@HowittLab

We study the microbiome and its effect on intestinal immunity

 Stanford University
howittlab.com
Joined March 2020
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Howitt Lab retweeted
Long Lab@longlabstanfordOct 22
Our work deorphanizing MCT6 as the missing gut Lac-Phe transporter is out today @CellCellPress: local gut lactate metabolism influences gut-brain crosstalk, and also explains metformin’s effects on body weight. Congratulations to @Shuke_Xiao @alanshtung! cell.com/cell/fulltext/S0092…

MCT6 is an intestinal Lac-Phe exporter required for metformin-associated weight loss

The orphan transporter MCT6 is the route by which the meal- and exercise-associated metabolite Lac-Phe exits intestinal cells and enters the blood. Mice lacking gut MCT6 cannot maintain normal...

cell.com
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Excited to share our work in Science Immunology! Tuft cell signaling remodels the follicle-associated epithelium, influences M cell maturation, and promotes antigen-specific IgA responses. Led by @gabebarron. Thanks @DrRosenIBD & @jakob_moltke! science.org/doi/10.1126/scii…

Follicle-associated epithelial tuft cells amplify type 2 mucosal immunity and IgA production

Two intestinal cell types share developmental traits and combine microbial sensing with antigen delivery to shape antibody responses.

science.org
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