CV outcomes researcher, Pharmacist, Editor @Circoutcomes, EBM enthusiast, educator. Views are my own.
Joined September 2013
- Tweets1.2K
- Following498
- Followers579
- Likes64K
Cynthia Jackevicius retweeted
When a claim of noninferiority hides factual inferiority!
Data do not support statin discontinuation is safe with respect to MACE.
Presented at #ScientificSessions26:
In older adults with at least two chronic conditions and no known atherosclerotic cardiovascular disease, statin discontinuation was noninferior to continuation for a composite of myocardial infarction, stroke, or death at 2 years. Full STREAM trial results: nej.md/47U1X9N
@AHAScience
ALT A graph from the Original Article "Discontinuing Statins in Older Adults without Cardiovascular Disease." The trial name, STREAM, is in parentheses after the title. The graph shows estimated cumulative incidence of primary-outcome events. The trial results are being presented at the American Heart Association Scientific Sessions 2026. The logo of the New England Journal of Medicine is at the bottom.
Cynthia Jackevicius retweeted
Might be the silliest claim of noninferiority ever
Presented at #ScientificSessions26:
In older adults with at least two chronic conditions and no known atherosclerotic cardiovascular disease, statin discontinuation was noninferior to continuation for a composite of myocardial infarction, stroke, or death at 2 years. Full STREAM trial results: nej.md/47U1X9N
@AHAScience
ALT A graph from the Original Article "Discontinuing Statins in Older Adults without Cardiovascular Disease." The trial name, STREAM, is in parentheses after the title. The graph shows estimated cumulative incidence of primary-outcome events. The trial results are being presented at the American Heart Association Scientific Sessions 2026. The logo of the New England Journal of Medicine is at the bottom.
Cynthia Jackevicius retweeted
Toi on Sunset is a place that, even
by L.A. standards, is truly one-of-a-kind. This is a destination that defined the Sunset Strip for generations; a Thai restaurant with really good food that became an all hours rock’ n roll hangout.
Let’s get into it!
Cynthia Jackevicius retweeted
1/
Rumors of aspirin’s demise are greatly exaggerated.
Concerns with TARGET-FIRST trial:
1. Sample size estimation assumes 1% superiority of P2Y12i monotherapy (2.5% vs 3.5%) rather than conventional equivalence.
2. 80% power low for NI assessment.
nejm.org/doi/full/10.1056/NE…
Cynthia Jackevicius retweeted
Evidentiary landscape for P2Y12i mono-Rx vs DAPT post-ACS is as clear as mud!
Even though non-inferiority was not met technically, P2Y12i mono-Rx was associated with Rx effect ranging from 2% benefit to 68% harm.
Balancing benefit-risk post-PCI is hard.
nej.md/3VeTJT8
Cynthia Jackevicius retweeted
🚨 AI won’t replace doctors… but it can prevent them from learning how to think.
A critical article in @NEJM shows that if introduced too early in medical training, it weakens clinical reasoning.
✅ A good doctor will always need critical thinking.
N Engl J Med 2025;393:786
Cynthia Jackevicius retweeted
AHA/ACC have released the 2025 High Blood Pressure Guideline, emphasizing prevention and early treatment to reduce cardiovascular disease risk.
Read the Guideline in @HyperAHA & @CircAHA and check out our hub with commentaries and more:
ahajrnls.org/4mlSNs4...
Cynthia Jackevicius retweeted
Kudos to @mfiuzat, @batallah08, Robert Page & Orly Vardeny for shedding light on the training, practice, & roles of HF pharmacists. jacc.org/doi/epdf/10.1016/j.…
Cynthia Jackevicius retweeted
This is easily the strongest recent publication supporting #pharmacist co-management of heart failure therapy!
A great salute to the profession of pharmacy!
jacc.org/doi/10.1016/j.jchf.…
Cynthia Jackevicius retweeted
If you take Entresto, we now have the generic and it starts at $33.75 !
It's probably lower than your deductible or Coinsurance. So check it out with your doctor !
📢 Generic Entresto is now available at Cost Plus Drugs ❗️
Sacubitril/Valsartan is now on costplusdrugs.com. A big step forward for those managing chronic heart failure.
Available in:
💊 24mg/26mg 30 tablets - $33.75 - costplusdrugs.com/medication…
💊 49mg/51mg 30 tablets - $33.75 - costplusdrugs.com/medication…
💊 97mg/103mg 30 tablets - $33.75 - costplusdrugs.com/medication…
➡️ No membership fees. No insurance needed. Just transparent pricing! Sign up today at costplusdrugs.com/create-acc…
⭐️ Thank you to Ascend Laboratories for making this possible!
Cynthia Jackevicius retweeted
Both ChatGPT versions demonstrated limited accuracy and reproducibility in answering drug information questions, suggesting that health care professionals should exercise caution when using ChatGPT for drug information. OPEN ACCESS: buff.ly/hAHfRzQ
Cynthia Jackevicius retweeted
Hi, ER Doc here.
Everyone needs to know that taking too much Tylenol can cause liver failure and DEATH. I have seen too many people unintentionally overdose. Do NOT take more than 4 grams in one day. That’s only 8 extra strength pills! Please tell all your friends about this.
Seeking a strong candidate as a Cardiovascular Outcomes Research Fellow! Program designed to develop cardiology pharmacotherapy & research skills for a successful outcomes research/academic career. Sites: WesternU & VA GLA. For more info and how to apply: tiny.cc/02jm001
Cynthia Jackevicius retweeted
Hi, ER Doc here.
I’ve used this account for over 10 years now to teach people about medical emergencies. It’s my birthday today and I’m hoping to hit 700K followers to be able to reach more people.
Can I get some follows and reposts to help me get there?
Cynthia Jackevicius retweeted
Both ChatGPT versions demonstrated limited accuracy and reproducibility in answering drug information questions, suggesting that health care professionals should exercise caution when using ChatGPT for drug information. OPEN ACCESS: buff.ly/hAHfRzQ
Cynthia Jackevicius retweeted
Queen #BUMBLEBEES - HELP THEM OUT!
Another Saturday morning means another vital thread concerning #bumblebee queens at this time of year!
Please #retweet/#share as EVERY QUEEN BEE THAT SURVIVES GETS TO ESTABLISH A NEST that otherwise would not happen. Let me explain.
1/11
#bees
Cynthia Jackevicius retweeted
API-CAP
NI margin of HR of 2! Really!!
Is the 41% loss of efficacy acceptable given no benefit in terms of major bleeding which is a more stringent criterion for clinically relevant bleeding even though the latter was the prespecified bleeding endpoint?
Cynthia Jackevicius retweeted
It’s that time of year - people asking us about #bumblebees - WHY THEY’RE SEEING THEM ON THE GROUND - so here’s a thread to explain what they’re up to.
Please #retweet.
Every #queen that survives means a new colony that gets to exist & produce new queen #bees for next year!
So this is important to share.
Thank you.
1/9
Cynthia Jackevicius retweeted
In anticoagulated patients with atrial fibrillation, bleeding was strongly associated with new cancer diagnoses: an opportunity for cancer diagnosis at an earlier stage @denniskomd @HeartRPh @DouglasLeeMD @dr_mike_fradley @husam247 ahajournals.org/doi/full/10.…
Cynthia Jackevicius retweeted
Instead of listing my publications, as the year draws to an end, I want to put pressure on the commonplace assumption that productivity must always increase. Good research is disruptive and thinking time is central to high quality scholarship and necessary for disruptive research
