Respiratory 🫁 doctor. Specialist interest in asthma
London, England
Joined January 2013
- Tweets6.6K
- Following513
- Followers1.8K
- Likes10K
Hugo Farne 🫁 retweeted
Great work from @alferes_de and @lifearc1 - a molecular test for Pseudomonas which is more sensitive than culture, quantitative and changes over time with treatment/clinical status.
We are working now on using this as an endpoint in clinical trials. More to come!
A novel bacterial quantification assay (BQA) targeting ribosomal RNA for the detection of viable P. aeruginosa from clinical samples in bronchiectasis has been developed. The BQA shows promise as an early detection diagnostic and treatment monitoring tool. bit.ly/4rf7rnr
Hugo Farne 🫁 retweeted
Further evidence of the challenges in targeting the mighty neutrophil.
Our trial of Myeloperoxidase (MPO) inhibition in COPD found no efficacy, and increased pneumonia
Just published in @ERSpublications
publications.ersnet.org/cont…
Hugo Farne 🫁 retweeted
New research confirms what we've suspected for a long time - the "test dose" of hypertonic saline in clinic does nothing except test the variability of spirometry as a measure
Most people who failed the test passed a repeat. Most people who couldn't tolerate HTS long term passed the test first time
thorax.bmj.com/content/early…
Hugo Farne 🫁 retweeted
I’m not a BMA member, but this statement is one I support: Reducing funding for clinical academics when numbers are already in decline fails to recognise their contribution to the health & wealth of the UK.
The financial saving is minimal but I fear the costs will be substantial
Responding to @officestudents guidance from the Secretary of State for Education setting out funding for 2026-27 for universities that imposes cuts to funding for medical academics: bma.org.uk/bma-media-centre/…
Hugo Farne 🫁 retweeted
Responding to @officestudents guidance from the Secretary of State for Education setting out funding for 2026-27 for universities that imposes cuts to funding for medical academics: bma.org.uk/bma-media-centre/…
Hugo Farne 🫁 retweeted
This study validates a previously reported bronchial signature of bronchiectasis in nasal epithelium. Changes in gene expression and cell-type composition associated with radiological bronchiectasis are similar across both bronchial and nasal epithelia. bit.ly/4qgq7SO
Hugo Farne 🫁 retweeted
European Respiratory Journal: TSC2 mutations are the main cause of sporadic LAM in nearly all patients bit.ly/4rZoqtJ
Hugo Farne 🫁 retweeted
Inhaled anti-TSLP for persistent asthma -Phase 1 study
linkinghub.elsevier.com/retr…
AZD8630 well tolerated with low incidence of ADA
Suppression of FeNO indicating effects on airway epithelial cells and downstream IL13 signalling
Hugo Farne 🫁 retweeted
Excited to share our ‘Evolutionary characterization of #LungCancer metastasis’ in #TRACERx & #PEACE, published today in @Nature: a decade spanning effort led by the Jamal-Hanjani lab, @SwantonLab, @NickyMcGranahan & @ZaccaSimo at @uclcancer & @TheCrick. Link below
Hugo Farne 🫁 retweeted
A study 10 years in the making, just published in @LancetRespirMed
How do DPP1 inhibitors really work in bronchiectasis?
We show a novel mechanism for treatment efficacy, by inhibiting Azurocidin-1, a ciliotoxin, DPP1i can enhance mucociliary clearance.
thelancet.com/journals/lanre…
Hugo Farne 🫁 retweeted
ECCMID 2026
No induction of resistance over 6 months with monoclonal antibody therapy against pseudomonas in bronchiectasis
Encouraging beneficial changes to the microbiome too
Encouraging early results presented by @beccahull_
Hugo Farne 🫁 retweeted
People often ask how breakthroughs occur in cancer biology-often the story is more complex - the survival plot for myeloma outcomes is extraordinary - improvements come about in incremental steps - in my lifetime treatment of Myeloma has almost transformed into a curable disease
Hugo Farne 🫁 retweeted
No cigar for Rilzabrutinib (BTK inhibitor) in mod-sev asthma (Ph 2)
Futility on primary EP of loss of asthma control upon withdawal of ICS/LABA
thelancet.com/journals/lanre…
Hugo Farne 🫁 retweeted
“A stark and avoidable injustice in respiratory health” ⚖️
This, in the words of @HugoResp, is the situation laid bare by a recent analysis of NHS admissions data by @asthmalunguk 🫁
Dr Farne was interviewed as part of @guardian coverage of the study: theguardian.com/society/2025…
Hugo Farne 🫁 retweeted
We have a one year clinical fellow post (maternity cover) available. Study looking at human viral challenge in bronchiectasis. Would suit IMT or specialist respiratory trainee. Details: imperial.ac.uk/jobs/search-j… Grateful for retweets. Please DM/email if interested.
Hugo Farne 🫁 retweeted
Restricting access to suicide methods is one of the best evidenced approaches to prevention.
Barriers on bridges, limits on paracetamol & in developing countries, a ban on pesticides.
New review by my Manchester colleagues & friends. 1st author @SarahESteeg
📢 New Research 👇🏼
Does restricting access to lethal means prevent suicide?
An umbrella review in @BMJMentalHealth finds strong evidence for physical barriers, pesticide bans & reduced paracetamol pack sizes, though study quality varies & LMIC data are scarce.
Read more 👇🏼 mentalhealth.bmj.com/content…
#SuicidePrevention #PublicHealth #MentalHealth #MeansRestriction
Hugo Farne 🫁 retweeted
Really coool. And very relevant to Pulmonary Fibrosis
#ScienceMatters
#CurePF4All
science.org/doi/10.1126/scie…
H/T @HaoYin20
Hugo Farne 🫁 retweeted
Closing the Early Career Symposium, impressive work from Rebecca Hull @beccahull_ @dundeeuni showing positive results from the GREAT2 trial of anti-P.aeruginosa mAb in bronchiectasis, no resistance development, and improved microbiome #BTSWinter2025 @BTSrespiratory @asthmalunguk
