Twitter account of the Fiedler group. (student handled)
Berlin, Germany
Joined August 2020
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We would also like to thank all the people involved in this study. @MRuwolt @theliulab @JeremyAMMorgan
To substantiate our findings, we collaborated with @PhosphorusFive @CEStieger and @daniel_roderer @FelixSchoepf to obtain mass spectrometry spectra and the first-ever Cryo-EM structure of pyro-and oligo- phosphorylated proteins.
Our research revealed that the metastasis suppressor protein NME1, previously identified as pyrophosphorylated by Morgan et al. 2024, contains an oligophosphorylated amino acid residue in mammalian cell lines.
During our investigation of protein pyrophosphorylation, we identified a novel post-translational modification (PTM), which we have termed 'Protein Oligophosphorylation'.
biorxiv.org/content/10.1101/…
science.org/content/blog-pos…
Pyrophosphorylation „In the Pipeline“ :)
On the way to understanding the role of pyrophosphorylation, he also discovered a new mode of protein pyrophosphorylation! Thank you Arif for the hard work!
Follow up to our discovery of endogenous protein pyrophosphorylation, Arif Celik, a PhD student from our lab, decided to select one of the newly found „pyrophosohoproteins“ and see what effect does this PTM have on protein activity.
pubs.acs.org/doi/10.1021/jac…
Together with the paper checkout this „News&Views“ article about the „Pyrophosphomania“!
nature.com/articles/s41589-0…
Happy to share our latest paper on protein pyrophosphorylation - yes, it exists! It has been a long journey with many wonderful co-workers and collaborators. Thank you all!
@JeremyAMMorgan @MRuwolt
nature.com/articles/s41589-0…
Fiedlerlab retweeted
📢Vortrag: Wer quasselt da? Wie Zellkommunikation funktioniert, Prof. Dr. Dorothea Fiedler @FiedlerLab
Für Lehrkräfte, Schüler:innen & Wissbegierige
📍 Kinosaal des Zeiss-Großplanetariums,Berlin
🕓16 Uhr, 7. Nov. Eintritt: Kostenlos!
📝 [email protected]
#BerlinSciWeek
After a lot of efforts from our former post doc Sarah Hostachy, we are do happy to see this out!
Fluorination Influences the Bioisostery of Myo-Inositol Pyrophosphate Analogs (Dorothea Fiedler and co-workers) @FiedlerLab @LeibnizFMP onlinelibrary.wiley.com/doi/…
Unexpected results often lead to fascinating discoveries!
Have a look at this new paper from our lab where @timaguirre_chem developed an inhibitor for IP6Ks and found out some really cool mechanistic details about the inhibition
elifesciences.org/articles/8…
Fiedlerlab retweeted
📢Exciting talk alert! Maja Köhn @MAJAFL @UniFreiburg will delve into "Function, selectivity & chemical targeting of protein phosphatases.”
This Friday, September 29th, 3:00 pm. Join us on Zoom! Meeting-ID: 963 0761 9443, Kenncode: 550079
#ScienceTalk @PhosphorusFive @FiedlerLab
Fiedlerlab retweeted
Congratulations to Minh Nguyen Trung @FiedlerLab for a wonderful defense of his PhD "Elucidation of Inositol Polyphosphate Dephosphorylation Pathways using Stable-Isotope Labelling and NMR spectroscopy" What a journey! Grateful to have been part of the evaluation committee🍾🥞😀
