Takashi Fukaya (@FukayaLab) header
Takashi Fukaya (@FukayaLab) profile picture

Takashi Fukaya

@FukayaLab

Institute for Quantitative Biosciences, UTokyo. We study the mechanism of transcriptional regulation in the Drosophila embryo.

 Tokyo-to, Japan
sites.google.com/view/fukaya-lab-iqb/home
Joined September 2019
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Photo by Takashi Fukaya (@FukayaLab)Photo by Takashi Fukaya (@FukayaLab)Photo by Takashi Fukaya (@FukayaLab)Photo by Takashi Fukaya (@FukayaLab)Photo by Takashi Fukaya (@FukayaLab)Photo by Takashi Fukaya (@FukayaLab)Photo by Takashi Fukaya (@FukayaLab)Photo by Takashi Fukaya (@FukayaLab)Photo by Takashi Fukaya (@FukayaLab)Photo by Takashi Fukaya (@FukayaLab)
How do distal enhancers control transcription dynamics in living cells? Check out our latest work published in @MolecularCell!! We show that the dynamic assembly and disassembly of TF clusters at enhancers are a major source of transcriptional bursting. cell.com/molecular-cell/full…
Image from Takashi Fukaya (@FukayaLab)
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Kazuhiro Maeshima (@kazu_maeshima) profile picture
Kazuhiro Maeshima@kazu_maeshimaOct 30
Our new paper @CellReports, led by @katsu_s_minami et al.! 🎉🧬🔬 cell.com/cell-reports/fullte… Machine learning-assisted Repli-Histo labeling and single-nucleosome imaging reveal distinct transcription-dependent chromatin constraints across euchromatin and heterochromatin. Congrats!
Image from Kazuhiro Maeshima (@kazu_maeshima)
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youtube.com/watch?v=Ned8A1DX…
Cornelius "Mirrors" (Live at Zepp Shinjuku/Oct. 6th, 2026) | 5-Camera Fixed-Angle Footage

Cornelius "Mirrors" (Live at Zepp Shinjuku/Oct. 6th, 2026) | 5-Camera Fixed-Angle Footage

CORNELIUS REFRACTIONS NORTH AMERICA TOUR 202725 March — Philadelp...

youtube.com
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Frank Noe (@FrankNoeBerlin) profile picture
Frank Noe@FrankNoeBerlinOct 20
Public preview of BioEmu2! @MSFTResearch AI for Science’s new foundation model for biomolecular structure, dynamics and function. Open weights, MIT license. github.com/microsoft/bioemu2 Movie: BioEmu2-simulated binding of intrinsically disordered peptide PUMA to MCL-1 receptor. 🧵⬇️
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ISHIGURO Lab (@IshiguroL) profile picture
ISHIGURO Lab@IshiguroLOct 29
Our study on OMC1 is now published in Nature Aging! We discovered an oocyte-specific protein that helps maintain chromosome cohesion throughout reproductive life. doi.org/10.1038/s43587-026-0…
Image from ISHIGURO Lab (@IshiguroL)
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Tadasu Nozaki (@tadasu443) profile picture
Tadasu Nozaki@tadasu443Oct 28
The Nozaki Lab at UMass Amherst is recruiting graduate students! We study chromosome dynamics and meiosis using live-cell imaging. Apply through MCB or Plant Biology. Both programs welcome! Any questions? Feel free to DM me. nozakilab.org/ #Chromosome #Meiosis #Imaging
The Nozaki Lab | Nozaki Lab @ UMass Amherst

The Nozaki Lab | Nozaki Lab @ UMass Amherst

Chromosomes as living information media

nozakilab.org
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minja (@minjaf) profile picture
minja@minjafOct 26
1/12 CTCF has updated its LinkedIn again! Our preprint tracks CTCF's “career” across Bilateria. From DNA-binding to transcription regulation & genome architecture. Read it: biorxiv.org/content/10.64898… And back-to-back work from Darío Lupiáñez's group: biorxiv.org/content/10.64898… vvv
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羊土社より出版された理系総合のための生命科学第6版、４章「遺伝子の発現1」を担当しました。セントラルグマの記載について、1957年のCrickによるオリジナルの定義に従い、「配列情報の一方向性」を示すものとして改訂を行いました。 yodosha.co.jp/yodobook/book/…
Image from Takashi Fukaya (@FukayaLab)
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いわゆる「DNA>RNA>Protein」は後年、Watsonが1965年出版のMolecular Biology of the Geneにおいて単純化して記載したものであり、オリジナルの定義とは異なる(こちらが一般に普及し、高校教科にもそのように記載されるに至った)
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nature.com/articles/227561a0

Central Dogma of Molecular Biology

Nature - Central Dogma of Molecular Biology

nature.com
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Cell Press (@CellPressNews) profile picture
Cell Press@CellPressNewsOct 23
Integration by parts: the multi-layered mechanisms of cis-regulatory control. Check out this review by @jake_cs_ @briscoejames & @joadelas in @molecularcell #ASHG26 hubs.ly/Q04BHsSC0
Integration by parts: The multi-layered mechanisms of cis-regulatory control

Integration by parts: The multi-layered mechanisms of cis-regulatory control

Cornwall-Scoones et al. discuss a two-layer model of cis-regulatory computation. Binding-level integration classifies TF cooperativity along orthogonal axes of specific-general and symmetric-asymme...

cell.com
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Excited to share a preprint on the structural mechanism of transcriptional activation by human Mediator, studied using integrative structural modeling. Many thanks to Lacra Bintu @BintuLacra for helpful discussions! biorxiv.org/content/10.64898… @generegulation @MED_COMPLEX
Image from Andrey Feklistov (@AndreyFeklistov)
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Nilimesh Das (@NilimeshDa6026) profile picture
Nilimesh Das@NilimeshDa6026Oct 22
An excellent story on condensate ageing and amyloid fibril. For FUS, ageing condensates become glassy and arrested, while amyloid fibres grow mostly in the dilute phase outside them. Two distinct solid states coexist without directly interconverting.
Nature Physics (@NaturePhysics) profile pictureNature Physics@NaturePhysicsOct 21
Fibres are thought to emerge from a dense protein condensate ageing into a glassy state. It is now shown that protein fibres and glassy condensates may result from two competing ageing pathways. nature.com/articles/s41567-0…
Image from Nature Physics (@NaturePhysics)
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Olivier Borkowski (@O_Borkowski) profile picture
Olivier Borkowski@O_BorkowskiOct 22
Design of synthetic activators for programmable gene expression doi.org/10.64898/2026.10.19.…
Image from Olivier Borkowski (@O_Borkowski)
Image from Olivier Borkowski (@O_Borkowski)
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Will Chen (@wchenomics) profile picture
Will Chen@wchenomicsOct 21
biorxiv.org/content/10.64898…
Design of synthetic activators for programmable gene expression

Design of synthetic activators for programmable gene expression

Transcription factors control gene expression by recruiting transcriptional coactivators through intrinsically disordered transcriptional activation domains (TADs), whose weak and promiscuous...

biorxiv.org
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Takashi Fukaya retweeted
Will Chen (@wchenomics) profile picture
Will Chen@wchenomicsOct 21
Thrilled to share my freshly "baked" Baker lab paper. We took a bottom-up approach to designing transcriptional regulators. Instead of relying on natural activation domains, we designed compact proteins that recruit specific cofactors. Activators for now, repressors to come!
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Cell (@CellCellPress) profile picture
Cell@CellCellPressOct 21
In the latest issue! Somatic epimutations cap genetic determinism in the human diploid chromatin epigenome dlvr.​it/TW0n9C
Image from Cell (@CellCellPress)
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Nezar Abdennur (@nv1ctus) profile picture
Nezar Abdennur@nv1ctusOct 20
Ever wanted to watch chromosomes fold? lefsim simulates loop extrusion live in your browser. Add, remove and drag CTCF sites around, watch contact maps emerge, and more. lefsim.abdenlab.org
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Very sad to hear of Nori Satoh’s passing. oist.jp/news-center/news/202…
In Memoriam: Dr. Noriyuki Satoh, Professor of the OIST Marine Genomics Unit

In Memoriam: Dr. Noriyuki Satoh, Professor of the OIST Marine Genomics Unit

A scientist devoted to pursuing the mysteries of life.

oist.jp
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Takashi Fukaya retweeted
Nilimesh Das (@NilimeshDa6026) profile picture
Nilimesh Das@NilimeshDa6026Oct 18
Transcription factor specificity isn’t encoded by DNA motifs alone. Live-cell single-molecule imaging shows that unstructured transcription factor interactions enable emergent specificity. science.org/doi/10.1126/scie…
Unstructured transcription factor interactions enable emergent specificity

Unstructured transcription factor interactions enable emergent specificity

How intrinsically disordered regions (IDRs) shape chromatin binding and nuclear organization of transcription factors (TFs) remains unclear. We used proximity-assisted photoactivation (PAPA), a...

science.org
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