Cardiorenal Epidemiologist @georgeinstitute via @Oxford_NDPH | HDR UK-Turing Wellcome PhD candidate @Cambridge_Uni | SMART-C Analytics Lead https://xitter.gq/t.co/ukfYbdLxgW | #COYS
Sydney, New South Wales
Joined April 2011
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- Following131
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Robert Fletcher retweeted
Can treatment for type 2 diabetes & chronic kidney disease reduce greenhouse gas emissions? 🌱
@Fletcher_RA & colleagues found increased use of SGLT2 inhibitors in people with diabetes & CKD reduced greenhouse gas emissions by 20%
Read the paper here: tinyurl.com/ee9ytwrr
ALT An image summarising the research work. Diabetes affects over 500 million people and can have huge impact on health. The developments of diabetes complications can increase carbon emissions. Using data from the Credence trial researchers found a reduction in greenhouse gas emissions of 20%.
Robert Fletcher retweeted
Prevent kidney failure to reduce carbon emissions ♻️ 🍃 🏭
Our new analysis of CREDENCE assessing environmental impacts from ⬇️ hospitalisations & dialysis 🏥 with SGLT2i
⬇️ emissions from inpatient bed days & dialysis by 20% (39 kg CO2e per yr)
thelancet.com/journals/lanpl…
Robert Fletcher retweeted
CKD arguably the most consequential common comorbidity in heart failure, accounting for >2x rehospitalisations than any other condition
UK data from almost 1/4 million people, now open access online in @LancetGH, from @Fletcher_RA and our team: thelancet.com/journals/lanpu…
Whole pop UK linked data on >230,000 ppl with HF from @Fletcher_RA at #ESCCongress
- Ppl with CKD remain undertreated for HF despite being at 🔼 risk
- CKD contributes 2x to 🏥/☠️ than any other comorbidity
- Major opportunities to improve pop health
In press, @TheLancetPH
Robert Fletcher retweeted
“Out of doubt, out of dark, to the day's rising
he rode singing in the sun, sword unsheathing.
Hope he rekindled, and in hope he ended;
over death, over dread, over doom lifted
out of loss, out of life, unto long glory.”
Robert Fletcher retweeted
Yes, however the study was not powered to find a difference of eGFR slope.
Like to mention that I validated the eGFR slope calculation using the fantastic github repository of @Fletcher_RA and @brendonneuen
github.com/SGLT2-Trialists-C…
#NephJC
Robert Fletcher retweeted
#Meat consumption and incident type 2 #diabetes: an individual-participant federated meta-analysis of 1·97 million adults with 100 000 incident cases from 31 cohorts in 20 countries thelancet.com/journals/landi… #T2D
#OpenAccess
Robert Fletcher retweeted
Whole pop UK linked data on >230,000 ppl with HF from @Fletcher_RA at #ESCCongress
- Ppl with CKD remain undertreated for HF despite being at 🔼 risk
- CKD contributes 2x to 🏥/☠️ than any other comorbidity
- Major opportunities to improve pop health
In press, @TheLancetPH
Robert Fletcher retweeted
🔥 A new therapeutic era in #HFpEF
#FINEARTSHF with definitive evidence supporting the role of the non-steroidal MRA finerenone at #ESCCongress
Now in @NEJM
nejm.org/doi/full/10.1056/NE…
Robert Fletcher retweeted
In addition to the late-breaking FINEHEART finerenone pooled IPD data in HFpEF & CKD from @mvaduganathan in HOTLINE 7, join us for multiple kidney-related presentations at #ESCCongress
Kidney data from DELIVER, PARAGON, TOPCAT, I-PRESERVE, CANVAS & CREDENCE trials & much more
Robert Fletcher retweeted
Important new data on the potential for loop diuretic intensification as a surrogate outcome for worsening HF - for the first time, examined in people with kidney disease!
@safchat presenting these data at 9:30AM on Sept 1
Look forward to sharing kidney data at #ESCCongress
Critical issue in #SUMMIT will be the use of a novel expansion of “worsening HF” definition to incl oral diuretic intensification w traditional components CVd, HF hosp, & urgent HF visits
No regulatory precedent…yet.
Data in keeping with #STEPHFpEF findings on this endpoint
Robert Fletcher retweeted
The George Institute commends ANZ Food Ministers for actioning a significant package of food labelling reforms today.
The decision to start the work needed to support Health Star Ratings being mandatory if targets are not met by 2025 is a positive step.
bit.ly/4cSsgxH
Robert Fletcher retweeted
'The way we are interpreting this is, it is very likely to provide additive protection.'
@brendonneuen talks to @marywardy @smh about the heart and kidney benefits of combining two diabetes drugs.
@HeerspinkHiddo @VladoPerkovic @Fletcher_RA
bit.ly/3S81M3b
Robert Fletcher retweeted
Labelling systems like the Health Star Ratings need to continually evolve to reflect nutrition science - our researchers showed how modifying the algorithm can address the issue of high scores on unhealthy items.
Read more: georgeinstitute.org.au/media…
Robert Fletcher retweeted
Transcriptomic analyses suggest NK cells play an important role in AMR, but immunohistologic studies on NK cell infiltrates in rejecting allografts are scarce.
Happy to share our latest analysis addressing this gap.
frontierspartnerships.org/ar…
Robert Fletcher retweeted
Our condolences to the friends, colleagues, and family of George L Bakris, MD.
Dr Bakris was a giant in the world of diabetes, hypertension, metabolic disease.
Robert Fletcher retweeted
If you’re tired of thinking about the election, why not take a brain bath and think about medieval history? Here’s a video about Sutton Hoo, and a simpler time when our leaders got buried in their favourite boats. It is available with an accompanying book: shor.by/UNRULY