @ChiappinelliLab @NatureComms where targeting an epigenetic factor in tumor vasculature augments IFN response; blood vessels thus become like "honey to a fly" and permit CD8+ T-cell entry. rdcu.be/c9SFy
3-Dimensional Imaging Reveals Immune-Driven Tumour-Associated High Endothelial Venules as a Key Correlate of Tumour Rejection Following Depletion of Regulatory T Cells | Cancer Research Communications | American Association for Cancer Research aacrjournals.org/cancerresco…
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Periostin+ stromal cells guide lymphovascular invasion by cancer cells biorxiv.org/content/10.1101/…
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Reprogrammed Schwann Cells Organize into Dynamic Tracks that Promote Pancreatic Cancer Invasion | bioRxiv biorxiv.org/content/10.1101/…
The MYC oncogene — the grand orchestrator of cancer growth and immune evasion | Nature Reviews Clinical Oncology nature.com/articles/s41571-0…
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Mature tertiary lymphoid structures predict immune checkpoint inhibitor efficacy in solid tumors independently of PD-L1 expression | Nature Cancer nature.com/articles/s43018-0…
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Nice work from @CarmelietLab showing how, at the single cell level, cancer cells may out smart anti-angiogenic therapies by co-opting pre-existing vasculature. cell.com/cell-reports/fullte…
Conserved pan-cancer microenvironment subtypes predict response to immunotherapy: Cancer Cell cell.com/cancer-cell/fulltex…
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An incredibly comprehensive review on high endothelial venules in cancer/immunity published in Angiogenesis.
link.springer.com/article/10…
Please retweet! A postdoctoral fellow position is available in our group to work on projects related to perivascular invasion by cancer cells in brain metastasis/tumor immune microenvironments. More information at: mic.med.virginia.edu/dudley/
A terrific review on how to target the tumor endothelium to enhance anti-tumor immunity.
nature.com/articles/s41571-0…
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Examining metastatic behavior within 3D bioprinted vasculature for the validation of a 3D computational flow model | Science Advances advances.sciencemag.org/cont…
A uniform format for manuscript submission: Cell 🤓yes, please. cell.com/cell/fulltext/S0092…
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Emerging strategies for treating metastasis | Nature Cancer nature.com/articles/s43018-0…
Melanoma models for the next generation of therapies - ScienceDirect sciencedirect.com/science/ar…
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