Eric R. Greene (@EricRGreene1) profile picture

Eric R. Greene

@EricRGreene1

Asst. Prof. @SFSU. postdoc @fraser_lab; PhD @UCBerkeley @AndyMartinLab; teaching how to take pictures of proteins. (he/him)

Joined December 2019
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Photo by Eric R. Greene (@EricRGreene1)
Exciting work from @proteins_emma! Methods for high throughput discovery of fluoroprobes that recognize tau fibril polymorphs biorxiv.org/content/10.1101/…
Methods for high throughput discovery of fluoroprobes that recognize tau fibril polymorphs

Methods for high throughput discovery of fluoroprobes that recognize tau fibril polymorphs

Aggregation of microtubule-associated protein tau (MAPT/tau) into conformationally distinct fibrils underpins neurodegenerative tauopathies. Fluorescent probes (fluoroprobes), such as thioflavin T...

biorxiv.org
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Eric R. Greene retweeted
Emma Carroll (@proteins_emma) profile picture
Emma Carroll@proteins_emma23 Jul 2023
Overjoyed to share that I am starting as a tenure-track Assistant Professor of Chemistry @SJSU!
Image from Emma Carroll (@proteins_emma)
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I’m excited to announce that I’ll be starting as a tenure-track Assistant Professor in the Department of Chemistry and Biochemistry @SFSU this fall!
Image from Eric R. Greene (@EricRGreene1)
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My lab will focus on applying #cryoEM and enzymology approaches towards open questions about enzyme function and regulation in human health and disease. I’m excited to be able to teach science like how we do science and provide a training platform for students to learn #cryoEM.
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I’m grateful to my mentors for their continued support @fraser_lab @AndyMartinLab @MarquseeLab, to my students for teaching me how to be an effective mentor, and to @SLAClab and their S2C2 facility for microscope training and data!
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I am excited to announce I've accepted a job offer at @UCSF @UCSF_BTS @QBI_UCSF where I will be starting as an Assistant Professor in July 2023! We are hiring at all levels including specialist, grad students, and postdocs. Join us: wcoyotelab.com (1)
Image from Willow Coyote-Maestas (@willowcoyote)
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A new study from @thisismadani, @nikhil_ai, @fraser_lab, and colleagues describe a deep-learning language model that learns “grammatical” rules to write novel protein sequences with defined functions. @chang_c_liu liebertpub.com/doi/10.1089/g…
Image from GEN Biotechnology (@GENBiotechJrnl)
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Eric R. Greene retweeted
Ali Madani (@thisismadani) profile picture
Ali Madani
@thisismadani26 Jan 2023
ChatGPT for biology? Excited to share our work on LLMs for protein design out today @NatureBiotech nature.com/articles/s41587-0… + Proud to publicly announce @ProfluentBio with a $9M seed round to tackle meaningful challenges in biology with AI. Join us!
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Nikhil Naik (@nikhil_ai) profile picture
Nikhil Naik
@nikhil_ai26 Jan 2023
Excited to have our paper on using large language models like ChatGPT for protein design come out in @NatureBiotech! You can tell a language model which type of protein to design, and it can generate one from scratch! nature.com/articles/s41587-0…
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Ranabir Das (@RanabirNMR) profile picture
Ranabir Das@RanabirNMR17 Aug 2022
Are proteasomal tags merely escorts to the proteasome? Our results with the FAT10 proteasomal tag shows that it also modulates substrate stability to accelerate degradation biorxiv.org/content/10.1101/…
The proteasomal degradation signal FAT10 modulates substrate stability to accelerate proteasomal...

The proteasomal degradation signal FAT10 modulates substrate stability to accelerate proteasomal...

The proteasome machinery regulates the levels of most cellular proteins. However, the factors determining rate of proteasomal degradation remain poorly understood. A rate-limiting step of degradation...

biorxiv.org
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Eric R. Greene retweeted
Emma Carroll (@proteins_emma) profile picture
Emma Carroll@proteins_emma29 Jul 2022
So excited to share that the preprint for a small piece of my postdoc work is out today! biorxiv.org/content/10.1101/…
The Chemical Features of Polyanions Modulate Tau Aggregation and Conformational States

The Chemical Features of Polyanions Modulate Tau Aggregation and Conformational States

The aggregation of tau into insoluble fibrils is a defining feature of neurodegenerative tauopathies. However, tau has a positive overall charge and is highly soluble; so polyanions, such as heparin,...

biorxiv.org
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Our 1st manuscript on DIMPLE from @ucsf @QBI_UCSF and my 1st senior author! If interested in DMS, indels, high throughput assays, membrane proteins, and how we can combine these to explore protein evolution, disease, and structure function check it out! biorxiv.org/content/10.1101/…
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Such a privilege and great time presenting this work at #PS36! Thanks for the shoutout @oletaknowsstuff!
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Emma Carroll (@proteins_emma) profile picture
Emma Carroll@proteins_emma7 Mar 2022
Really enjoyed revisiting my grad work and the world of site-specific ubiquitination for my first review article! Thanks to all who helped put this together!
Marqusee Lab (@MarquseeLab) profile pictureMarqusee Lab@MarquseeLab7 Mar 2022
Check out this new review on site-specific ubiquitination from our previous grad student @proteins_emma (now a postdoc with @GestwickiLab)! sciencedirect.com/science/ar…
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Emma Carroll (@proteins_emma) profile picture
Emma Carroll@proteins_emma19 Oct 2021
Excited to share our latest preprint from the @GestwickiLab (and the first preprint of my postdoc)! Check it out! biorxiv.org/content/10.1101/…
Two distinct classes of co-chaperones compete for the EEVD motif in heat shock protein 70 (Hsp70)...

Two distinct classes of co-chaperones compete for the EEVD motif in heat shock protein 70 (Hsp70)...

Chaperones of the heat shock protein 70 (Hsp70) family engage in protein-protein interactions (PPIs) with many co-chaperones. One hotspot for co-chaperone binding is the EEVD motif that is found at...

biorxiv.org
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Eric R. Greene retweeted
Ali Madani (@thisismadani) profile picture
Ali Madani
@thisismadani19 Jul 2021
This twirling work of science is special ✨ AFAIK, it's the first crystal structure of a functional #protein fully designed by #AI A milestone in our quest to use language models to generate proteins that are unseen in nature & can function well in the real-world. Read below👇
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Debora Marks (@deboramarks) profile picture
Debora Marks
@deboramarks19 Jul 2021
Fabulous - and tested - more than wishful thinking. Now - what shall we design ?
Ali Madani (@thisismadani) profile pictureAli Madani
@thisismadani19 Jul 2021
This twirling work of science is special ✨ AFAIK, it's the first crystal structure of a functional #protein fully designed by #AI A milestone in our quest to use language models to generate proteins that are unseen in nature & can function well in the real-world. Read below👇
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Thrilled to announce my first preprint as a postdoc, an exciting interdisciplinary effort led by @SFResearch in collaboration with @tierrabio and @fraser_lab utilizing language-based #AI to generate function proteins! doi.org/10.1101/2021.07.18.4…
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Great summaries of the work can be found here xitter.gq/nikhil_ai/status/14132…, xitter.gq/thisismadani/status/14…, xitter.gq/fraser_lab/status/1417…. I contributed in vitro biochemistry and a biology-centric perspective to the project.
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It was a pleasure working directly with @nikhil_ai @thisismadani @benwkrause @joseluisolmosjr, Ben Mohr, ZacharySun, and James Holton. I am excited to continue pushing the boundaries in this space towards making designer proteins!
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