@FelthamLab

We smash & trash; we #PROTAC and attac 💣 We discover new drug targets & hijack the #ubiquitin system to remove them💊 Tweets by PI @BekkyFeltham @WEHI_research

 Melbourne, Victoria
Joined November 2019
  • Tweets117
  • Following80
  • Followers407
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Excited to finally share our new paper, now out in Heliyon: ANCHR regulates TRAIL-mediated apoptosis with implications for liver injury Read it here: authors.elsevier.com/sd/arti… #Apoptosis #TRAIL #LiverInjury #UbiquitinBiology #MIB2 #ANCHR @WEHI_research
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Thrilled to share our new paper out in Nature Communications 🎉 We benchmark tag-degraders in vivo! Huge congratulations to @CharleneMagtoto and the whole team. nature.com/articles/s41467-0… @WEHI_research #TPD, #Drugdiscovery

The benchmarking and application of tag-degraders in vivo to validate therapeutic targets

Nature Communications - Targeted protein degradation offers a way to test drug targets before costly drug development begins. Here, the authors benchmark tag-degrader systems in mice, identify dTAG...

nature.com
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Proud to share The E3-ome A true collaborative effort to unify the human E3 ligase landscape, and create a shared foundation for the field #Ubiquitin #E3Ligases @WEHI_research cell.com/cell/fulltext/S0092…

The E3-ome gene-centric compendium reveals the human E3 ligase landscape

The E3-ome defines the human repertoire of ubiquitin E3 ligases, creating a unified resource that maps their diversity across the ubiquitin and ubiquitin-like systems. By consolidating fragmented...

cell.com
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Heads up for those working in ubiquitin biology and targeted protein degradation—Lorne Ubiquitin 2025 is happening 20–23 November in Lorne, Victoria, Australia. Late abstracts are still being accepted—worth checking out!!! 🦘🦘🦘
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Had an exciting morning of #TargetedProteinDegradation at the launch of Ternarx! @ternarx49306 Fantastic to have strong support from @Mark_Butler_MP and the incredible team @WEHI_research. 🔗 Explore our journey and vision: [WEHI Announcement](wehi.edu.au/news/wehi-spinou…)

WEHI spinout company set to revolutionise homegrown cancer treatments

Australia has cemented its role in becoming a major player in the next-generation of medicines with the launch of Ternarx

wehi.edu.au
WEHI (Walter and Eliza Hall Institute)@WEHI_research18 Jun 2024
Replying to @WEHI_research
Ternarx is the first biotech company of its kind in Aus. focused on developing targeted #proteindegrader medicines for hard to treat #cancers. A great partnership with WEHI, @MonashUni & @KidsCancerInst, backed by $15m in #MRFF @healthgovau funding. wehi.edu.au/news/wehi-spinou… 🧵2/2

WEHI spinout company set to revolutionise homegrown cancer treatments

Australia has cemented its role in becoming a major player in the next-generation of medicines with the launch of Ternarx

wehi.edu.au
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Excited to be part of the CeTPD scientific opening #TPDFocus @dundeeuni
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🔬2024 Lab Update! 🌟 Farewell to incredible team members, @DanielSimpsonAU and Anna Gabrielyan. Wishing them success as postdocs!💙Excited for new faces and opportunities in 2024. Here's to innovation, collaboration and new discoveries🚀 #LabLife #NewBeginnings #Science2024
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Unlocking the secrets of the E3 ligase MIB2!🕵🏻‍♂️ Our new paper @PNASNexus unravels the mysteries of MIB2 in mice with the cpd mutation, and its unexpected role in wound healing 🐁🩹 An excellent study we're thrilled to share!#wehiresearch #MIB2Discovery academic.oup.com/pnasnexus/a… – at Melbourne, Victoria

Mind bomb 2 limits inflammatory dermatitis in Sharpin mutant mice independently of cell death

Abstract. Skin inflammation is a complex process implicated in various dermatological disorders. The chronic proliferative dermatitis (cpd) phenotype drive

academic.oup.com
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Abstract submissions for 2024 @LorneProteins, incl. the Satellite Meeting on "Ubiquitin signalling: Molecular mechanisms, biology and targeted protein degradation" are closing soon. If you work on #ubiquitin, ubiquitin-like modifiers, #PROTACs or #TPD, we want to hear from you!
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Great talk from @mediocre_jake today talking all things E3 ligase, a favourite topic in the @FelthamLab @WEHI_research
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