Providing training in Flow Cytometry for thousands of researchers since 2011. Immunologist and Flow Cytometrist for 25 years. ImmunologyExplained Patreon

Wensleydale, UK
Joined November 2011
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Replying to @NickAnderegg
That is irrelevant to your claim that it impacts immunity against other pathogens
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Replying to @NickAnderegg
I decided to correct your incorrect statement
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Replying to @NickAnderegg
I pointed out a clarification to your post, so yes, I am helping. I have not said that there is no impact on immunity. ALL viruses have some form of immune evasion or suppression. Do you think you are helping by misleading people?
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And that is important when your posts are read by non-scientists. If they interpret your posts as meaning that the SC2 virus can damage immunity against other pathogens, then you are misleading them.
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Replying to @NickAnderegg
I would agree that the virus can exhaust T cells against that infection specifically, yes.
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Replying to @NickAnderegg
I spend most of my time dealing with antivaxers, virus deniers, conspiracy theorists and cranks. You are none of those. However, scientific accuracy is absolutely vital, and there is a common claim that the virus causes general immune damage. It doesn't
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InCytometry - Graham Bottley retweeted
I did wonder if using a picture of a bacteriophage would upset some virus deniers & (rolls eyes) yes it did… A virus which infects bacteria is a virus—I also love their utterly funky appearance! Here’s a picture of a difference virus, one which affects mammals, can you name it?
Yeah—it’s worth saying this very clearly: Viruses exist We have abundant proof of their existence If you don’t understand that proof, this looks to be willful ignorance and very much a you problem Viruses are very much a real thing Image shows structural model
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But potentially yes, very much so.
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Replying to @NickAnderegg
That depends on the time between infections, the severity of infection, the infectious dose the second time and whether there was viral persistence, which in itself is a major cause of T cell exhaustion
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Replying to @NickAnderegg
You said that it increased susceptibility to other infections and cancer. So yes, you did.
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Replying to @NickAnderegg
Other pathologies. So other symptoms of the infection. Yes. Exactly.
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See what you are doing is reading a paper without understanding the methodology or the immunological context, and then you are extrapolating that to a downstream effect that doesn't occur.
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Replying to @NickAnderegg
Oh my word. Right. There IS T cell exhaustion, but only in some clonal lineages. Not in all T cells. That is a very, very important distinction. And the papers you yourself link to show that. Have you not even read them?
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Replying to @NickAnderegg
No. You clearly don't understand the literature. No literature anywhere shows general T cell exhaustion.
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Explain then how HLA-restriction maps geographically to viral epitopes then.
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They are jealous. I have three successful businesses that make a real difference to people in one way or another. Maybe because they have never achieved anything, they feel the need to criticise.
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Amazing, isn't it. I have made over half a million £ from that hobby so far, doing something I really enjoy, and with a worldwide appreciative audience. They somehow see it as a negative thing. Says a huge amount about their own outlook on life.
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Back from Cyto 24 now Very tiring, but what a fantastic conference all round!
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