La connaissance est le pouvoir
Joined January 2021
- Tweets231
- Following313
- Followers36
- Likes6.4K
8ème merveille retweeted
They took 300 people with high cortisol and put them on magnesium + potassium.
Their cortisol DROPPED 45%!
Mineral deficiency is a MAJOR cause for high cortisol and low metabolism.
Glucose oxidation relies heavily on those minerals, this why diabetics benefit from them.
(diabetics usually also have high cortisol)
8ème merveille retweeted
Gemini 4 Argon has mastered thinking, but forgotten how to answer 💀
It spends hundreds of seconds reasoning, only to show "Model unavailable, reconnecting" and restart the entire process.
All that waiting, just to start from zero again ??
Anyone else facing this?
8ème merveille retweeted
Testosterone decline is blamed on aging. A new study analyzing nearly 5,000 men found age explains only 2.5% of testosterone variation. Body fat explains 18-20%. The difference matters clinically.
Researchers at the U.S. Army Research Institute of Environmental Medicine analyzed National Health and Nutrition Examination Survey data from 2011-2016. They included men aged 20 to 59 years with measured testosterone levels and body composition scans.
The goal was to separate what actually drives testosterone decline: chronological aging or the body fat accumulation that typically accompanies aging.
Key findings:
• Age alone explained only 2.5% of testosterone variation across men
• Total body fat percentage explained 18.2% of variation
• Visceral fat (belly fat surrounding organs) explained 18.4%
• Waist circumference explained 19.9%, slightly better than advanced imaging
• These patterns held across multiple testosterone thresholds (300, 250, 200, 150 ng/dL)
Think of this as explanatory power. If you only know a man's age, you can barely predict his testosterone level. If you know his waist circumference, you have 8 times more predictive information.
The study measured body composition using dual-energy X-ray absorptiometry, the same technology used for bone density scans. This provides precise measurements of total body fat percentage and visceral adipose tissue area.
Visceral fat is the metabolically active fat stored around your abdominal organs. It's distinct from subcutaneous fat, the fat you can pinch under your skin. Visceral fat drives metabolic dysfunction through multiple pathways.
How does body fat suppress testosterone?
First, fat tissue contains aromatase, an enzyme that converts testosterone into estradiol. More fat means more conversion, lowering circulating testosterone.
Second, visceral fat promotes insulin resistance. Insulin resistance reduces production of sex hormone-binding globulin (SHBG) in the liver. SHBG is a protein that binds and transports testosterone in your blood. Lower SHBG means lower measured total testosterone.
Third, visceral fat releases inflammatory molecules that suppress the hypothalamic-pituitary-gonadal axis. This is the hormonal control system that signals your testes to produce testosterone. Chronic inflammation dampens this signaling.
The relationship is bidirectional. Body fat suppresses testosterone. Low testosterone promotes fat accumulation by reducing lipolysis (fat breakdown) and allowing increased fat cell development. This creates a reinforcing cycle.
Across every age group, men with testosterone below 300 ng/dL had substantially more body fat than men above that threshold.
For men aged 30-39:
• Low testosterone group: 30.3% body fat, 130.5 cm² visceral fat
• Normal testosterone group: 26.4% body fat, 94.6 cm² visceral fat
The body composition differences were larger and more consistent than age differences.
Testosterone levels declined from ages 20-29 to 40-49, then plateaued at 50-59. This plateau occurred despite continued increases in body fat, suggesting that the testosterone suppression threshold is crossed primarily during midlife rather than progressively with aging.
Waist circumference performed as well as advanced imaging for predicting testosterone levels. A waist circumference above 110-115 cm corresponds to visceral fat area above 300 cm², where predicted testosterone drops by more than 400 ng/dL compared to men with minimal visceral fat.
This has practical implications. Clinicians can use a tape measure instead of expensive body composition scans to assess obesity-related testosterone suppression.
The researchers also examined whether these associations persisted after accounting for SHBG. In models adjusted for SHBG, body fat remained inversely associated with testosterone. This indicates that fat suppresses testosterone both directly and through SHBG reduction.
As always, we have some limitations of this study. The study is cross-sectional, meaning it captures a snapshot in time rather than tracking individuals over years. Why does this matter? This prevents establishing whether fat accumulation causes testosterone decline or whether low testosterone drives fat gain.
The bidirectional nature of the relationship means both processes likely occur simultaneously, creating the reinforcing cycle described earlier.
NHANES measured testosterone once, without confirmatory testing. Clinical hypogonadism requires repeat measurements, symptom assessment, and evaluation of other hormones. These findings describe biochemical testosterone concentrations, not clinical diagnoses.
The study included only men aged 20-59 years. Findings may not apply to older men, where primary testicular aging may play a larger role independent of body composition.
What does this mean clinically?
Current guidelines recommend evaluating reversible causes before starting testosterone replacement therapy. In men with excess body fat, particularly visceral fat, addressing metabolic health and weight loss should be prioritized.
Weight loss studies, including trials of GLP-1 receptor agonists like semaglutide and liraglutide, show that reducing adiposity can increase endogenous testosterone production. This supports a functional, potentially reversible suppression rather than permanent testicular failure.
Experimental data reinforces this. Healthy lean men subjected to prolonged caloric restriction and high physical stress can experience testosterone decline to near-castrate levels, with rapid recovery upon refeeding. This demonstrates that testosterone suppression can represent an adaptive response to metabolic stress rather than irreversible dysfunction.
The proliferation of direct-to-consumer testosterone therapy platforms raises concerns about inappropriate prescribing. If low testosterone is attributed to inevitable aging rather than modifiable metabolic factors, men may receive lifelong androgen therapy when lifestyle interventions could restore endogenous production.
This matters for both individual health and population health. Testosterone therapy carries cardiovascular and behavioral risks. It suppresses natural production, creating dependence. If the underlying cause is reversible metabolic dysfunction, addressing that cause is preferable to pharmacologic replacement.
The framework matters. If testosterone decline during adulthood primarily reflects the metabolic burden of excess adiposity rather than intrinsic gonadal aging, then the decisions made about physical activity, diet, and body composition in your 30s and 40s shape your hormonal status in your 50s and 60s.
Body fat accumulation is not inevitable with aging. It reflects the cumulative balance between energy intake, expenditure, and metabolic health across decades. Maintaining lower body fat, particularly visceral fat, appears to preserve testosterone concentrations independent of chronological age.
The study provides a quantitative framework for understanding what drives testosterone variation in adult men. Chronological aging contributes minimally. Body composition, particularly visceral adiposity, explains substantially more variation and represents a modifiable target for intervention.
8ème merveille retweeted
Models by @GoogleDeepMind scale better on cost than their rivals.
Gemini 4 Carbon is the prime example. As tasks get more demanding, every rival gets more expensive relative to Carbon.
For a typical task, GPT-6 Astra by @OpenAI costs 3.4× as much, Claude Opus 5.5 by @AnthropicAI costs 3.9× as much, and GPT-6.1 Sol is the cheaper option at about half of Carbon’s cost (0.54×).
Across the 5% most expensive sessions, Carbon’s position improves against all three. Opus edges up to 4.2×, Astra’s cost roughly doubles relative to Carbon, and Sol’s discount shrinks.
This in turn can translate into meaningful savings across real-world tasks such as building an Android security app, one of many long-horizon tasks that our Agent Arena users delegate to their agents.
As tasks get more complex, @GoogleDeepMind and @XiaomiMiMo are the biggest winners in the Agent Arena.
On cheaper tasks, @OpenAI and @AnthropicAI hold 10 of the 11 frontier spots. On the most expensive 5% of sessions, they hold just 7. The freed spots go to Google’s Gemini 4 Argon and Xiaomi’s MiMo-V2.6 Flash and Pro.
These shifts matter as sessions costing $100 or more are not uncommon across real-world use cases coming from Agent Arena. Even within the last 2 weeks, more than 1,000 sessions crossed that boundary, and choosing a suboptimal model might have had a meaningful impact on that final bill.
8ème merveille retweeted
BREAKING: Scientists confirm that low iron directly reduces the brain's ability to produce dopamine — because iron is a required cofactor in the process.
Low ferritin shows up consistently in both ADHD and autism. And it's a level almost nobody thinks to check...,::. 1//6
8ème merveille retweeted
Music reduces mental fatigue and restores related brain rhythms.
Press play, don’t push harder.
8ème merveille retweeted
Both too little and too much zinc can harm your essential fatty acid conversion.
Even a marginal zinc deficiency (6mg/day with some phytates) can slash FADS1 activity by 29% in just two weeks.
But the activity and the associated lipid changes did not fully normalize on 10 mg/day but did on 25 mg/day.
So in general keep in mind that a baseline amount of zinc (8-15mg/day usually) is required for the Δ5 and Δ6 desaturase enzymes.
But too much can also significantly decrease desaturase activity.
This is why ridiculously high-dose zinc supplements can give you symptoms similar to those of following a diet low in O3s when used for prolonged time periods.
It's not just about harming the zinc:copper ratio.
8ème merveille retweeted
Music is a longevity therapy
> lowers heart rate
> lowers blood pressure
> lowers cortisol
> lowers anxiety and restlessness
Protocol: a song you love.
104 randomized trials
9,617 people
8ème merveille retweeted
Here are some random facts about your health that you might not be aware of:
-Kiwifruit supplementation improved vitality and mood within 4 days, peaking around 14-16 days
-Every 5-gram increase in daily fiber intake correlated with an approximate 5% drop in the risk of depression.
-Women who consumed less than the recommended amount of red meat were twice as likely to be diagnosed with a clinical depressive or anxiety disorder.
-Neuroscientists often can not distinguish between people with mild/moderate TBIs and people who have been exposed to mold
-Bibliotherapy (reading) is found to be highly effective for reducing long-term depressive symptoms in adults.
-Office job workers had higher levels of anxiety and depression than those working in manufacturing jobs
-People with major depressive disorder have serum zinc concentrations averaging roughly 1.85 µmol/L lower than healthy controls.
Why?
Well in a nutshell, zinc is crucial for maintaining homeostasis in BDNF, NMDA, GPR39, microglial cells, ACTH and more.
-Believe it or not, there's some research suggesting that botox helps with depression despite it being toxic.
The main theory is that the brain relies on a bidirectional feedback loop called facial feedback.
So when you feel sad, you frown for example.
However, if your forehead muscles physically cannot frown, the feedback loop to your amygdala is interrupted, telling your brain that the distress is less severe than it thinks.
So instead of botox, pay more attention to your facial expressions and artificially manufacture more positive ones :)
-When you are depressed, it's a good idea to pay attention to your sleep and circadian health.
But in the short term, staying awake for 36 hours straight has been documented since the 1970s as one of the fastest-acting antidepressant interventions in existence.
IF you have unipolar depression. If you have bipolar depression it needs way more caution (triggers full mania in 5% of people and hypomania in 6%) because well, this works mainly by rapidly increasing dopamine, norepinephrine and BDNF by downregulating NET for example (NET is responsible for sweeping norepinephrine out of your brain's synapses).
Note: It's not a long term strategy.
For roughly 80% of responders, the antidepressant effect disappears entirely after the very next period of sleep.
-Some of the benefits SSRIs might actually come from modulating ZnT-3, which is solely responsible for packing zinc into synaptic vesicles.
So they might force more zinc out of tight intracellular storage and into the active synaptic clefts of the prefrontal cortex.
-Slow COMT + mercury exposure = cooked brain (especially in children).
Mercury is well-documented to impair catecholamine degradation by interfering with S-adenosylmethionine (the methyl donor required by COMT).
This reduces COMT activity and thus leads to accumulation of norepinephrine, epinephrine, and dopamine.
The same SAM disruption can also impair phenylethanolamine N-methyltransferase (PNMT), shifting the adrenal output toward more noradrenaline and less adrenaline.
-NAC is very effective for compulsive disorders.
In a lot, if not most, compulsive disorders and BFRBs (hair pulling etc), there is dysregulation of glutamate homeostasis in the cortico-striatal circuits.
Mainly, the projection from the prefrontal cortex to the nucleus accumbens (NAc) fires excessively and this hyperactivity drives the "urgency" and loss of top-down behavioral control, making repetitive behaviors highly compulsive.
The extra cysteine from NAC stimulates the cystine-glutamate antiporter.
This increases extracellular glutamate levels outside the synapses/binds to metabotropic glutamate receptors(*), which shut down the hyperactive release of glutamate into the synapse via a negative feedback.
(*)primarily mGluR2/3)
BUT the same reason why NAC helps with compulsive disorders is why, if you use big doses for prolonged time periods, you will end up with anhedonia if you don't have one.
The same mechanism that dampens the "pathological noise" causing cravings or tics blunts the clean glutamatergic signals required for learning and reward processing for example. This was the short answer.
-Baicalin (a flavonoid found in Chinese skullcap) increased VMAT2 levels and enhanced dopamine balance in the brain.
-Plasma zinc and erythrocyte magnesium should be considered as biological state markers and used as such in both major depression and bipolar disorder.
-Ketosis might be a good additional tool to fight addiction more easily.
A ketogenic diet increases baseline levels of adenosine in the brain.
Adenosine receptors naturally pair with dopamine receptors to form functional complexes.
When adenosine levels rise, they directly repress hyperactive dopamine signaling.
Because cocaine's behavioral effects (like rearing and hyper-ambulation) rely on massive surges of dopamine, adenosine acts as a built-in brake.
On top of that:
-Ketosis increases the production of GABA
-β-OHB blocks the overactivation of an enzyme called CaMKII-α through a process known as β-hydroxybutyrylation.
By dampening this enzyme in brain areas like the hippocampus, the diet disrupts the structural "drug memories" and behavioral conditioning that drive cocaine addiction.
-A landmark 2019 follow-up study found that 44% of participating children no longer met the diagnostic threshold for autism spectrum disorder two years after completing a specialized form of fecal microbiota transplantation.
-Drinking at moderate levels (14–21 units per week (a pint a day)) tripled the odds of right-sided hippocampal shrinkage compared to abstaining.
Higher intake (over 30 units weekly) raised this risk even further.
The main mechanisms seem to include acetaldehyde and brain iron accumulation.
At the start of the study, 83% of the children were rated as having "severe" autism.
Two years after treatment, that number dropped to 17%.
-Participants who met the RDA for zinc, copper and selenium had significantly lower odds of depression.
-Aluminum inhibits protein phosphatase 2A, which helps keep tau and neurofilaments dephosphorylated.
It also downregulates TH-immunoreactive neurons inside the substantia nigra.
-Cracking up your window while you sleep might improve your brain health more than you think.
Cognitive scores drop roughly 50% at 1,400ppm compared to the 550 ppm baseline.
-Rates of depression correlate with the geographical distribution of deuterium in the natural water in the US population.
-Consuming a modified Mediterranean ketogenic diet reverses the peripheral lipid signature of Alzheimer’s disease in humans.
-Studies from the United Kingdom and Sweden indicate that the risk of depression is increased by at least 20%, with the former (over 1 million participants) reporting an increased risk with the number of courses and agents used, that persists with a slow decline over the ten years following exposure
-Inadequate dietary omega-3 intake after birth may similarly deplete maternal tissue reserves, potentially contributing to postpartum mood changes or cognitive fatigue
-In a study of 18 patients diagnosed with schizophrenia, 15 (83.3%) had positive serum FRα autoantibodies compared to only 1 in 30 controls (3.3%)
FRα autoantibodies can interfere with how B9 is transported across the blood-brain barrier into the central nervous system.
This blockage can cause a lack of folate in the brain even when blood levels of folate appear completely normal.
Some patients in related observations showed clinical improvement after receiving high-dose folinic acid (leucovorin), which can bypass the blocked receptors.
-Approximately 30% to 40% of patients with moderate/severe depression experience a meaningful improvement in symptoms with placebo and for individuals with mild-to-moderate depression, that response rate can climb to 70%
-The more vitamin D increases (up to a point), the less depression a person experiences.
-A high magnesium intake is associated with larger brain volumes.
-Glutathione levels are significantly reduced in the occipital cortex of patients with major depressive disorder (MDD).
-There's a higher abundances of certain bacteria like Firmicutes, Clostridia, Actinomyces, Bacteroides, Lachnospiraceae, Blautia, and Dorea are noticed in individuals with suicidal behaviors.
-In German rare-disease clinics, more than half of adults with unexplained symptoms had a current mental disorder and in almost 54% of those cases the mental illness alone explained the whole picture.
-Adolescents with social anxiety had a shifted microbiome (higher Prevotella, lower Parasutterella).
Transplanting that community into newborn rats produced anxiety-like behavior, social deficits, and metabolic changes in medial frontal cortex
-People with MDD often have 20–60% fewer butyrate producers.
-Stool from depressed humans, put into rodents, transfers anhedonia and anxiety-like behavior plus a twisted tryptophan metabolome
-Childhood unpredictability (chaotic routines, who shows up, what happens next) predicts depression even when ACE scores are zero.
-Ten years after clinical depression, about 10% of people are not just “not depressed”, they score above a quarter of never-depressed adults on well-being.
This means that recovery can overshoot baseline
-Suicide and depression rates climb with altitude in U.S.
-Youth cannabis use has been tied to higher later odds of schizophrenia (~+52%), recurrent MDD (~+30%), and anxiety (~+21%)
-Finnish men who sauna 4–7 times a week (vs once) had on the order of 65% lower dementia/Alzheimer risk and about 77% lower psychosis risk over decades
-One session of whole-body hyperthermia (core ~38.5 °C) produced antidepressant effects that were still visible six weeks later in a small RCT
-Antibiotics can be life-saving, but they are not Tic Tacs.
Do two or more rounds of them each year and your relative risk of depression increases by as much as 40%.
"I'll just take probiotics".
They can help but it's not how this works.
The effects of antibiotics extend far beyond simply lowering the count of good bacteria.
Classes such as fluoroquinolones and penicillins bind to and block GABA receptors in the brain for example.
-Impaired glucose metabolism is not only relevant for Alzheimer's when it comes to mental health/brain related issues but pretty much every single one because, well, the brain is a very glucose-sensitive tissue.
Areas like the hippocampus, amygdala, and prefrontal cortex rely heavily on GLUT4.
-Sleep irregularity is consistently tied to 26–53% higher dementia risk.
-Shift work is associated with 30–33% higher overall adverse mental health outcomes.
-Brisk walking for an extra 150 minutes per week is associated with living ~4.5 years longer on average.
-Social/friendship support interventions can lower depression susceptibility by around 30% in relevant reviews.
-Being insulin resistant increases your risk for depression by 2X.
-A single bout of RT or HIIT can increase levels of anti-cancer myokines and reduce the growth of MDA-MB-231 cells in vitro in survivors of breast cancer, potentially contributing to a lower risk of recurrence.
-Vitamin E therapy prevents hyperoxaluria-induced calcium oxalate crystal deposition in the kidney by improving renal tissue antioxidant status.
-CoQ10 levels in hyperthyroid patients were found among the lowest detected in human diseases.
-Lithium appears to be protective against aluminum toxicity in neurons.
-Creatine loading can increase DHT by 56% after 7 day and 40% if 5-10 grams are used after.
-You have a higher chance of being gay if your mom was hypothyroid during pregnancy.
-40g of dark chocolate can reduce menstrual pain as effectively as 400 mg ibuprofen.
-Colostrum is 3 times more effective than the flu vaccine.
-Night-shift workers show substantially higher rates of irritable bowel syndrome.
-When it comes to exercise a 2022 study saw the lowest risk of mortality at 150-300 min/week of leisurely vigorous physical activity, 300-600 min/week of leisurely moderate physical activity or a combination of both.
-There's a chance that we could achieve a COVID mortality rate pretty close to zero if everyone had a vitamin D level >50 ng/mL. Yes, zero.
-Vitamin D, A, B9 and zinc intake were lower in regions with the highest COVID-19 incidence and mortality.
-Choline is crucial for proper brain development and gestational choline deficiency in animals leads to lifelong cognitive deficits.
-Zinc at just 25mg can reduce depression by half and lower cortisol by up to 70% at 50mg.
-In rats, taurine protects their thyroid from fluoride exposure.
-Dietary vitamin B6 and vitamin E are associated with decreased odds of periodontitis.
-1–2 mg/day of elemental lithium (as lithium orotate or from mineral water) cuts suicide rates by up to 80% in high-lithium regions and reduces dementia progression in RCTs at 5 mg/day.
-Children with autism and/or ADHD seem to have impaired B6 utilization.
-High methionine, low folate and low vitamin B6/B12 (HM-LF-LV) diet causes neurodegeneration and subsequent short-term memory loss.
-Allithiamine can not only alleviate hyperglycaemia-induced endothelial dysfunction, but also reduce the level of advanced glycation end-products (AGEs).
-Rosemary can also reduce the level of advanced glycation end-products (AGEs).
-Astragalus supports mitochondria by scavenging harmful free radicals, reducing lipid peroxidation, increasing glutathione levels and it boosts endurance by 127% in mice.
-A combination of multiple lifestyle factors (sleep, activity, diet, social connection, etc.) can be linked to 50%+ lower depression risk compared with an unfavorable profile.
-Vitamin D dose-dependently reduces symptoms of depression.
-Cannabis is cooking your brain and testicles (CBD can be helpful though).
-Beta-caryophyllene (found in cloves and black pepper) increases salivary testosterone levels by 16%.
-Taurine is an essential neuromodulator during cortical development.
-Niacinamide can reduce plaque buildup in the brain and NMN improves insulin resistance.
-Children with autism often can not utilize folate properly due to genetic impairments.
-Not consuming enough B vitamins literally shrinks parts of the brain (especially B12).
-B1 is crucial for gut motility and stimulating digestive enzymes.
-High dose inositol (12–18 g/day) has antidepressant efficacy equal to SSRIs in multiple RCTs, with almost zero side effects.
-A copper:zinc imbalance (high Cu/low Zn) is found in A LOT of cases of postpartum depression and violent behavior in teens.
-10,800 FU of nattokinase per day showed significant reductions in atherosclerosis progression.
-Patients who passed away from COVID had low iron, vitamin B12 and vitamin D while also having high HbA1c.
-200 mg of vitamin C and 500 µg of B12 per day improve blood pressure, blood flow and reduce arterial thickness.
-Vitamin C lowers cortisol by up to 40% in some cases, increases oxytocin, supports cardiovascular health, increases dopamine and lowers prolactin.
-300 mg/day of ubiquinol (active CoQ10) reduces migraine frequency by up to 50–60%.
-Thiamine (B1) at high doses (up to 1.5 grams) cuts fatigue nearly in half in patients with MS.
-The first 27 longest living humans in history are women, and 80% of people over the age of 100 are women
-Plasma donation and blood donation have been seen to decrease the amount of forever chemicals in firefighters.
-Muscle androgen receptor density predicts muscle growth from resistance training far better than circulating levels of hormones
-PQQ seems good for elderly individuals with mild cognitive impairment.
-20 g/day of creatine loading + 5 g maintenance for 8 weeks cuts pain by 50% and fatigue by 60% in several small RCTs for fibromyalgia.
-High prolactin and low thyroid hormones are common in MDD.
-300 mg/day of ubiquinol cut cardiac death by 43% and total mortality by 42% over 2 years in patients with moderate to severe heart failure.
-High doses of biotin can lower blood sugar by half in diabetics and increase testosterone quite a lot (even by 3X).
-Vitamin C therapy might in fact increase the survival rate across all types of cancers by up to 4X.
-Vitamin A improves A LOT of symptoms of autism.
-Not getting enough selenium is so problematic that people with a baseline serum selenium concentration below approximately 106 ng/mL (within the low-normal range) had significant reductions in total cancer mortality and incidence of lung, colorectal and prostate cancers when supplemented with 200 µg/day of selenium.
-Separating fats and carbs in meals can minimize the simultaneous availability of both substrates, reducing competition and potentially improving glucose clearance.
-High dose riboflavin (400mg) works for up to 70% of migraineurs within 6 weeks.
-Vitamin A is superior to steroids for masculinization before 12y.o.
-10–15 g of glycine at night can improve insulin sensitivity the next day by even up to 50%.
-Men taking 600 mg/day of CoQ10 for 12 months reported a 113.7% increase in sperm concentration and a 104.8% increase in progressive motility.
-A single 20 g dose of creatine almost completely negates the cognitive decline from 24–36 hours of sleep loss.
-I can make you insane by changing your gut microbiome.
-Morning sunlight reduces the length of hospitalization in bipolar disorder.
-Religious people live longer.
-Higher vitamin B1, B6 intakes and plasma pyridoxal-phosphate are associated with lower risk of mortality up to 10 years.
-NAC + Glycine has been shown to expand lifespan in mice by more than 20%.
-Taurine has been shown to expand lifespan by 10% in male mice and 12% in female ones.
-At the end of a chromosome, there are these protective caps called telomeres and the consumption of bee products showed an increase of over 0.25kbp in just a year.
-Urolithin A is more effective than most of the supplements promoted for "anti-ageing" purposes.
-Group sports extend life expectancy and being a cardio freak (marathon maxing for no reason (run a marathon 1/year if it's for charity for example) shortens it).
-B12 supports ptp-3 and helps maintain good cognitive function in centenarians.
-Biomarker differences between centenarians and diseased populations include:
1. Metallothionein
2. Good 03:06 ratio
3. Glutathione
4. SOD
5. IL-6 (low)
6. TNF-a (low)
7. Uric acid (low)
-People who die by su*cide (but also have traits such as hostility(*)) tend to have modestly lower serum total/LDL cholesterol.
But lowering cholesterol with statins does not increase suicidal behavior.
So the proposed theory for this association remains that neuroinflammation changes lipid metabolism and results in these lower circulating cholesterol levels.
(*) patients with borderline personality disorder often have lower baseline fasting serum cholesterol levels compared to patients with other personality disorders.
-Eating breakfast is linked to lower suic*de rates
-A meatless diet increases the frequency of depressive episodes.
-When doctors say that depression is caused by low serotonin, they probably mean that it's caused by high quinolinic acid (its production outpaces its clearance, to be exact).
-Autism spectrum disorder seems to be the outcome of mitochondrial dysfunction during neurodevelopment.
-Magnesium intake is inversely associated with coronary artery calcification, with the risk being lowest at 450 mg/d of magnesium.
-Green tea enhances the skin anti-aging effects of red light.
-Giving hospitalized COVID-19 patients 30,000 IU of vitamin D daily for 3 days reduced their risk of death by 67%.
-Taking ibuprofen for more than 60 days in a year makes men twice as likely to experience infertility.
-66.5% of bankruptcies in the US are due to medical bills.
-Mold exposure can lower the IQ of children by 10 points.
-Vitamin D deficiency is linked to 60% higher odds of depression.
-Nattokinase can reverse carotid artery plaque by 36% at 10,800FU (taken over a year).
-Bright night light exposure is independently associated with type 2 diabetes.
-SSRIs can suppress melatonin by almost 50% under normal light conditions.
-Extending sleep by just 1.2 hours "offsets" 300 extra calories.
-The more you increase sodium fluoride, the dumber kids become.
-Exercise (aerobic) is more effective than SSRIS.
-It might sound weird, but onion juice is actually effective for alopecia aerata.
-Exercising 4 hours after reading something improves retention.
-Creatine is an underrated supplement for lowering triglycerides.
-Negative air ions (think being outside in nature) reduce depression by 50%.
-Thinking that depression is a response to inflammation might be correct in a lot of cases.
-By taking 600mg of NAC twice a day during flu season you might drop your chances of getting sick by up to 50% (note, NAC taken for weeks on end will deplete copper and harm some of the biofilms of beneficial gut bacteria)
-240mg twice daily of Fernblock may reduce the risk of sunburn by 400% and UV damage by over 300%.
-Bile treatment improves psoriasis.
-Using a smartphone for 60 minutes a day lowers fertility and testosterone quite a lot.
-Vapes can contain up to 20 times more lead than cigarettes.
-Laughter reduces cortisol levels by up to 37%.
-Vitamin K is associated with a reduced risk of cardiovascular, cancer, or all-cause mortality.
-Gingerol and shogaol in ginger enhance insulin sensitivity by increasing GLUT4 expression and inhibiting intestinal glucose absorption.
-Chromium enhances insulin receptor activity by improving the binding of insulin to its receptors and supporting glucose metabolism.
-Myo-inositol acts as a second messenger in insulin signaling pathways, improving insulin receptor function and glucose uptake.
-Fiber reduces postprandial glucose spikes.
-Fasting induces FGF21.
-93% of chronic fatigue syndrome patients had mycotoxins in their urine.
-Glyphosate was found in the sperm of 60% of infertile men in France (in the US a bit over 80% of the population have traces in their bodies).
-About 90% of people with fibromyalgia show elevated levels of mold-related toxins in their blood or urine.
-A higher 4-PA/PLP ratio (the marker of vitamin B6 turnover/catabolism) might be one of the strongest independent predictors of all-cause mortality in type 2 diabetics.
-One hour of chopping wood (with an axe) raises salivary testosterone by 48.6%.
-Two quite underrated yet effective tools when it comes to dealing with a candida overgrowth are undecylenic acid and baicalein.
-Tyrosine hydroxylase (the enzyme that converts tyrosine) can't function properly without thiamine pyrophosphate (TPP) as a cofactor.
-Lactoferrin (apolactoferrin might be even more powerful) helps against Covid quite a lot and is an underatted tool for lowering VC.
-630+808nm of RLT 2x/week for 6 weeks reduced abdominal fat by 4-5 cm in all participants without diet or exercise in a study.
-Quercetin and EGCG are zinc ionophores (they facilitate the transport of zinc into cells).
Hydroxychloroquine and ivermectin are also promoted that are zinc inophones in the alternative health spaces but that's not true.
-Giving 300mg of CoQ10 in fibromyalgia patients for 40 days led to 53% decrease in total symptom score.
-Taurine enhances IRS-1 tyrosine phosphorylation and reduces serine phosphorylation.
-Cold exposure activates BAT, which increases glucose uptake and fatty acid oxidation.
-A 25-year study of nearly 30,000 Swedish women found that avoiding sun exposure was a major risk factor for all-cause mortality (similar in magnitude to smoking). -The first time skin cancer was induced in mice was with a lamp that emitted UVC.
-Testosterone increases punishment of unfair behavior.
-Low creatine in the prefrontal cortex is associated with depression.
-A zinc deficiency does in fact harm androgens quite a lot.
-EGCG before doing cardio improves IR sensitivity by activating AMPK and reducing oxidative stress, promoting GLUT4 translocation.
-HIIT increases GLUT4 translocation.
-Light walking (15 minutes) after meals enhances GLUT4 translocation and glucose uptake in skeletal muscle, independent of insulin.
-Hypothyroidism impairs the activation and retention of riboflavin (and maybe iron, vitamin B12, folate, vitamin D, magnesium and copper as well).
*Thyroid hormones are necessary to regulate the enzymatic conversion of riboflavin (vitamin B2) into its active coenzyme forms: flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD).
That's it.
I ran out of space.
For more: fitandball.gumroad.com/l/bra…
8ème merveille retweeted
Fun fact: if Gemini 4 Carbon would have been released yesterday, it would not have been #1 on Artificial Analysis.
On AA v4.3.2, it scores 57 against Opus 5.5 58. On v5, it scores 59 compared to Opus 5.5 58.
Conspicuous timing? :)
8ème merveille retweeted
I hate this pattern of DeepMind announcing things that are weeks out from anyone being able to actually use. Fable 5.5 will beat you to it and be a better model, and you deserve that if you’re going to do things like this!
8ème merveille retweeted
Introducing Gemini 4 Carbon, it's a big jump over Argon which we released just 2 weeks ago.
Gemini 4 Carbon is SOTA on cyber, long horizon tasks, ranks #1 on Artificial Analysis V5, significantly improves on usability in domains like coding, and is more aligned.
8ème merveille retweeted
I did say we'd be releasing our models periodically...introducing Gemini 4 Carbon, our next frontier model.
Following Argon's release just two weeks ago, Carbon shows the pace at which we’re pushing the frontier, it ranks #1 on the recently updated v5.0 of @ArtificialAnlys Intelligence Index at 59. It also leads across key cybersecurity evaluations scoring 88.2% on SEC-bench Pro for finding vulnerabilities, 54.8% on ExploitGym for exploitation, and 71.0% on CWE-bench for patching.
We’re seeing significant improvements in long-horizon tasks even compared to Argon, and we’ve strengthened frontier safeguards.
As we did with Argon, we’re going to roll it out gradually + responsibly. Some trusted cyber defenders will get access starting this week. We'll be expanding it to more partners through our Fairwind Program, ahead of wider availability soon, so hang tight!
8ème merveille retweeted
new benchmark just dropped
cognition just announced frontier code 2.0 and this has to the least benchmaxxed benchmark available right now
but why is everyone updating their benchmarks?
we know that anthropic partners already got access to fable 5.5
and i feel like after testing fable 5.5 it topped all benchmarks that teams had to update their own benchmarks lmaoo
Introducing FrontierCode 2.0: our new coding benchmark that measures a model’s ability to go beyond the spec.
Most coding evals measure a model’s ability to write code that meets a spec. With FrontierCode 1.0, we asked a new question: would you actually merge the PR?
FrontierCode 2.0 is comprised of more diverse tasks, featuring larger scopes and higher mergeability standards. We are now asking: not only would you merge this PR, but should you?
One key feature of FrontierCode 2.0 is underspecified prompts. Rather than including every engineering decision, prompts are deliberately ambiguous, giving the models room to demonstrate their judgment.
The result is a benchmark that is far from saturated, with the top model scoring just 45%.
8ème merveille retweeted
lower resting heart rate -> better sleep
deeper sleep -> more energy
higher energy -> exercise
workouts -> eating well
good nutrition -> lower resting heart rate
