We are on a quest to map the human interactome via AP-MS. Check back here for updates on our progress! Steve Gygi, Wade Harper & Ed Huttlin HMS Cell Biology
Boston, MA, USA
Joined October 2019
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HMSBioPlex retweeted
If you're going to #ASMS2025, don't miss these presentations from members of the Gygi lab! You'll learn about TMT, chemoproteomics, GoDig for targeted proteomics, leveraging @HMSBioPlex for drug discovery, new instrumentation, and much more! @edhuttlin @stshuken @AmandaLSmythers
HMSBioPlex retweeted
#ASMS2025 is fast approaching, and I'm looking forward to catching up with friends and seeing a lot of great mass spectrometry research. If you’re there, check out my Tuesday talk (TOE 3:10 PM) to learn how @HMSBioPlex is enhancing drug discovery! @harvardmed @asmsnews
HMSBioPlex retweeted
It’s also worth mentioning that the AP-MS data in this study was collected by the @HMSBioPlex team at @harvardmed.
In a Nature article researchers from HPA and UCLA have used a machine learning approach that enables computational integration of protein localization data from IF images and AP-MS protein interaction data to create a MuSIC map of 5,100 proteins in U2-OS.
proteinatlas.org/news/2025-0…
Protein interaction networks are powerful tools for biological discovery, and they're even better when combined with imaging data. Want to learn more? Check out the latest MuSIC paper! @ProteinAtlas @HMSBioPlex Leah Schaffer @Clarararara_hu @Prof_Lundberg @TreyIdeker @EdHuttlin
🚨 New in Nature @Nature! 🚨
Thrilled to be a co-first author on a global cell map built from U2OS protein imaging + interaction data 🧬🌐
📝 Paper: nature.com/articles/s41586-0…
🗺️ Visualization portal: musicmaps.ai/u2os-cellmap/
HMSBioPlex retweeted
Check out MuSIC 2.0, combining @ProteinAtlas images and @HMSBioPlex interactions to make a multi-scale model of the cell. I enjoyed working on this with @TreyIdeker, @Prof_Lundberg + their labs & collaborators. Special congrats to lead authors Leah Schaffer & @Clarararara_hu!
🚨 New in Nature @Nature! 🚨
Thrilled to be a co-first author on a global cell map built from U2OS protein imaging + interaction data 🧬🌐
📝 Paper: nature.com/articles/s41586-0…
🗺️ Visualization portal: musicmaps.ai/u2os-cellmap/
HMSBioPlex retweeted
🚨 New in Nature @Nature! 🚨
Thrilled to be a co-first author on a global cell map built from U2OS protein imaging + interaction data 🧬🌐
📝 Paper: nature.com/articles/s41586-0…
🗺️ Visualization portal: musicmaps.ai/u2os-cellmap/
It's great to see BioPlex alumnus Jose Navarrete-Perea featured in this month's issue of JASMS! While at Harvard, Jose was a key member of the BioPlex team, keeping our instruments in shape while running thousands of AP-MS samples. @asmsnews @GygiLab pubs.acs.org/doi/10.1021/jas…
HMSBioPlex retweeted
Proteomics Turns 30! It is thirty years since Prof. Marc Wilkins (then an early career researcher) introduced the term "proteomics" at the International Meeting on "2D Electrophoresis: From Protein Maps to Genomes" in Sienna (Italy). #proteomics
It's always gratifying to see how our BioPlex network can help people to advance their research!
Check out this blog post and paper from Alberto Cruz-Martín, @rhushikeshphadk, and colleagues describing how @HMSBioPlex helped them link the complement pathway to synaptic dysregulation!
communities.springernature.c…
rdcu.be/dSTkf
HMSBioPlex retweeted
Today we celebrated the end of an era as @qingyuhms wraps up several highly productive years in the lab! Though we'll miss him, we wish him the best as he starts his own group, and we're glad he'll still be nearby at @UMassChan.
HMSBioPlex retweeted
Join our dynamic team! My lab @UMassChan is seeking postdocs passionate about creating cutting-edge intelligent quantitative (chemo)proteomics platforms. Let's decode protein function and develop novel therapeutics! DM me for a chat and apply at ummsjobs.com/job/10402/
HMSBioPlex retweeted
Good morning! I'm looking forward to presenting our latest @HMSBioPlex work combining PPI mapping with protein structure prediction using AlphaFold. Check it out in session MOH at 10:10 am!
Do you want to hear about the latest developments in the @HMSBioPlex project? Check out @EdHuttlin's #ASMS2024 talk tomorrow: MOH 10:10. See you there!
It's great to have Steve over in Europe sharing our latest work on PPI as well as other recent efforts from the @GygiLab!
And he made such an amazing talk!
Many thanks Steve (@GygiLab) for coming and visiting us. It's been a pleasure to host you in Barcelona! #proteomics #bioplex #AlphaFold
@the_prbb @CRGenomica @UPFbiomed @harvardmed
Check out this talk to learn about recent developments in the @GygiLab, including work we've been doing in @HMSBioPlex!
This Friday we are hosting Steve Gygi (@GygiLab) from @harvardmed at @the_prbb Auditorium in #Barcelona.
What a multiplexed excitement! 🎉
Come and join us.
@UPFbiomed @CRGenomica #proteomics
We are committed to experimental profiling of protein interactions, but computational methods for predicting PPI are an important complement to our work. See this paper from @ernstschmidd and Johannes Walter to learn how they use AlphaFold to predict PPI's at scale! @HMS_BCMP
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HMSBioPlex retweeted
Don't miss this preprint from our colleagues @ernstschmidd and Johannes Walter in @HMS_BCMP. We expect their work with AlphaFold will be an important complement to many of our proteomics projects, from @HMSBioPlex to PTM profiling, chemoproteomics, and more!
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HMSBioPlex retweeted
I'm looking forward to speaking at this @harvardmed Center for Computational Biomedicine meeting on protein structure prediction! I'll be talking about integrating AlphaFold structural predictions with @HMSBioPlex to dramatically improve our understanding of the interactome.
