Excited to partner with @GenScript to launch the Beyond Binding Challenge! 🧬 AI-designed antibodies need to go beyond binding affinity to become real therapeutics. Let's push the boundaries of AI-driven antibody design and turn computational breakthroughs into real-world impact. Up to $2.5M in awards. Stay tuned!

What does an AI-native workflow for protein binder design look like in practice? In our latest post, we walk through a pilot design run using NovaDDE: Given a target, the AI agent analyzes the design problem, helps select an epitope and design approach, submits the job, and guides the computational evaluation of the resulting candidates. We also share some of the directions we’re exploring as we continue to develop the workflow. A closer look at NovaDDE and where we’re taking it next: geodesiclab.com/news/novadde…

Today, we’re launching the Geodesic API Platform. geodesiclab.com/api For the first time, Geodesic is making our AI models and drug discovery capabilities available through APIs. At its core is NovaAtom, our in-house model for predicting the structures of proteins, small molecules, nucleic acids, and their interactions. Now available in Lite Preview, this is the first time NovaAtom has been made available beyond Geodesic’s own discovery platform. Alongside NovaAtom, we’ve integrated the field’s core models — carefully curated and continuously updated. To use the API: curl -X POST platform.geodesiclab.com/api… \ -H "Authorization: Bearer $GEODESIC_API_KEY" \ -F "model=novaatom" \ -F 'params={"jobName":"rbd-nanobody","sequences":">rbd\nTNLCPFGEVFNATRFASV...\n>nb\nQVQLVESGGGLVQAGGSLR..."}' Poll the job, pull the results, and feed them directly into the next model. Your AI assistant can use the platform directly, too. Connect Claude Code, Codex, or your own agent with one URL and an API key. We manage the integrations and handoffs. You focus on the science. Understand biology. Predict structures. Design proteins. Discover molecules. One key. One interface. Start building today!

NovaDDE Plus is now live! Built for scientists who use AI for drug discovery every day — more compute, priority access, concurrent runs, API access, and end-to-end campaign execution. $30/month and sign up by September 25 to get your first month free. Our goal is simple: put the most powerful AI for drug discovery into the hands of every scientist. geodesiclab.com/pricing

We’re launching the Geodesic Grand Challenges. What are the hardest questions in drug discovery that, if solved, could change what’s possible over the next 5–10 years? We’re asking you to help define them. Selected questions will become official Geodesic Grand Challenges. Each selected contributor receives 10,000 Geodesic credits. Once the challenges are selected, we’ll open a call for solutions, with a $1 million prize for a verified solution to each challenge. The next breakthrough starts with the right question. Submit yours！ geodesiclab.com/grand-challe…

6/ Today is Day 1 for Geodesic Intelligence. NovaDDE is live. NovaAtom-Lite-Preview is here. Larger NovaAtom models are coming. Our wet lab is scaling. And there is much more ahead. We’re building AI to create medicines, and we’re hiring exceptional people to build it with us. Explore NovaDDE: agent.geodesiclab.com/ Join us: geodesiclab.com/careers

5/ But computation alone isn’t enough. Biology has to work in the real world. That’s why we’re building our own wet-lab capabilities alongside our AI stack, and creating a closed learning loop between AI and the physical world: AI → Design → Experiment → Learn → Repeat. Better models generate better experiments. Better experiments generate better data. Better data builds better models.

4/ And the intelligence behind drug discovery shouldn’t come only from general-purpose AI. Today, we’re also releasing NovaAtom-Lite-Preview, the first model in our NovaAtom family of biological foundation models. NovaAtom-Lite-Preview is our starting point, which is built to move fast, learn fast, and give the community an early look at the NovaAtom architecture and capabilities. Larger and substantially more capable NovaAtom models are already on the way.

3/ Meet NovaDDE — our AI-native, agentic drug discovery framework built for scientists. NovaDDE brings together frontier AI models, domain-specific models, scientific tools, and biological knowledge to reason, search, design, and analyze across complex drug discovery workflows.

2/ Drug discovery is a search and design problem across an enormous biological space. We believe the next generation of AI can fundamentally change that process: reasoning across biology, learning from experimental data, designing new molecules, and helping scientists move from ideas to medicines faster. That’s why we built Geodesic.

1/ Today, we’re introducing Geodesic Intelligence, and launching NovaDDE and NovaAtom-Lite-Preview. Geodesic is building an AI-native platform for protein therapeutics, building AGI for drug discovery to find the shortest path from biology to medicines. geodesiclab.com