Dale Staten

It’s interesting watching @FDATobacco be in this really awkward position of trying to communicate to adult smokers that vaping can drastically improve their life, while also turning to those under 21, trying to tell them that Vaping will ruin their life

Evidence 🧵 2010 Nicotine vaping avoids combustion (the main source of smoking harm), early peer-reviewed lab work comparing cigarette smoke vs e-cig aerosol characteristics “Conventional and electronic cigarettes (e-cigarettes) have different smoking characteristics” academic.oup.com/ntr/article… 2011 Nicotine vaping is less harmful than continuing to smoke (harm reduction framing supported by the then-available evidence base) “Electronic Cigarettes as a Harm Reduction Strategy for Tobacco Control: A Step Forward or a Repeat of Past Mistakes” vaportechnology.org/wp-conte… 2012 Nicotine vaping is less harmful than continuing to smoke (measured indoor-air pollutants far lower vs cigarette smoke) “Comparison of the effects of e-cigarette vapor and cigarette smoke on indoor air quality” articles.researchsolutions.c… 2013 Nicotine vaping is less harmful than continuing to smoke (cigarette smoke extract far more cytotoxic than e-cig vapor extract in vitro) “Cytotoxicity evaluation of electronic cigarette vapor extract… comparison with tobacco cigarette smoke extract” gwern.net/doc/nicotine/2013-… 2014 Nicotine vaping is less harmful than continuing to smoke (key toxicants measured much lower in vapor vs smoke) “Levels of selected carcinogens and toxicants in vapour from electronic cigarettes” tobaccocontrol.bmj.com/conte… 2015 Nicotine vaping is less harmful than continuing to smoke (TSNAs are minimal in e-cig liquid/aerosol; plus “dry puff” conditions matter for aldehydes) “Tobacco-Specific Nitrosamines in Electronic Cigarettes: Comparison between Liquid and Aerosol Levels” mdpi.com/1660-4601/12/8/9046 2016 Nicotine vaping is less harmful than continuing to smoke (broad toxicant panel shows dramatically lower emissions vs cigarette smoke) “Chemical Composition of Aerosol from an E-Cigarette: A Quantitative Comparison with Cigarette Smoke” pubs.acs.org/doi/pdf/10.1021… 2017 Nicotine vaping is less harmful than continuing to smoke (biomarkers of carcinogens/toxins far lower in long-term exclusive vapers vs smokers) “Nicotine, Carcinogen, and Toxin Exposure in Long-Term E-Cigarette and Nicotine Replacement Therapy Users” discovery.ucl.ac.uk/id/eprin… 2018 Nicotine vaping is less harmful than continuing to smoke (switching studies show toxicant biomarkers fall quickly when smokers switch) “Biomarkers of Tobacco Exposure Decrease After Smokers Switch to an E-Cigarette or Nicotine Gum” academic.oup.com/ntr/article… 2019 Nicotine vaping is less harmful than continuing to smoke (population biomarker data: exclusive e-cig users show markedly lower toxicant exposure vs smokers) “Comparison of Nicotine and Toxicant Exposure in Users of Electronic Cigarettes and Cigarettes” jamanetwork.com/journals/jam… 2020 Nicotine vaping is less harmful than continuing to smoke (comparative chemistry reviews continue to show substantially lower toxicant emissions vs cigarettes) “The Evolving E-cigarette: Comparative Chemical Analyses of E-cigarette Aerosols” frontiersin.org/journals/tox… 2021 Nicotine vaping is less harmful than continuing to smoke (fewer compounds + lower concentrations in e-cig aerosol vs cigarette smoke) “The Chemical Complexity of e-Cigarette Aerosols Compared With the Smoke from a Tobacco Burning Cigarette” frontiersin.org/journals/che… 2022 Nicotine vaping is less harmful than continuing to smoke (24-week randomized clinical trial: exposure/potential-harm biomarkers improve after switching) “Biomarkers of Exposure and Biomarkers of Potential Harm… in a 24-week, Randomized, Clinical Trial” academic.oup.com/ntr/article… 2023 Nicotine vaping is less harmful than continuing to smoke (real-world biomarker comparisons: smokers highest; exclusive ENDS lower) “Comparison of biomarkers of exposure among US adult smokers, ENDS users, dual users and nonusers, 2018–2019” nature.com/articles/s41598-0… 2024 Nicotine vaping is less harmful than continuing to smoke (systematic review/meta-analysis: TSNA exposure is far higher in smokers than exclusive vapers) “Exposure to Tobacco-Specific Nitrosamines Among People Who Vape, Smoke, or do Neither: A Systematic Review and Meta-Analysis” academic.oup.com/ntr/article… 2025 Nicotine vaping is less harmful than continuing to smoke (comparative emissions synthesis: TSNAs lower in e-cig aerosol than cigarette smoke) “Tobacco-specific nitrosamine exposure from electronic cigarettes versus combustible cigarettes” frontiersin.org/journals/onc… When does, 'not enough evidence yet' stop being cautionary and turn into denial? 16 years of evidence on any product other than nicotine would have been policy already. #Science

After 16 years, my @YouTube channel (GrimmGreen) was terminated today with no real explanation. I’ve built my content around harm reduction, helping adult smokers quit, and advocating for science-based policies. This feels like a huge mistake. If you believe in THR, free speech, and the mission we’ve been on, please help me get YouTube’s attention. @TeamYouTube I’m asking for a real human to review my case. I’ve never promoted anything illegal. I’ve never targeted youth. I’ve worked tirelessly to be a responsible voice in the vaping and harm reduction space. But like many creators in this space, it seems I’ve been swept up in an overly aggressive moderation wave.