Ph.D Cellular and Molecular Biology UC. MSc. in Neurosciences (UValparaiso) Postdoc Research UMayor #CellularBiology #cellsignaling #ER #ER-Phagy
Santiago, Chile
Joined January 2011
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Hugo Almarza Salazar retweeted
New Viewpoint: Yannick Frey and Hesso Farhan @Hesso_F_Sci discuss why competing ER export models persist and argue that vesicles, tubules, and tunnels are alternative outputs of a flexible ER export machinery. hubs.la/Q04CCrP90
Hugo Almarza Salazar retweeted
Viewpoint: Zhiqi Tian, Yujie Sun, and Jiajie Diao discuss how #mitochondria supply protons to acidify #lysosomes through direct membrane contacts, and consider implications for mitochondrial quality control, aging, and disease therapeutics. hubs.la/Q04CtvYy0
#Biophysics
Hugo Almarza Salazar retweeted
Chronic progressive demyelination induces a microglial state with lysosomal dysfunction @NatureNeuro
nature.com/articles/s41593-0…
Hugo Almarza Salazar retweeted
<fc>TMEM55B</fc> Maintains Lysosomal Homeostasis and Promotes <fc>ER</fc>–Lysosome Calcium Signaling - Mukae - 2026 - Traffic - Wiley Online Library onlinelibrary.wiley.com/doi/…
Hugo Almarza Salazar retweeted
In this Cell Science at a Glance article and poster, Eric Chevet, Elodie Lafont & team look at how the ER adapts to stress through various mechanisms, ranging from activation of signalling cascades to physical association with other organelles.
journals.biologists.com/jcs/…
ALT JCS poster: Responses to endoplasmic reticulum stress at a glance Eric Chevet, Céline Philippe, Tony Avril, Elodie Lafont
Hugo Almarza Salazar retweeted
Tau hyperphosphorylation impairs cooperative binding to microtubules and perturbs organelle trafficking in neurons
elifesciences.org/articles/1…
Hugo Almarza Salazar retweeted
ほんまか（今まで誰もしとらんかったんか？）と思う実験。アルツハイマー病などに罹患した患者の脳からタウ線維を抽出、マウス脳に移植することでマウスのタウタンパク質も同様に集合することを示した論文。Nature。
nature.com/articles/s41586-0…
Hugo Almarza Salazar retweeted
Glycosylation is among the most important modifications in biology.
We know relatively little about glycobiology, because it is hard to study.
This Nat Rev Methods primer describes our best tools for analyzing glycosylation 🔽
Hugo Almarza Salazar retweeted
Mitochondria-ER-lipid droplet crosstalk regulates metabolic adaptation to shear stress via VMP1: Current Biology cell.com/current-biology/ful…
Hugo Almarza Salazar retweeted
Clathrin-coated tubules mediate rapid and selective protein absorption by lysosome-rich enterocytes biorxiv.org/content/10.64898…
Hugo Almarza Salazar retweeted
Structure and function of the DFCP1 membrane barrier responsible for ER microdomain organization in lysosome repair biorxiv.org/content/10.64898…
Hugo Almarza Salazar retweeted
Nature research paper: GRP75-dependent SIMPA mediates inter-organellar quality control
go.nature.com/4zQqXux
Hugo Almarza Salazar retweeted
The AP-1 clathrin adaptor has a conserved role in recycling resident proteins of the trans-Golgi network biorxiv.org/content/10.64898…
Hugo Almarza Salazar retweeted
RanGAP1 coordinates the ER-lamina interface to drive de novo nuclear envelope reassembly in mouse embryos | Science Advances science.org/doi/10.1126/scia…
Hugo Almarza Salazar retweeted
BAK and BAX form a multiprotein complex to drive mtDNA efflux and caspase-independent cell death | Science science.org/doi/10.1126/scie…
Hugo Almarza Salazar retweeted
Mitochondrial subpopulations promote cellular responses to changes in metabolic demand and signal transduction | PNAS pnas.org/doi/10.1073/pnas.26…
Hugo Almarza Salazar retweeted
Just Published ! #TrafficLights commentary onlinelibrary.wiley.com/doi/…
Hugo Almarza Salazar retweeted
The N-Ank protein Ankrd24 shapes neurons and couples to syndapin and the F-actin promoter Cobl-like rupress.org/jcb/article/225/…
Hugo Almarza Salazar retweeted
A team at the University of Basel has identified a molecular switch that controls how cells ensure that the right cargo ends up in the right recycling vesicle. hubs.la/Q04BCR620
See the original article from @Spang_Lab @biozentrum @UniBasel_en hubs.la/Q04BCRdk0
Hugo Almarza Salazar retweeted
Spotlight: Clegg, Ferguson et al. (hubs.la/Q04BPJn20) show that PIKfyve inhibition swells #lysosomes, traps Rab #GTPases, and activates #LRRK2 without the GABARAP–CASM pathway. @pfeffersuzanne @StanfordMed discusses the findings: hubs.la/Q04BPHD80