@JExpMed
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The Journal of Experimental Medicine publishes immunology, cancer, stem cells, microbial pathogenesis, vascular biology, neurobiology. Est. 1896 - @RockUPress
New York, NY
Joined September 2009
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Scientists co-led by @StJudeResearch have identified a potential therapeutic vulnerability in some forms of #osteosarcoma.: hubs.la/Q04C482h0
See the original study by @JunQiLab @ADurbinLab and colleagues here: hubs.la/Q04C482j0
Tumor-reactive LAG3⁺CD8⁺ T cells diverge into terminally exhausted cells and long-lived memory #Tcells. From Vaishali Aggarwal, Yangxi Sun, Chang Liu, Dario Vignali @Vignali_Lab: hubs.la/Q04BVX1g0
Part of our Immune #Tolerance collection 👉 hubs.la/Q04BVWH10
Stevenson et al. (hubs.la/Q04C2t0l0) highlight the functional consequence of α-syn aggregates at the brain border, uncovering their active role in reshaping lymphatic integrity and the neuroimmune macroenvironment. Insights from the Tischfield lab: hubs.la/Q04C2s_s0
Zhang et al. show that Ag-independent IgM BCR signaling restrains human IgM PC differentiation & persistence. Disruption of SYK enhances IgM PC output & persistence, which can be leveraged to improve the durability of engineered IgM-secreting PCs. hubs.la/Q04C2sp20
Helios is critical for Treg effector differentiation in #adipose #autoimmunity. From Angela M. Thornton, Ethan M. Shevach and colleagues hubs.la/Q04BVWBF0
Part of our Immune #Tolerance collection 👉 hubs.la/Q04BVWBH0
Explore new collection accompanying @CSHANews meeting. The studies reveal mechanisms that shape immune responses to self, commensal, environmental, & tumor antigens & identify new strategies for promoting immune #tolerance or enhancing antitumor immunity: hubs.la/Q04BVHYP0
Researchers @UOsaka_en uncover early changes seen in ANCA-associated glomerulonephritis and investigate a treatment to stop it in its tracks: hubs.la/Q04B_R930
See the original study here: hubs.la/Q04B_QYr0
Journal of Experimental Medicine retweeted
Online today in @JExpMed,
doi.org/10.1084/jem.20251898
TLDR: a genetically-defined group of osteosarcoma is sensitive to the EP300 PROTAC JQAD1, due to a balance between degradation and resynthesis by the ribosome. Read on for deets...
Journal of Experimental Medicine retweeted
New research published in @JExpMed from @DanaFarber’s @JunQiLab and collaborators reveals that AKT inhibitors synergize with EP300 degraders to suppress osteosarcoma growth in vitro and in vivo. These agents positively combine across cancer cells in a manner dependent on control of protein synthesis.
➡️bit.ly/4z13y9G
Spinella, Natoli, Monticelli et al linked a #Crohns disease risk allele regulating SKAP2 expression to #Tcell function. SKAP2 enhances cell adhesion while suppressing migration. Sustained TCR signaling triggers its proteolytic cleavage to enable migration. hubs.la/Q04BPBxt0
Journal of Experimental Medicine retweeted
1/ We are excited to share our new paper in @JExpMed!
doi.org/10.1084/jem.20251245
Here we show that α-synuclein, a protein involved in Parkinson’s disease, triggers inflammation at CNS borders and impairs CNS clearance.
Journal of Experimental Medicine retweeted
Excited to share our work in @JExpMed led by @t_stevenson95. We show that aggregated α-synuclein at CNS borders drives inflammation and impairs lymphatic function, positioning meningeal immunity as a driver of clearance deficits in Parkinsons disease.
tinyurl.com/5yvpsxhm
Journal of Experimental Medicine retweeted
So exciting to have this paper online @JExpMed . thanks for the wonderful collaboration with @ADurbinLab @TheAbraLab, Ory lab. Congratulations on all the team members.
The first authors are: Ian M. Delahunty, Stephanie Nance, Yang Zhang, François Lamoureux, and Qi Liu.
From Ory lab @NantesUniv, @JunQiLab @DanaFarber, @TheAbraLab, and @ADurbinLab @MolOnc_StJude @StJudeResearch @StJudegraduate
Delahunty et al. identify that EP300 controls the growth of AKT-dysregulated #osteosarcoma cells by regulating expression of state-specific genetic dependencies. AKT inhibitors synergize w/ EP300 degraders to suppress osteosarcoma growth in vitro & in vivo hubs.la/Q04BMjg50
The first authors are: Ian M. Delahunty, Stephanie Nance, Yang Zhang, François Lamoureux, and Qi Liu.
From Ory lab @NantesUniv, @JunQiLab @DanaFarber, @TheAbraLab, and @ADurbinLab @MolOnc_StJude @StJudeResearch @StJudegraduate
.@t_stevenson95, @JSRustenhoven et al. @FMHS_UoA show that aggregated α-synuclein at CNS borders drives inflammation and impairs lymphatic function, positioning meningeal immunity as a driver of clearance deficits in #Parkinsons disease. hubs.la/Q04BMF_S0
#Neuroinflammation
Adenosine metabolic clearance maintains liver homeostasis by licensing arginine methylation of RIPK1, from Ran Liu, Gengqiao Wang, Zhengting Jiang, Jinyang Gu and colleagues: hubs.la/Q04B0P600
📘 From our #Cytokines collection: hubs.la/Q04B0P6t0
#Cytokines2026
Herpesvirus CNS infections in genetically heterozygous - transcriptionally homozygous IRF7 deficiency. From Marvin Werner, Trine Mogensen and colleagues: hubs.la/Q04B0P3Y0
📘 From our #Cytokines collection: hubs.la/Q04B0NQr0
#Cytokines2026
Insights: New study from @MNishide1120 et al. (hubs.la/Q04BB2bH0) identified activated #neutrophils in kidneys in anti-MPO–associated #vasculitis. Anne Davidson @NorthwellHealth highlights the findings: hubs.la/Q04BB2QH0
#inflammation #Autoimmunity
.@MNishide1120, Kumanogoh et al. @UOsaka_en identify #neutrophil-epithelial niches linking epitope-diverse anti-MPO #autoantibodies to kidney injury in ANCA-associated #glomerulonephritis, with protection by engineered one-armed antibodies. hubs.la/Q04BB02x0
#Autoimmunity
