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Hedlund Laboratory (@HedlundLab) profile picture

Hedlund Laboratory

@HedlundLab

Using stem cells, tissues and RNA sequencing to understand neurodegenerative diseases @stockholmuniversity and @karolinskainst.

 Stockholm, Sweden
ki.se/en/cmb/hedlund-laboratory
Joined June 2018
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  • Followers483
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Photo by Hedlund Laboratory (@HedlundLab)Photo by Hedlund Laboratory (@HedlundLab)Photo by Hedlund Laboratory (@HedlundLab)Photo by Hedlund Laboratory (@HedlundLab)Photo by Hedlund Laboratory (@HedlundLab)Photo by Hedlund Laboratory (@HedlundLab)Photo by Hedlund Laboratory (@HedlundLab)Photo by Hedlund Laboratory (@HedlundLab)Photo by Hedlund Laboratory (@HedlundLab)
Replying to @HedlundLab
@HedlundLab at @Stockholm_Uni accepted the challenge for the #ALSIceBucketChallenge from @StoppaALS today to raise awareness for this devastating disease. We now in return challenge @RueppLab , @IngreCaroline and @JessicaAlmenas . Please donate to the cause!
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Amazing teamwork with @RueppLab - so grateful for everyone involved on both sides of the pond!
Ruepp Lab (@RueppLab) profile pictureRuepp Lab@RueppLab19 May 2025
Replying to @KingsIoPPN @NatureComms
I am so happy to see this collaboration with @HedlundLab successfully come to fruition. Very grateful for the amazing teamwork and a big thank you to all the members of both our labs who contributed to this study.
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Hedlund Laboratory retweeted
Ruepp Lab (@RueppLab) profile picture
Ruepp Lab@RueppLab19 May 2025
Replying to @KingsIoPPN @NatureComms
I am so happy to see this collaboration with @HedlundLab successfully come to fruition. Very grateful for the amazing teamwork and a big thank you to all the members of both our labs who contributed to this study.
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Check out our manuscript on the transcriptional dynamics in resistant and vulnerable neurons in response to mutant SOD1 and how this was used to predict ALS using machine learning. Thanks to the fantastic students, postdocs & collaborators involved! biorxiv.org/content/10.1101/…
Transcriptional modulation unique to vulnerable motor neurons predict ALS across species and SOD...

Transcriptional modulation unique to vulnerable motor neurons predict ALS across species and SOD...

Amyotrophic lateral sclerosis (ALS) is characterized by the progressive loss of somatic motor neurons (MNs), which innervate skeletal muscles. However, certain MN groups including ocular MNs that...

biorxiv.org
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Hedlund Laboratory retweeted
Diana Piol (@diqnqpi) profile picture
Diana Piol@diqnqpi24 Mar 2023
Our review on the role of TDP-43 and FUS in local translation for the maintenance of axons and neuromuscular junctions in health and ALS is now ONLINE!! authors.elsevier.com/c/1goF2… @TessaRobberech2 & Sandrine Da Cruz
Image from Diana Piol (@diqnqpi)
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Excited to share a preprint biorxiv.org/content/10.1101/… of a collaborative effort with the fantastic teams of @RueppLab and @MartinJastroch focused on understanding motor neuron vulnerability in #ALS across disease causations. Let us know what you think.
Single cell RNA sequencing in isogenic FUS and TARDBP mutant ALS lines reveals early mitochondrial...

Single cell RNA sequencing in isogenic FUS and TARDBP mutant ALS lines reveals early mitochondrial...

Mutations in the RNA/DNA-binding proteins FUS and TDP-43 cause amyotrophic lateral sclerosis (ALS) with distinct neuropathological features. It is currently unclear how these gene mutations lead to...

biorxiv.org
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Hedlund Laboratory retweeted
Marek Bartosovic (@marekbartosovic) profile picture
Marek Bartosovic@marekbartosovic20 Dec 2022
I am really excited 🥳 that this work is now out in @NatureBiotech What used to be sci-fi is now possible! Profile 3 epigenetic modalities with single-cell resolution using sc-nano-CUT&Tag.
Nature Biotechnology (@NatureBiotech) profile pictureNature Biotechnology
@NatureBiotech19 Dec 2022
Multimodal chromatin profiling using nanobody-based single-cell CUT&Tag go.nature.com/3WvhLrO
Image from Nature Biotechnology (@NatureBiotech)
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The Nobel Prize (@NobelPrize) profile picture
The Nobel Prize
@NobelPrize7 Nov 2022
Remembering the first woman to be awarded a Nobel Prize, the first individual to be awarded two Nobel Prizes and still today the only individual with two Nobel Prizes in two different scientific categories: Marie Skłodowska Curie. Curie was born #OnThisDay in 1867.
Image from The Nobel Prize (@NobelPrize)
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The Nobel Prize (@NobelPrize) profile picture
The Nobel Prize
@NobelPrize3 Oct 2022
BREAKING NEWS: The 2022 #NobelPrize in Physiology or Medicine has been awarded to Svante Pääbo “for his discoveries concerning the genomes of extinct hominins and human evolution.”
Image from The Nobel Prize (@NobelPrize)
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The Nobel Prize (@NobelPrize) profile picture
The Nobel Prize
@NobelPrize3 Oct 2022
Someone is receiving exciting news from Thomas Perlmann, the Secretary of the medicine committee. Find out who will receive this year’s #NobelPrize in Physiology or Medicine – we’re just moments away from breaking the news. Photo: Yanan Li.
Thomas Perlmann, the Secretary of the medicine committee is sitting in an office where he is on the phone. He is giving the news to the newest Nobel Prize laureate in Physiology or Medicine.

ALT Thomas Perlmann, the Secretary of the medicine committee is sitting in an office where he is on the phone. He is giving the news to the newest Nobel Prize laureate in Physiology or Medicine.

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If you are interested in neuronal vulnerability in @ALS please check out our new review in @Biology_MDPI mdpi.com/2079-7737/11/8/1191
The Cell Autonomous and Non-Cell Autonomous Aspects of Neuronal Vulnerability and Resilience in...

The Cell Autonomous and Non-Cell Autonomous Aspects of Neuronal Vulnerability and Resilience in...

Amyotrophic lateral sclerosis (ALS) is defined by the loss of upper motor neurons (MNs) that project from the cerebral cortex to the brain stem and spinal cord and of lower MNs in the brain stem and...

mdpi.com
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Hedlund Laboratory retweeted
Biology MDPI (@Biology_MDPI) profile picture
Biology MDPI@Biology_MDPI8 Aug 2022
The Cell Autonomous and Non-Cell Autonomous Aspects of Neuronal Vulnerability and Resilience in Amyotrophic Lateral Sclerosis mdpi.com/1766094 #mdpibiology via @Biology_MDPI @Stockholm_Uni amyotrophic lateral #sclerosis; #neurodegeneration; #neuron
The Cell Autonomous and Non-Cell Autonomous Aspects of Neuronal Vulnerability and Resilience in...

The Cell Autonomous and Non-Cell Autonomous Aspects of Neuronal Vulnerability and Resilience in...

Amyotrophic lateral sclerosis (ALS) is defined by the loss of upper motor neurons (MNs) that project from the cerebral cortex to the brain stem and spinal cord and of lower MNs in the brain stem and...

mdpi.com
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We are looking for new postdocs to join our lab at Stockholm University: dbb.su.se/about-us/vacancies… dbb.su.se/about-us/vacancies…
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Eva Hedlund and her research team aim to find new treatments for patients with diseases such as ALS and SMA by seeking to identify and transfer the properties of resistant nerve cells. @HedlundLab

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Hedlund Laboratory retweeted
Jorge Lira Ruas (@ruaslab) profile picture
Jorge Lira Ruas@ruaslab29 Sep 2021
Latest from our lab!! Very happy about the outcome.
Cell Metabolism (@Cell_Metabolism) profile pictureCell Metabolism@Cell_Metabolism29 Sep 2021
Muscle-secreted neurturin couples myofiber oxidative metabolism and slow motor neuron identity dlvr.it/S8b62g
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Hedlund Laboratory retweeted
Ruepp Lab (@RueppLab) profile picture
Ruepp Lab@RueppLab29 Jul 2021
We were challenged by the @HedlundLab and responded with #Icefoot92 in support of the @LJohnrose project 92 for the @mndassoc. More information is available at mndassociation.org/icefoot92. We now challenge the @SMizielinska and @MitchellLab3 labs.
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Our paper on spatial RNAseq of human VTA and SNc dopamine neurons to understand neuronal resilience and vulnerability in #ParkinsonsDisease using LCM-seq is finally out: frontiersin.org/articles/10.…. Thanks to all amazing coauthors, collaborators @QiaolinDeng and @Parkinsonfonden
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Hedlund Laboratory retweeted
StoppaALS (@StoppaALS) profile picture
StoppaALS@StoppaALS19 Jun 2021
Nu var det min och barnens tur att göra #ALSIceBucketChallenge. Vi utmanar: @HedlundLab, @KP_twitt_llo & @KmanSweden Den som vill får gärna skänka en slant till Stoppa ALS insamling: egnainsamlingar.neuro.se/fun…. Eller swisha till 9010075 med meddelande "Ice Bucket". #stoppaals
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Looking forward to the virtual 3-day ALS webinar which starts today at 11 (BST) ⏰ 🗣️Fantastic speakers lined up to discuss 'Mechanistic insights into the pathophysiology of ALS' 👉ukdri.ac.uk/events/als-2021
Image from UK Dementia Research Institute (@UKDRI)
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