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Genome-Instability&Human-Pathologies

@GPathologies

Genomes are constantly exposed to damage. Failure to repair DNA lesions leads to mutations, which can contribute to neurodegeneration, aging, and cancer!

bioscienzebio.unimi.it/gruppo.php?id=25
Joined November 2019
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All the GiHP Labs and more!!! Have a wonderful summer
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Congratulations to Ali El Zein for his Master's Thesis on "Characterizing the role of nucleases in a Nucleotide Excision Repair-independent pathway in response to UV damage" @SarahSertic1981 👏👇
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The research group will work on a new gene involved in tumor development and understand the role of structural modifications of chromosomes in genomic instability and tumorigenesis.
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"Protein factors regulating genome stability at non canonical chromosomal structures in normal and cancer cells" Prof. Marco Muzi Falconi project approved by Call for proposals 2024 at AIRC Foundation #AIRC #Unimi #bioscienze_Unimi #lastatalemilano #innovation 👇👇👇
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Do you love biological research? Apply for an open position in Achille Pellicioli's lab at University of Milano, Dept. of Biosciences
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Goodbye guys @diego_rondelli @ozge @GiuliaBernini @LucaMenin, hope to keep in touch with you! 😢
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A new review from the @GPathologies group! ➡️ Summarizing all the relevant aspects of G-quadruplex biology by combining/discussing results from different works expecially cutting-edge experimental evidence. Take a look!
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Interesting seminar from Ralf Wellinger, and congratulations to @lavinia_grasso for her PhD! Wonderful presentations! and a good Pizza as well🧪🍕
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Very interesting seminar! see you soon
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Congrats to @MCDlab99 Maria Chiara Dell'Oca on defending her Master Thesis! 👏👏👏
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Great news today! Muzi-Falconi's lab is happy to share is work on Haspin and its important role during spindle orientation and tissue morphogenesis together with ARHGAP11A👏👏👏
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Guess where are they? @achille, @SamueleLodovic1 @metteo, @my_vietri !
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Plus amazing guests/committee
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Congratulations to Maria Ylenia Vietri (Mary 😊) Outstanding presentation and discussion! Good luck for your scientific future!
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Soon we will meet her!
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Well done Martina Oliva! Congratulations👏
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Congratulations to Ludovica Verzilli and saccharomyces cerevisiae!!! and of course her Tutor: Matteo Di Terlizzi
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Congratulation for this work! cell.com/cell-reports/fullte… Pellicioli's group and collaborators showed through molecular details how PARP1 inhibition leads to over-resection of Cas9-induced DSBs, through BRCA1 PARylation!
PARylation of BRCA1 limits DNA break resection through BRCA2 and EXO1

PARylation of BRCA1 limits DNA break resection through BRCA2 and EXO1

Lodovichi et al. show that BRCA1 PARylation limits excessive resection of DNA double-strand breaks (DSBs). Inhibition of PARP1 or expression of an unPARylable variant of BRCA1 leads to over-resection...

cell.com
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