Galectin-3

Did you know that Galectin-3 is: ✔️ a ß-galactoside-binding lectin? ✔️ linked to heart & kidney disease, M. Alzheimer and COVID19? ✔️well-studied:>5000 studies, ~300 in 2022? Overwhelming?@Galectin3 is your weekly update with #MechanisticMonday, #WisdomWednesday & #FridayReads!

This #fridayreads still needs peer-review but already showed some interesting concepts: targeting #Galectin3 to improve #cardiovascular disease outcomes in #obese individuals! pubmed.ncbi.nlm.nih.gov/3713…

#wednesdaywisdom Did you know that, - #Galectin3 = ⬆ in people with severe #obesity (BMI > 35 kg/m2). - individuals with severe obesity + high Galectin3 have >4x higher risk of #heartfailure (HR, 4.19; 95% CI, 2.98-5.88)? #CardioTwitter

#mechanisticmonday Improving endothelial function through #Galectin3 and NOX1? ⬆ NOX1 = ⬆ oxidative stress + endothelial dysfunction. Galectin3 increases NOX1 promotor activity. In obesity ⬆ NOX1, but NOX1 levels are normal in obese Galectin3 KO mice! #obesity #Science

This hypothesis-generating #fridayreads combines obstructive sleep apnea (OSA), atrial fibrillation and fibrosis. Of course the pro-fibrotic biomarker #Galectin3 was measured. My #QuestionOfTheDay: does OSA cause fibrosis, or does fibrosis cause OSA?🐔🥚 pubmed.ncbi.nlm.nih.gov/3711…

#wednesdaywisdom #Galectin3 levels are higher in patients with obstructive sleep apnea. But did you know that 3-month CPAP treatment lowers Galectin-3 up to 1.5 times and improves left ventricle global longitudinal and left atrial reservoir function? #cardiotwitter #echofirst

#mechanisticmonday cardiac #fibrosis is a common problem in patients with obstructive sleep apnea (OSA), and these patients have up to 60% more fibrosis than patients without OSA. #galectin3 is also higher in these patients, and so are NTproBNP, IL6 and CRP! #cardiotwitter

This manuscript on ProLectin-M (PL-M), a Gal-3 antagonist, was brought to my attention by one of our followers. What do you think of it?! @VirusesImmunity @CarolynBertozzi #fridayreads mdpi.com/2214570 #mdpivaccines

#wednesdaywisdom #Galectin3 may be one of the reasons why #COVID19 is so infectious and tranmissible. How? Because of high Galectin3 in human nasopharynx and oral mucosa + strong interaction with protein molecules. #science #CovidIsNotOver

After 2 years of the #COVID pandemic we're still learning about this disease. #mechanisticmonday: 1. #Galectin3 binding domain (galactose) = almost identical to that of SARS-CoV2 2. Gal3 receptors = strong interaction with SARS-CoV2 spike proteins through COOH terminal.

Always wondered how #Galectin3 is exactly involved in cancer metastasis? This is a great work on how #invitro studies help us to better understand disease mechanisms. Enjoy! @SpringerNature @sciencetwitter ncbi.nlm.nih.gov/pmc/article…

#wisdomwednesday Healthy humans have > 900 protease that are low in amount and tightly controlled. In cancer, proteases are overexpressed and cause tumour cell invasion + spreading. #Galectin3 mediates protease secretion and is thus directly involved in #Cancer progression!

In human colon cancer cells #Galectin3 causes release of proteases (e.g. cathepsin-B, MMP-1, MMP-13) that induce PYK2-GSK3α/β signalling. Result? Disrupted epithelial monolayer integrity, increased permeability and more tumour cell invasion. #mechanisticmonday #coloncancer

This #fridayreads is about #Galectin3 and its role in gut health. This work is an elegant example how cleavage of Galectin3 by α/β heterodimers may play a key role in colon host-microbiome homeostasis. #Galectin3 for good #gutfeeling? #sciencetwitter pubmed.ncbi.nlm.nih.gov/3700…

To date, no biomarkers exist to diagnose Intestinal Bowel Disease (#IBD). Can #Galectin3 help? Potentially, as it is ⬆ in IBD patients. Galectin3 >38.5 ng/ml? = 53% sensitivity + 87% specificity IBD. Unfortunately, it cannot distinguish active vs remission. @CrohnsColitisC3

#mechanisticmonday #HappyEaster #Galectin3 is the major intestinal substrate for meprin alpha/beta heterodimers. These meprins from a unique enzyme complex in gut to ensure happy colon host-microbiome homeostasis #gutfeeling @IBDjournalclub

This manuscript for #fridayreads is a good example how biomarkers and cardiac MRI can be used to assess adverse outcomes in HF patients. Important? Yes, since it may ultimately improve prognosis in HF patients #imaging #biomarkers @escardio pubmed.ncbi.nlm.nih.gov/3697…

#wisdomwednesday Cardiac MRI (CMR) visualizes myocardial fibrosis. It, however, may not always see all fibrosis. Therefore, using plasma biomarkers such as #Galectin3 may help to reduce sudden cardiac death in heart failure patients as they improve risk classification by 11%!

#mechanisticmonday #Galectin3 and Cardiac MRI - how would that work? Late gadolinium contrast (LGE) on cardiac MRI is associated with more fibrosis. Interestingly, LGE on MRI and short T1 = higher Galectin3 and higher risk of adverse events. #cardiacmri #biomarkers

In this #fridayreads the relationship between #HFpEF and #Galectin3 is shown in more detail. The authors conclude that #Galectin3 may represent a novel HFpEF #biomarker and #therapeutic. #QuestionOfTheDay: do you agree? @escardio @ACCinTouch pubmed.ncbi.nlm.nih.gov/3695…

#wednesdaywisdom Did you know that #Galectin3 helps to diagnose #HFpEF, while it may also predicts #prognosis? Its role, however, may not be straightforward and high-risk patients with multiple comorbidities may benefit more than others. #sciencetwitter @HeartFailureFrm