Research lab interested in how the developing brain comes online | circuits | GABAergic interneurons | in vivo ephys & imaging 🧠🧪. 💙neuroskyence now 🦋.
Oxford, England
Joined January 2017
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Butt Lab - Oxford retweeted
1/ Early-life stress changes how we handle later threat.
However, most research averages across animals and tracks a few readouts, so individual stories get lost.
We changed that with ML-driven computational ethology to map coping one mouse at a time.
New #bioRxiv preprint 👇
biorxiv.org/content/10.1101/…
A rather 'unique' paper from our lab is online in @CellReports now. Unique in the sense that I don't think anyone else will be rushing to optotag cortical interneurons in the early postnatal brain... because it is nigh on impossible!
doi.org/10.1016/j.celrep.202…
Great credit must go to the team @GhezziFilippo, @IntoNeurons, and the rest of the gang for persevering and demonstrating that (mainly SST) interneurons contribute to the formative activity that sculpts and creates the circuits that underpin our conscious thoughts.
Butt Lab - Oxford retweeted
What does the claustrum actually do?
This study explores how this mysterious brain region processes sensory signals and connects across the cortex. While the evidence for its role is still incomplete, the data offer a useful foundation for future work.
elifesciences.org/articles/9…
Butt Lab - Oxford retweeted
Happy to share this new paper from the lab in collaboration with George Augustine, characterizing synaptic connectivity between the claustrum and the anterior cingulate cortex. Congratulations to Roberto, Zach, and all co-authors! @RobertodelaTor
New in Current Biology
"Presynaptic and postsynaptic determinants of claustro-cortical connectivity"
CLA→ACC projections are highly specific: defined by presynaptic identity, postsynaptic target, and cortical layer.
Check it here: sciencedirect.com/science/ar…
#Neuroscience #Claustrum
Our study on the impact of altered serotonin (5-HT) signalling on developing sensory cortex is now live @NatureComms
We use longitudinal in vivo imaging of 5-HT & neural activity to show that this neuromodulator is buffered in early life to promote bottom-up instruction.
Increasing 5-HT through genetic, pharmacological (SSRIs) or adverse stimuli results in an altered trajectory for the development of GABAergic interneurons, impacting early activity and – in the case of SSRIs – that present through to adulthood:
rdcu.be/epHXV
Many thanks to all the team & our collaborators but especially @OcanaSantero for his amazing in vivo imaging & @WarmingHannah for her top patching skills. Significant contributions from @paqio and @yulonglilab. The work was funded by grants from @UKRI_News & @ERC_Research
Butt Lab - Oxford retweeted
How do cognitive maps fail? And how can this help us understand/treat psychosis? My lab at Experimental Psychology, Oxford is hiring a Postdoc tinyurl.com/2p935hhz and RA tinyurl.com/3myfpb78 to answer these questions in mouse models.
Here's why you might want to join: 🧵
Butt Lab - Oxford retweeted
1/ 🚨 Excited to share our latest study: Perinatal serotonin signalling dynamically influences the development of cortical GABAergic circuits with consequences for lifelong sensory encoding🧠 Here’s what we found:
Butt Lab - Oxford retweeted
Funded PhD opportunity at @UoBrisPPN for UK applicants of Black African or other Black or mixed Black heritage - collaborative project with @P_Anastasiades & @clembrnrd & me on the neural and molecular underpinnings of negative symptoms in schizophrenia FindAPhD.com
Butt Lab - Oxford retweeted
Boom! New from The Goldberg and Plotkin labs: Cholinergic interneurons facilitate serotonin release in the striatum. @GoldbergLab @lab_plotkin
biorxiv.org/content/10.1101/…
Butt Lab - Oxford retweeted
Developmental Common Coordinate Framework (DevCCF) for developing mouse brain atlases is out. nature.com/articles/s41467-0… It features MRI and light-sheet co-registered templates and 3D anatomical labels based on developmental ontology from embryonic to adult ages
Butt Lab - Oxford retweeted
Exciting #PhD opportunity @TheCrick @dev_neuro @KingsIoPPN to study the control of mitochondrial activity during brain development & disorders jointly supervised by @NeuroMikeD & myself @HouartLab . Interested? Apply for Crick-KCL PhD programme 2025!
crick.ac.uk/careers-study/va…
Butt Lab - Oxford retweeted
Check out our poster A67 on cortical somatostatin interneurons of postnatal mice, from molecular to systems level, at #SfN24 tomorrow morning. This work is from the @Interneuron_Dev lab together with @ENtaouka, @antpcolorado, and Lynn Geyer in collaboration with @HjerlingLeffler.
Butt Lab - Oxford retweeted
If you are at #sfn2024, come check poster M17 this afternoon to see how we used gated deep neural networks and all-optical experiments during learning to unveil a new role of cortical serotonin. A collaboration between @SaxeLab @stefsmlab @Interneuron_Dev @paqio and Trevor Sharp
Butt Lab - Oxford retweeted
Why are some neurons more selective than others? We report now in @Nature how calcium permeable-AMPA receptors in PV neurons make them less selective to sensory features nature.com/articles/s41586-0… Long live the geniuses behind this🧠🔍juhyun.kim @thainmueller @rhuganir
Butt Lab - Oxford retweeted
And we are off for this year’s edition of Developing Brains! @UlrikaKMarklund delivering the opening address. A full day off amazing science from @Interneuron_Dev, @HanganuOpatzLab, @ErinMGibson, @TSS_Lab, @MartinUCSF @RuizdeAlmodovar, @acestreit, @Franze_Lab
Butt Lab - Oxford retweeted
Fully @The_MRC funded #PhD studentships @KCL_MRCDTP now open! Project with me @dev_neuro and Sam Cooke @WolfsonSPaRC both @KingsCollegeLon on the functional development of circuits for learning and memory (kcl-mrcdtp.com) NS-MH2025_07 #MRCDTP25
Applications for @KingsCollegeLon @The_MRC Doctoral Training Partnership in Biomedical Sciences 2025 entry are now OPEN!
Visit our website kcl-mrcdtp.com for more information.
#MRCDTP2025
